CharacterizationofaNovelPKAPhosphorylationSite,Serine-2030,RevealsNoPKAHyperphosphorylationoftheCardiacRyanodineReceptorinCanineHeartFailu
...eenproposedtobeakeymechanismresponsibleforcardiacdysfunctioninheartfailure(HF).However,thesitesofPKAphosphorylationinRyR2andtheirphosphorylationstatusinHFarenotwelldefined.HereweusedvariousapproachestoinvestigatethephosphorylationofRyR2byPKA.Mutatingserine-2808,whichwasthoughttobetheonlyPKAphosphory...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期Sugars,energymetabolism,andbodyweightcontrol
...ichleadstofatstorage.Althoughthedenovosynthesisisrelativelysmallcomparedwithfatstorage,thelong-termmetabolicconsequencescouldbeimportant.Furtherstudiesarerequiredtoprovideabetterunderstandingofthisphenomenon.Itisinterestingthat,inthiswell-designedstudy,asurplusofcarbohydrateintheformofglucoseorsucro...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年78卷第4期ArrhythmogenicMutation-LinkedDefectsinRyanodineReceptorAutoregulationRevealaNovelMechanismofCa2+ReleaseChannelDysfunction
...nalsafteradditionofcaffeine(0.1to30mmol/L)tocells.AnalysiswasperformedbybothFratiotestonlog-transformeddata,asthemeansignallevelsbeforeandaftercaffeinestimulationwereverydifferent,andbycalculatingtherelativesignalvariability(RSV).TheRSVrepresentstherelativevariabilityinamplitudeandtemporalpatterning...
醫源資料庫;在線期刊;循環研究雜誌;2006年第96卷第1期Ca2+/CalmodulineCDependentProteinKinaseModulatesCardiacRyanodineReceptorPhosphorylationandSarcoplasmicReticulumCa2+LeakinHeartFailure
...yR2)maycontributetocontractiledysfunctionandarrhythmogenesisinheartfailure(HF).WepreviouslydemonstrateddecreasedCatransientamplitudeandSRCaloadassociatedwithincreasedNa/CaexchangerexpressionandenhanceddiastolicSRCaleakinanarrhythmogenicrabbitmodelofnonischemicHF.Hereweassessedexpressionandphosphoryl...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第12期2010:《Science》的中國聲音
...通過高解析度測量碰撞能和不同微分截面觀察到了F+HD→HF+D反應單分波共振,並提供一個F+HD→HF+D過渡態的光譜探針。我們的數據與高級理論運算結果相一致,這證明該探針對引導貝克曼反應的微量子機制因子的敏感性。 譯...
醫學教育;科教新聞TargetedDisruptionofSmad4inCardiomyocytesResultsinCardiacHypertrophyandHeartFailure
...inghuaUniversity,Beijing,People’sRepublicofChinaAbstractTransforminggrowthfactor-s(TGF-s)arepleiotropiccytokinesinvolvedinmanyphysiologicalandpathologicalprocesses,includingheartdevelopmentandheartdisease.Smad4isthecentralintracellularmediatorofTGF-signaling.ToinvestigatethefunctionofSmad4inheartd...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第10期Drusendepositsassociatedwithagingandage-relatedmaculardegenerationcontainnonfibrillaramyloidoligomers
...idoligomersindrusenandthickenedBm.Amyloidoligomerreactivitywasvisualizedwithfluorescein(green),andlipofuscinautofluorescencewasvisualizedusingtheCy3channel(red).Multipleamyloidoligomercoresweresometimesobservedinlargedrusen(AandB),asifalargedrusemayhaveformedfromthefusionofseveralsmallerdrusen.Theam...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期ASAGE-basedcomparisonbetweenglomerularandaorticendothelialcells
...adedthetumorsatdifferentratesbecauseofdifferencesinvascularendothelialgrowthfactor(VEGF)receptorexpression(31).Thisstronglysuggeststhatthemicroenvironmentinfluencesendothelialcellphenotype,yetthetranscriptionalrepertoireofendothelialcellsdoesnotrevertfullytoacommonphenotypewhenthecellsencounterthesa...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第6期Epac-mediatedCa2+mobilizationandexocytosisininnermedullarycollectingduct
...olsapprovedbytheInstitutionalAnimalCareandUseCommitteeattheUniversityofSouthFlorida,inaccordancewithPublicHealthServicePolicyonHumanCareandUseofLaboratoryAnimals.ExperimentswereconductedinIMCDisolatedfrommaleSprague-Dawleyrats(60-100gbodywt,Harlan).Theratsweretreatedwithfurosemideintraperitoneally(5...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第10期InvolvementoftheEdarSignalingintheControlofHairFollicleInvolution(Catagen)
...edfornormaldevelopmentofseveralectodermalderivativesincludinghairfollicles(HFs).Here,weshowthatduringthemurinehaircycletheexpressionofEdaA1,Edar,Edaradd,andTRAF6transcriptsareminimalintherestingphaseandmaximalduringHFtransitionfromactivegrowthtoregression(catagen).EdaA1mRNAandEdarproteinswereexpress...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第12期