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TheSizeofaSingleResidueoftheSulfonylureaReceptorDictatestheEffectivenessofKATPChannelOpeners
...7andashortsegmentofNBD2(Uhdeetal.,1999);finally,tworesidueswithinTMhelix17(Leu1249andThr1253inSUR2A,Thr1286andMet1290inSUR1)wereshowntobenecessary(whenmutatedinSUR2A,lossofopeneractionensued)andsufficientsincemutationofanyoftheseresiduescouldconfertoSUR1asensitivitytoopenersthatwaseitherpartialinthe...
醫源資料庫；在線期刊；分子藥理學雜誌；2005年第67卷第4期 -
EmergenceofFluconazoleResistanceinaCandidaparapsilosisStrainThatCausedInfectionsinaNeonatalIntensiveCareUnit
...nt-daysintheNICUannuallywereobtainedfromthehospitaladministration.Fluconazoleusewasassessedbasedonthehospitalpharmacyrecords,calculatedasthenumberofgramsdeliveredtotheNICUannually.Fluconazoleprophylaxispolicyandothercontrolmeasures.Duringtheearlieroutbreak,whichoccurredfrom1987to1991(27),fluconazole...
醫源資料庫；在線期刊；微生物臨牀雜誌；2005年第43卷第6期 -
藥物代謝酶CYP1家族相關基因的研究進展
...是由於第558位的C→A突變引起氨基酸第186位由Phe（F）到Leu（L）的改變,導致酶活性降低。CYP1A2*7是由於第3534位的G→A突變引起剪切缺陷。2.1CYP1A2催化代謝的藥物CYP1A2催化代謝的藥物有非那西丁、咖啡因、茶鹼、氯氮平、普萘...
醫源資料庫；在線期刊；中華醫藥雜誌；2007年第7卷第8期 -
Platelet-MonocyteComplexesSupportMonocyteAdhesiontoEndotheliumbyEnhancingSecondaryTetheringandClusterFormation
...etweentheinflammatoryandhemostaticresponsesasindicatedbythecolocalizationofleukocytes,platelet,andfibrindepositionsarealsoconsideredessentialinthisprocess.Thepowerfuladhesiveinteractionsthatarerequiredformonocytestowithstandlocalflowatthevesselwallcanbedescribedasamultistepprocessmediatedbydifferent...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2004年第24卷第1期 -
UseofaThree-DimensionalMicroarraySystemforDetectionofLevofloxacinResistanceandthemecAGeneinStaphylococcusaureus
...inedbytheDNAsequencerandwereassociatedwithaminoacidsubstitutionssuchasSer84Leu,Ser85Pro,andGlu88LysinGyrA;Ser80Phe,Ser80Tyr,andGlu84LysinGrlA;andPro451SerinGrlB(Table3).Double-pointmutationssuchasthosecorrespondingtoSer84LeuandSer85ProinGyrAweredetectedusingonlyasingleprobe.Aftercalculationofthecros...
醫源資料庫；在線期刊；微生物臨牀雜誌；2005年第43卷第10期 -
MastCellChymaseInducesSmoothMuscleCellApoptosisbyaMechanismInvolvingFibronectinDegradationandDisruptionofFocalAdhesions
...bondsatthecarboxylterminusofaromatic(Phe,Tyr,Trp)orbranched-chainaliphatic(Leu,Ile,Val)aminoacids.Accordingly,chymasehasbeenshowntoproteolyzeseveraltypesofmoleculespresentinthearterialintima,suchasmatrixmetalloproteinases,11transforminggrowthfactor-ß,12angiotensinI,13apolipoproteins,14andsever...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2003年第23卷第2期 -
CharacterizationofCytokine/ChemokineProfilesofSevereAcuteRespiratorySyndrome
...acrophageinfiltrationanddepletionoflymphocyteswereobserved.Thelevelsofinterleukin-6,interleukin-8,andmonocytechemoattractantprotein-1wereconcomitantlyincreasedinthebloodofthepatientswithsuperinfection,andthemRNAsforthesecytokineswerealsoincreasedinlungtissues.Conclusions:InductionofIP-10isacriticale...
醫源資料庫；在線期刊；美國呼吸和危急護理醫學；2005年第171卷第4期 -
MineralocorticoidReceptorBlockerIncreasesAngiotensin-ConvertingEnzyme2ActivityinCongestiveHeartFailurePatients
...ionwasamodificationofthemethoddescribedbyHuangetal.20Briefly,ACE2cleavestheleucineattheC-terminalofthedecapeptideangiotensinI(Asp1Arg2Val3Tyr4Ile5His6Pro7Phe8His9Leu10)andtheassayisbasedonmeasurementoffreeleucinereleased.Withtheadditionof-nicotinamideadeninedinucleotideandleucinedehydrogenase(LeuDH)...
醫源資料庫；在線期刊；循環研究雜誌；2005年第95卷第10期 -
Theconedysfunctionsyndromes
...te.However,fourmutationsinparticular(Arg277Cys,Arg283Trp,Arg436TrpandPhe547Leu)arefoundmostcommonly,accountingforapproximately40%ofallmutantCNGA3alleles.13Moreover,subsequentanalysisofthehomologousCNGA3knockoutmousemodelshowedcompleteabsenceofphysiologicallymeasurableconefunction,adecreaseinthenumbe...
醫源資料庫；在線期刊；英國眼科學雜誌；2004年第88卷第2期 -
PlateletActivity,Coagulation,andFibrinolysisDuringExerciseinHealthyMales
...elet-plateletmicroaggregates,theplateletresponsivenesstoinvitrostimulation,leukocyteactivation(leukocyteCD11bexpressionandplasmaelastase),andplatelet-leukocyteaggregation(P0.01forall).Exerciseincreasedcoagulation(F1+2;P0.01)andfibrinolysis,butdidnotalterthebalancebetweenthem;fibringelpermeabilityinc...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2007年第27卷第2期