Effectsoftomatoextractonplateletfunction:adouble-blindedcrossoverstudyinhealthyhumans
...duetocoronaryarterydisease(CAD)canoccurasaresultofanacutethromboticeventcausedbytheruptureofanatheroscleroticplaque(2,8).Insupportofthepathophysiologicroleofplatelets,therapywithantiplateletagentshasbeenshowntosignificantlydecreasetheincidenceofprimaryandsecondarycoronaryeventsrelatedtocardiovascula...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年84卷第3期EffectofBronchoscopicLungVolumeReductiononDynamicHyperinflationandExerciseinEmphysema
...foreand4weeksafterunilateralvalveinsertion,functionalresidualcapacitydecreasedfrom7.1(1.5)to6.6(1.7)L(p=0.03)anddiffusingcapacityrosefrom3.3(1.1)to3.7(1.2)mmol·minuteeC1·kPaeC1(p=0.03).Cycleendurancetimeat80%ofpeakworkloadincreasedfrom227(129)to315(195)seconds(p=0.03).Thiswasassociatedwithareducti...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第3期OxidativeStressandVascularDisease
...hypertension,stroke,diabetes,andheartfailure,expressionofsuperoxideisincreasedinbloodvessels,andendothelialvasomotorfunctionisimpaired,presumablycausedinlargepartbyinactivationofnitricoxidebysuperoxide.Endothelialdysfunctionispredictiveofcardiovascularrisk,andprobablyplaysakeyroleinthepathophysiolog...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第4期AttenuationofBleomycin-inducedPulmonaryFibrosisbyFollistatin
...reatedratlung,mRNAfortheAsubunitofactivinwasupregulatedonDays3and7anddecreasedgraduallythereafter.ImmunoreactiveactivinAwasabundantlyexpressedinmacrophagesinfiltratedinthelung,andwasdetectedinfibroblastsaccumulatedinthefibroticareaonDay28.Wethenadministeredfollistatin,anactivinantagonist,toBLM-treat...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第9期PhylogeneticCharacterizationofCanineDistemperVirusesDetectedinNaturallyInfectedDogsinNorthAmerica
...rpremisesweresubjectedtonecropsyevaluation.Forfiveofthesevendogs,diseasecausedbycaninedistempervirus(CDV)infectionwassuspectedbasedonclinicalsigns.Inallofthedogs,adiagnosisofCDVinfectionwasestablishedbythepresenceofcompatiblegrossandhistologiclesions,immunohistochemicallabelingforCDVantigen,anddetec...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期ImpactofKaposiSarcomaAssociatedHerpesvirus(KSHV)BurdenandHIVCoinfectionontheDetectionofTCellResponsestoKSHVORF73andORF65Proteins
...alagentofKSandseveralothermalignancies,areincompletelycharacterized.WeassessedKSHV-specificinterferon-enzyme-linkedimmunospotresponsesinacohortof154individuals,usingoverlappingpeptidesetsspanningtheKSHV-encodedlatency-associatednuclearantigen(ORF73)andtheminorcapsidglycoprotein(ORF65).AmongKSHV-sero...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第16期PravastatinInhibitsExpressionofLectin-LikeOxidizedLow-DensityLipoproteinReceptor-1(LOX-1)inWatanabeHeritableHyperlipidemicRabbits
...nsareabletodownregulateLOX-1expressioninvitro,weexaminedifpravastatincanbeusedtoreduceLOX-1expressionandlipidcoreformationinlesionsofWatanabeheritablehyperlipidemic(WHHL)rabbits.MethodsandResults-PravastatindownregulatedLOX-1expressioninculturedhumanMsandinculturedhumanaorticSMCs.HomozygousWHHLrabbi...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第3期Irondeficiencyduetoconsumptionofahabitualdietlowinbioavailableiron:alongitudinalcohortstudyinMoroccanchildren
...thz.ch.ABSTRACTBackground:Inmanydevelopingcountries,cerealandlegumebaseddietscontainlowamountsofbioavailableiron,whichmayincreasetheriskofirondeficiency.Objective:TheobjectivewastomeasurechangeinironstatusinMoroccanchildrenwhoconsumedtheirhabitualdietcontaininglowamountsofbioavailableiron.Desi...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年81卷第1期Pre-B-CellLeukemiaTranscriptionFactorRegulatesExpressionofValosin-ContainingProteinaGeneInvolvedinCancerGrowth
...retransfectedintoMCF7mammarycarcinomacellline,inwhichVCPwasabundantlyexpressed.Thedeletionandmutationatthetwobindingmotifsforpre-B-cellleukemiatranscriptionfactor1(PBX1)reducedtheluciferaseactivity,indicatingthatthesetwoPBX1motifsmediatedthetransactivationoftheVCPgene.Chromatinimmunoprecipitationass...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第1期VascularHemeOxygenase-1InductionSuppressesMicrovascularThrombusFormationInVivo
...1activitymaybeofpreventiveandtherapeuticvalueforclinicaldisorderswithincreasedriskofthromboticevents.KeyWords:thrombosis?fluorescencemicroscopy?carbonmonoxide?bilirubin?P-selectinIntroductionThromboembolismisstillamajorprobleminalmostallfieldsofclinicalmedicine,resultingintissueinfarctionandischemic...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第3期