StromallyExpressedc-JunRegulatesProliferationofProstateEpithelialCells
...ptionfactormoleculeshavebeenshowntoregulatestromal-epithelialinteractionsviaparacrinesignals.Moreover,theJun-familymemberproteinshavebeenshowntoplayanimportantroleinproperdevelopmentofthegenitourinaryorgans.Inthisstudy,weshowthatc-Junproteininfibroblastsregulatesproductionandparacrinesignalsofinsuli...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第10期MelagatranReducesAdvancedAtheroscleroticLesionSizeandMayPromotePlaqueStabilityinApolipoproteinE-DeficientMice
...hodsandResults-Melagatran(500µmol/kg/d)orcontroldietwasadministeredtoapolipoproteinE-deficientmice(n=54)withadvancedatheroscleroticlesions.Treatmentreducedlesionprogressioninbrachiocephalicarteries(P0.005).Morphometricanalysisconfirmedthatthrombininhibitionpromotedplaquestabilityandresultedint...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第12期MolecularmechanismsofenhancedrenalcelldivisioninprotectionagainstS-1,2-dichlorovinyl-L-cysteine-inducedacuterenalfailureanddeath
....However,cyclinD1expressionwashighprobablyduetotranscriptionalcooperationofAP-1.CyclinD1/cyclin-dependentkinase4(cdk4)-cdk6system-mediatedphosphorylationofretinoblastomaproteinwasdownregulatedduetooverexpressionofp16at24hafterexposuretothelethaldosealone.InhibitionofS-phasestimulationwasconfirmedbyp...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第7期TonicallyActiveGABAAReceptorsinHippocampalPyramidalNeuronsExhibitConstitutiveGABA-IndependentGating
...r,gabazine,ataconcentrationthatabolishedminiatureGABAergicinhibitorypostsynapticcurrentsandresponsestoexogenousGABA,hadnoeffectontoniccurrents.BecauseallGABA-activatedGABAAreceptorsinpyramidalneuronsaregabazine-sensitive,itfollowsthattoniccurrentsarenotGABA-activated.Furthermore,picrotoxin-sensitive...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第2期缺血/再灌注腦損傷與蛋白質合成抑制
...,這兩種基因的表達產物FOS和JUN結合形成活蛋白-1複合物(AP-1),它通過與靶基因上相應的AP-1位點的特異性結合激活這些基因的轉錄,從而直接影響蛋白質合成,這一機制在細胞分化和增生及細胞膜損傷修復中起重要作用[5]。...
合作平臺;醫學論文;基礎醫學論文;神經生物學Race-ethnicityspecificwaistcircumferencecutoffsforidentifyingcardiovasculardiseaseriskfactors
...Nutrition,CollegeofPhysiciansandSurgeons,ColumbiaUniversity,NewYork(SBH,ZW,AP,andSH);theDepartmentofPublicHealth,NagoyaUniversityGraduateSchoolofMedicine,Nagoya,Japan(HT);andthePediatricUnit,VeronaUniversityMedicalSchool,Verona,Italy(AP)2SupportedbyagrantfromPfizerPharmaceuticalIncandNationalInstitu...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年81卷第2期錳暴露與心血管功能
...平高濃度錳(Mn2+1~8mmol/L)可使豚鼠心肌細胞動作電位(AP)復極50%及90%時程,有效不應期(APD50,APD90,EPR)縮短,AP零相最大上升速率(Vmax)減小。高濃度Mn2+對心肌收縮力的抑制作用較強,低濃度時Mn2+(0.5mmol/L)能明顯抑制...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2006年第6卷第8期蛋白芯片的基本原理及技術研究現狀
...G按每點爲1納升的點樣量點樣10799次,另一次用FRB(FK-BR12-rapamycinbindingdomainofFKBP-rapamycin-associatedprotein)點樣。爲了確保不同分子量的點樣蛋白質都能夠被固定在玻片上,他們首先在玻片表面塗上BSA,然後使用N,N’-二琥珀酰胺碳酸(N,N...
醫藥經濟;生物技術;實驗技術;生化與分子技術粘附分子E-selectin在急性胰腺炎大鼠肺組織中的表達
...iabang,LiFei,etal. DepartmentofGeneralSurgery,XuanwuHospital,CapitalUniversityofMedicalSciences,Beijing100053. 【Abstract】ObjectiveToexploretheroleofE-selectininpathogenesisofacutepancreatitisassociateda-cutelunginjury(PALI)inrats.MethodsPancreatitiswasinducedwith3.5%sodiu...
合作平臺;在線期刊;中華醫學研究雜誌;2005年第5卷第4期;論著豬卵透明帶-3α蛋白在大腸桿菌中表達的研究
...序。在擴增的該基因5‘端小片段與雙酶切3‘端大片段在ApaI位點相連後,通過雙酶切位點將讀框完整的目的基因定向插入pBV221表達質粒PRPL啓動子下游的多克隆區。結果:此重組表達質粒轉化宿主菌後經熱誘導培養,可在SDS-PAGE膠...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學