InteractionoftheInsulinReceptorwiththeReceptor-LikeProteinTyrosinePhosphatasesPTPandPTPinLivingCells
...energytransfer.Inhumanembryonickidney293cellsexpressingtheinsulinreceptorfusedtoluciferaseandsubstrate-trappingmutantsofPTPorPTPfusedtothefluorescentproteinTopaz,insulininducesanincreaseinresonanceenergytransferthatcouldbefollowedinrealtimeinlivingcells.Insulineffectcouldbedetectedatveryearlytimepoi...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第4期QuantitativeTraitLociforApolipoproteinB,Cholesterol,andTriglyceridesinFamilialCombinedHyperlipidemiaPedigrees
...lcombinedhyperlipidemia(FCHL)isageneticallycomplexlipiddisorderthatisdiagnosedinfamiliesbycombinationsofincreasedcholesterol,triglycerides,and/orapolipoproteinB(apoB)levelsinpatientsandtheirfirst-degreerelatives.Identifyingthepredisposinggenespromisestorevealtheprimaryriskfactorsandsusceptibilitypat...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第10期Measurementofmagnesiumabsorptionandretentionintype2diabeticpatientswiththeuseofstableisotopes
...esiumstatusindiabeticpatientsinSwitzerland(10).Severalstudiesreportedincreasedurinarymagnesiumexcretionintype1and2diabetes(6,1115),whereasotherstudiesfoundnosignificantdifferencesinmagnesiumexcretionbetweendiabeticpatientsandhealthycontrolsubjects(16,17).Severalauthorshavesuggestedthatimpaired...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年78卷第3期MucosalLymphoidInfiltrateDominatesColonicPathologicalChangesinMurineExperimentalShigellosis
...oughMcellsofthefollicle-associatedepitheliumthatcoverslymphoidnodulesdispersedonthecolorectalsurface[4].Fromthere,shigellaepenetrateintestinalepithelialcells(IECs),inwhichtheyinjecteffectorproteinsviaatypeIIIsecretionapparatus[5].Theseeventsinitiateinflammationthroughtheapoptotickillingofinfectedmac...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第13期EffectofmultiplemicronutrientsupplementationduringpregnancyoninflammatorymarkersinNepalesewomen
...sindicateanassociationbetweensystemicinflammationinlatepregnancyandcompromiseddeliveryoutcomeinNepalesewomenbutdonotsupportthehypothesisthatmultiplemicronutrientsupplementationchangescytokineproductionorinflammatorymarkers.KeyWords:Micronutrientspregnancycytokineinflammationi...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年84卷第5期預構皮瓣的研製及其進展
...toaxialpatternskinflap,thusthechoiceofthedonorsiteofthefreeskinflapisincreased.Soasanewtechniqueandadvanceinthefieldofplasticsurgerytheprefabricatedskinflaphasbeenacceptedwidely. In1994JulianJ.Pribazproposedthatprefabricationshouedberestrictedtoitsoriginalmeaningi.e.theimplantationofavascularpe...
合作平臺;醫學論文;外科論文;燒傷外科學ValidationofapXO2-APCRAssayToExploreDiversityamongItalianIsolatesofBacillusanthracisStrainsCloselyRelatedtotheLive,AttenuatedCarbosapVa
...tenuatedvaccinestrain,containingbothpXO1andpXO2plasmids.Thegenotypewasassessedbyusingeight-locusmultilocusvariable-numbertandemrepeatanalysis.Wedescribeheretheuseofaninthlocusabletoexplorevariabilityamongstrainsthathavethesamegenotype.ItisimportanttobeabletogenotypethewildisolateofB.anthracisstrains...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第9期ViciousandVirtuousCirclesintheDynamicsofInfectiousDiseaseandtheProvisionofHealthCare:GonorrheainBritainasanExample
...[2].Thesupplyofgenitourinarymedicine(GUM)serviceshasnotkeptupwiththisincreaseddemand,whichhasledtotreatmentservicesbecomingoverstretched.MostGUMclinicsnolongerofferwalk-inaccess,andtypicalwaitingtimesforGUMserviceshaveincreasedoftentoweeksforaninitialconsultation[36]whichinevitablymeansthatsomepatie...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第17期Aproinflammatorystateisassociatedwithhyperhomocysteinemiaintheelderly
...termediaterange1530µmol/L(oddsratio:1.6;95%CI:1.2,2.2;P=0.0014).Sedentarystate,intakesofvitaminB-6andfolicacid,andserumfolate,vitaminB-12,vitaminB-6,and-tocopherolconcentrationsweresignificantindependentcorrelatesofhomocysteine.Conclusions:HighcirculatingconcentrationsofIL-1raandIL-6arein...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年82卷第2期TNF-ContributestoEndothelialDysfunctioninIschemia/ReperfusionInjury
.../reperfusion(I/R)injury.Becausetumornecrosisfactor-(TNF-)isreportedlyexpressedduringischemiaandcaninducevascularinflammationleadingtoendothelialdysfunction,wehypothesizedthatthisinflammatorycytokinemayplayapivotalroleinI/Rinjury-inducedcoronaryendothelialdysfunction.MethodsandResults-Totestthishypot...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第3期