MolecularChangesEvokedbyTriethylenetetramineTreatmentintheExtracellularMatrixoftheHeartandAortainDiabeticRats
...peuticoptions.FreeCu2+ionsarestronglypro-oxidant,andchelatable-CuIIisincreasedinthediabeticheart.WereportedpreviouslythattreatmentbyCuII-selectivechelationwithtriethylenetetramine(TETA)evokeselevatedurinaryCuIIindiabeticratsandhumansinwhomitalsoimprovedhallmarksofestablishedleftventricular(LV)diseas...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期二甲雙胍聯合吡格列酮治療初發肥胖2型糖尿病的療效觀察
...Clinicalobservationofmetformincombinedwithpioglitazoneintreatingnewlydiagnosedobesitytype2diabetespatientsQIAOJing,ZHOURui-xiu,MAXiao-li,etal.ThePeople’sHospitalofGaomiCity,Gaomi261500,China【Abstract】ObjectiveToobservethetherapeuticeffectofmetformincombinedwithpioglitazoneonglycemia,lipi...
醫源資料庫;在線期刊;中華醫學實踐雜誌;2009年第8卷第2期AIF-1ExpressionModulatesProliferationofHumanVascularSmoothMuscleCellsbyAutocrineExpressionofG-CSF
...sisandWesternblottingonserum-starvedAIF-1–transducedVSMCsidentifiedincreasedmRNAexpressionofseveralcellcycleproteinsand,surprisingly,thecytokineG-CSF.AdditionofG-CSFcauseda75%increaseinproliferationofVSMCsintheabsenceofserumgrowthfactors.TheproliferativeeffectsofAIF-1wereabrogatedbyneutralizingant...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第7期GeneticSusceptibilityandRelationshiptoChronicObstructivePulmonaryDisease
...idualswithafamilyhistoryoflungcancerareatapproximatelytwo-tothreefoldincreasedriskofdevelopingthisdisease(reviewedinReferences5–7).Thisarticleattemptstoplaceincontextforthepracticingpulmonaryspecialistandinternisttheroleoffamilialriskinlungcancerandtosuggestanimportantlinkagetofamilialriskforchron...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2006年第173卷第1期Fibroblastgrowthfactor-23increasesmousePGE2productioninvivoandinvitro
...B6mouserenalproximaltubuleswithFGF-23R176Q,anactivemutantformofFGR23,increasedtubularPGE2production,aneffectthatwasinhibitedby50μMPD-98059and10μMSB-203580,inhibitorsoftheMAPkinasepathway.C57/B6miceinjectedwithFGF-23R176Qhada10-foldincreaseinPGE2excretion24hafterintraperitonealinjectionofFGF-23R176...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第3期ExerciseCanPreventandReversetheSeverityofHypertrophicCardiomyopathy
...CMpathology.IfinitiatedinolderHCManimalswithdocumenteddisease,exercisereversedmyocytedisarray(butnotfibrosis)and“hypertrophic“markerinduction.Inaddition,exercisereturnedtheincreasedlevelsofphosphorylatedGSK-3tothoseofNTGanddecreasedlevelsofphosphorylatedCREBinHCMmicetonormallevels.ExerciseinHCMm...
醫源資料庫;在線期刊;循環研究雜誌;2006年第96卷第3期Flavonoidintakeandtheriskofcardiovasculardiseaseinwomen
...151;includingquercetin,kaempferol,myricetin,apigenin,andluteolinwasbasedonfoodtablesmaintainedbytheDepartmentofNutrition,HarvardSchoolofPublicHealth,Boston.Totalflavonoidsrepresentthesumoftheindividualselectedflavonolsandflavones.ThefoodtableswereoriginallygeneratedintheNetherlandsandlatersupp...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年77卷第6期TransformingGrowthFactor-ß-InducedExpressionoftheApolipoproteinEGeneRequiresc-JunN-TerminalKinase,p38Kinase,andCaseinKinase
...orofcellularcholesteroleffluxandreversecholesteroltransport.14TheapoEexpressedbymonocytes/macrophageshaspotentantiatherogenicproperties.14BecauseofsuchantiatherogenicactionsofapoEandTGF-ß,thepresentstudywasaimedatinvestigatingtheregulationofapoEexpressioninmonocytesandmacrophagesbyTGF-ßa...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第6期IncreasedglomerularpermeabilitytonegativelychargedFicollrelativetoneutralFicollinrats
【摘要】Itisestablishedthattheglomerularfiltersievesmacromoleculesbasedontheirsize,shape,andcharge.Anionicproteinsarethusretardedcomparedwiththeirneutralorcationiccounterparts.However,recentstudieshaveindicatedthatchargeeffectsaresmall,orevenanomalous,forpolysaccharides.Wethereforeinvestigatedth...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第11期Comparisonoftheeffectivenessof2dual-energyX-rayabsorptiometerswiththatoftotalbodywaterandcomputedtomographyinassessingchangesinbodycomp
...ngeinLSTMwiththefanandpencilbeamsprovidesthesamerelationtochangesinFFMassessedbyTBW,butthe2systemsarenotinterchangeable.KeyWords:Bodycompositiondual-energyX-rayabsorptiometryDXAcomputedtomographyweightlossleanbodymassfatmasstotalbodywaterINTRODUCTIONTheabili...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年77卷第2期