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ReductionofAtheroscleroticPlaquesbyLysosomalAcidLipaseSupplementation
...354.LougheedM,LumCM,LingW,SuzukiH,KodamaT,SteinbrecherU.HighaffinitysaturableuptakeofoxidizedlowdensitylipoproteinbymacrophagesfrommicelackingthescavengerreceptorclassAtypeI/II.JBiolChem.1997;272:12938–12944.LingW,LougheedM,SuzukiH,BuchanA,KodamaT,SteinbrecherUP.Oxidizedoracetylatedlowdensitylipop...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2004年第24卷第1期 -
IdentificationoftheAtypicalL-TypeCa2+ChannelBlockerDiltiazemandItsMetabolitesAsGhrelinReceptorAgonists
...isoformsarewidelyexpressed,withthehighestlevelsofGHSR1afoundinthearcuatenucleusofthehypothalamus,andlowerlevelsincardiactissue(Guanetal.,1997;Gnanapavanetal.,2002).Subsequently,anaturallyoccurringGHSR1aagonistwasidentifiedcalledghrelin(Kojimaetal.,1999).Agreatdealofevidenceexistslinkingghrelin,GHSR1...
醫源資料庫；在線期刊；分子藥理學雜誌；2007年第69卷第8期 -
4-Hydroxy-2-NonenalIncreasesSuperoxideAnionRadicalinEndothelialCellsviaStimulatedGTPCyclohydrolaseProteasomalDegradation
...ecleavageofthefluorogenicsubstrateSuc-LLVY-AMC(chymotrypsin-like)orBoc-Val-Leu-Lys-AMC(trypsin-like)asdescribedinsupplementalmaterial.GSHAssayGSHlevelsweremeasuredbythefluorescentHPLC-basedanalysisof7-fluorobenzo-2-oxa-1,3-diazole-4-sulfonate(SBDF)derivedproductsasdescribedpreviously.27StatisticalAn...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2007年第27卷第11期 -
ProspectiveStudyofNeutrophilChemokineResponsesinTraumaPatientsatRiskforPneumonia
...outcomesaftermajortraumahavebeenrelatedtoplasmalevelsoftheCXCchemokineinterleukin8(IL-8)/CXCL8(12eC14).IL-8bindstobothCXCchemokinereceptor1(CXCR1)andreceptor2(CXCR2).MostCXCchemokines,however,onlybindtothepromiscuousCXCR2(12,13,15eC17).Growth-relatedoncogene(GRO-;CXCL1)isanimportantexampleofthisgrou...
醫源資料庫；在線期刊；美國呼吸和危急護理醫學；2005年第171卷第4期 -
RegulationofEndopeptidasesEC3.4.24.15andEC3.4.24.16inVascularEndothelialCellsbyCyclicStrain:RoleofGiProteinSignaling
...auxC,OrlowskiM.Synaptosomalmembrane-boundformofendopeptidase-24.15generatesLeu-enkephalinfromdynorphin1–8,-and?-neoendorphin,andMet-enkephalinfromMet-enkephalin-Arg6-Gly7-Leu8.JNeurochem.1987;48:282–292.CrackPJ,WuTJ,CumminsPM,FerroES,TullaiJW,GlucksmanMJ,RobertsJL.Theassociationofmetalloendopept...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2004年第24卷第3期 -
變應性鼻炎相關基因研究
...E受體β鏈（FcεRI-β），並報道發現該區有ILE181LEU和GLU237GLY突變［5］，並推測該變異可能增加受體的信號傳遞能力，增加肥大細胞釋放IL-4，並相應刺激高水平的IgE合成，從而引起炎症反應。然而另外很多研究卻發現，...
醫源資料庫；在線期刊；中華醫學研究雜誌；2007年第7卷第11期 -
MutationStudiesofSer7.39andSer2.60intheHumanCB1CannabinoidReceptor:EvidenceforaSerine-InducedBendinCB1TransmembraneHelix7
...asbeenshowntobepartofthebindingpocketforSR141716A(Fayetal.,2005).MutationofLeu3.43ofthehumanCB1(hCB1)receptorwasshowntoincreasetheaffinityofagonistsandreducetheaffinityofinverseagonist,suggestingthatthisresidueplaysaroleinthecouplingbetweentheactiveandrestingstateofthereceptor(D‘Antonaetal.,2006)....
醫源資料庫；在線期刊；分子藥理學雜誌；2007年第69卷第6期 -
TheNeurotransmitterNoradrenalineRescuesSeptalCholinergicNeuronsinCulturefromDegenerationCausedbyLow-LevelOxidativeStress
InstitutNationaldelaSanteeetdelaRechercheMeedicaleUnitee679,ExperimentalNeurologyandTherapeutics,HpitaldelaSalpe簍rieere,Paris,(S.T.,B.S.L.,E.C.H.,P.P.M.)CentredeRecherchePierreFabre,Castres,France(M.M.,F.C.,P.P.M.)AbstractWehavedevelopedamodelsysteminwhichratbasalforebraincholinergicneuronsdegener...
醫源資料庫；在線期刊；分子藥理學雜誌；2005年第67卷第6期 -
RoleoftheAgonistBindingSiteinUp-RegulationofNeuronalNicotinic42Receptors
...aniM,NagayamaC,HamanakaW,MatsunakaY,ItoM,KanekoS,etal.(2002)Mutation(Ser284Leu)ofneuronalnicotinicacetylcholinereceptor4subunitassociatedwithfrontallobeepilepsycausesfasterdesensitizationoftheratreceptorexpressedinoocytes.EpilepsyRes48:181-186.[CrossRef][Medline]MoroniM,ZwartR,SherE,CasselsBK,andBer...
醫源資料庫；在線期刊；分子藥理學雜誌；2006年第68卷第12期 -
GeneticandEnvironmentalDeterminantsofFibrinStructureandFunction
...rinogengenesdescribed.AnexampleisapolymorphisminthefactorXIIIAsubunit(Val34Leu),whichcodesforanaminoacidchangeclosetothethrombincleavagesiteatposition37.FXIIIVal34LeuPolymorphismThesubstitutionofvalinewithleucineisarelativelyconservativeaminoacidchange,butitoccursinanareathatplaysacriticalroleinthei...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2004年第24卷第9期