TheN-terminaldomainofthrombomodulinsequestershigh-mobilitygroup-B1protein,anovelantiinflammatorymechanism
...flammatoryproperties.TM,viaD1,bindshigh-mobilitygroup-B1DNA-bindingprotein(HMGB1),afactorcloselyassociatedwithnecroticcelldamagefollowingitsreleasefromthenucleus,therebypreventinginvitroleukocyteactivation,invivoUVirradiation–inducedcutaneousinflammation,andinvivolipopolysaccharide-inducedlethalit...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第5期RoleofHMGB1inapoptosis-mediatedsepsislethality
...thatZ-VAD-FMK–treatedsepticmicehaddecreasedlevelsofhighmobilitygroupbox1(HMGB1),acriticalcytokinemediatoroforgandamageinseveresepsis,andsuppressedapoptosisinthespleenandthymus.Invitro,apoptoticcellsactivatemacrophagestoreleaseHMGB1.MonoclonalantibodiesagainstHMGB1conferredprotectionagainstorgandam...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第7期StatinTreatmentIsNotAssociatedWithConsistentAlterationsinInflammatoryStatusofCarotidAtheroscleroticPlaques
...ncreaseofplaqueatheroma.1Treatmentwith3-hydroxy-3-methylglutaryl-coenzymeA(HMG-CoA)reductaseinhibitors(statins)clearlyresultsinreducedcardiovascular-relatedmortalityandmorbidity.2,3Nexttothelipid-loweringeffects,statintreatmenthaspotentialpleiotropiceffectsbymodulatingvariousinflammatoryresponsestha...
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第8期兩種降調節方案及降調前不同預處理方法對體外受精結局的影響
...反應情況調整劑量,當主導卵泡直徑≥14mm時,常規75IU的hMG(賀美奇,德國輝凌公司)取代75IU的FSH,卵泡直徑達18~20mm時,停用Gn,當晚注射HCG250μg(艾澤,Serono公司),35~36h後行陰道B超引導下穿刺取卵術。 1.2.3受精 採用本中心常...
醫源資料庫;在線期刊;中華現代婦產科學雜誌;2011年第8卷第1期StatinUseandSex-SpecificStrokeOutcomesinPatientsWithVascularDisease
...8.Amin-HanjaniS,StaglianoNE,YamadaM,HuangP,LiaoJK,MoskowitzMA.Mevastatin,anHMG-CoAreductaseinhibitor,reducesstrokedamageandupregulatesendothelialnitricoxidesynthaseinmice.Stroke.2001;32:980–986.EndresM,LaufsU,HuangZ,NakamuraT,HuangP,MoskowitzMA,LiaoJK.Strokeprotectionby3-hydroxy-3-methylglutaryl(H...
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第6期Influenceofgeneticpolymorphismsonresponsivenesstodietaryfatandcholesterol
...dtherate-limitingenzymeofcholesterolbiosynthesis,hydroxymethylglutaryl-CoA(HMG-CoA)reductase.Thus,thepotentialeffectofdietarycholesteroltoincreaseLDLconcentrationsisoffsetbytheinhibitionofhepaticcholesterolsynthesis.However,in1in4individuals,HMG-CoAreductaseisnotdown-regulatedasefficiently,leadingto...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年72卷第5期ProgressionofCoronaryArteryCalciumandRiskofFirstMyocardialInfarctioninPatientsReceivingCholesterol-LoweringTherapy
...omograph?prognosis?low-densitylipoproteincholesterolIntroductionTherapywithHMG-CoAreductaseinhibitors(statins)hasprovenextremelyusefulinreducingcardiovascularmorbidityandmortalityinprimaryandsecondaryprevention.1–6Despitetheproveneffectivenessofstatinsinreducingtotalandlow-densitylipoprotein(LDL)c...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第7期糖尿病腎病的治療新進展
...化物陰離子的生成加速糖尿病腎病的進展。已有研究發現HMG-CoA還原酶抑制劑對於糖尿病腎病能起到積極的防治作用。涉及的機制通過抑制高糖刺激的RAS-MAPK級聯信號傳遞系統活性而抑制TGF-β的表達,通過TGF-β表達的下調減少細胞...
醫源資料庫;在線期刊;中華現代內科學雜誌;2006年第3卷第4期GM-CSF及性激素水平對卵泡和早期胚胎髮育的影響
...ertilityweretreatedwithIVF-ETundercontrolledhyper-stimulationwithGnRHa/FSH/HMG/HCG.ThefirsttubeofFFwaskeptwhilecollectingoocytes.GM-CSFintheFFandserumweremeasuredbyenzyme-linkedimmunosorbentassay(ELISA)andestradiol(E2),progesterone(P)andluteinizinthormone(LH)concentrationsmeasuredb...
醫源資料庫;在線期刊;齊魯醫學雜誌;2006年第21卷第3期Unchainmyheart:thescientificfoundationsofcardiacrepair
...inistrationenhancethenumberofcirculatingEPCsinadults,includingtreatmentwithHMGCoAreductaseinhibitors(statins)andestrogensaswellasexercise(57-59).Moststudiesconfirmedanimprovementinendothelialregenerationorneovascularizationbymobilizingagents.However,suchfunctionalimprovementsmaynotrelyentirelyonEPCm...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期