ComplementreceptorsregulatedifferentiationofbonemarrowplasmacellprecursorsexpressingtranscriptionfactorsBlimp-1andXBP-1
...emory,weanalyzedtheresponseagainstviralparticlesderivedfromthebacteriophageQinmicedeficientinCD21–CD35(Cr2–/–).Despitehighlyefficientinductionofearlyantibodyresponsesandgerminalcenter(GC)reactionstoimmunizationwithQ,Cr2–/–miceexhibitedimpairedantibodypersistenceparalleledbyastronglyreduced...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第6期MolecularEpidemiologyofMethicillin-ResistantStaphylococcusaureusinZürich,Switzerland(2003):PrevalenceofTypeIVSCCmecandaNewSCCmecElementAss
...ettechromosomemectypeIV(SCCmec-IV),harboredbyhalfoftheisolates,wasfoundinsequencetype217(ST217),whichisanallelicvariantofepidemicMRSA-15(designatedEMRSA-15),inanewlocalST617descendingfromclonalcomplexCC8andinlow-leveloxacillin-resistantstrainsofmultiplegeneticlineagescharacteristicofcommunity-onsetM...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期Intrarenalcells,notbonemarrow–derivedcells,arethemajorsourceforregenerationinpostischemickidney
...lysisusingcre/loxPrecombination.TheZ/EGdoublereportermousestraincarriesaubiquitouspromoterlinkedtoalacZgenethatisflankedby2loxPsitesandanenhancedGFP(EGFP)reportergenethatresidesfurtherdownstream(24).Intheabsenceofcrerecombinase,lacZisexpressedinmosttissues,includingkidneycells.Inthepresenceofcrereco...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第7期HelperTcelldifferentiationentersanewera:LeRoiestmort;viveleRoi!
...ellularpathogens,whereaseradicationofhelminthicinfestationsisdependentonadequateTh2responses.However,theimmunopathogenesisofautoimmunediseasedoesnotfitquitesoneatlyintothisdichotomy.CD4+TcellscanalsodifferentiateintocellsthatproducetheimmunosuppressivecytokinesIL-10andTGF,so-calledTh3cells,andcanbec...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期MSH2–MSH6stimulatesDNApolymerase,suggestingaroleforA:Tmutationsinantibodygenes
...smthatgeneratesmutationsatA:Tbasepairs,however,remainsunclear.ItappearstorequiretheMSH2–MSH6mismatchrepairheterodimerandDNApolymerase(pol),asmutationsofA:Taredecreasedinmiceandhumanslackingtheseproteins.Here,wedemonstratethattheseproteinsinteractphysicallyandfunctionally.First,weshowthatMSH2–MSH...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第4期ReawakeningthecellulardeathprograminneoplasiathroughthetherapeuticblockadeofIAPfunction
...ymembersalsoharboraRINGdomainatthecarboxyterminus.TheRINGfunctionsasanE3ubiquitinligase,whichisprecededbyubiquitin-activatingenzymes(E1)andubiquitin-conjugatingenzymes(E2)inthecascadeofproteinubiquitination(6-9).E3ubiquitinligasesprovidespecificityforthetransferofubiquitinmoietiesontothetargetprotei...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期RapidandSensitiveDetectionofSevereAcuteRespiratorySyndromeCoronavirusbyRollingCircleAmplification
...A),wewereabletoachievesensitivedetectionlevelsofSARS-CoVRNAinbothsolidandliquidphases.ThemainadvantageofRCAisthatitcanbeperformedunderisothermalconditionswithminimalreagentsandavoidsthegenerationoffalse-positiveresults,aproblemthatisfrequentlyencounteredinPCR-basedassays.Furthermore,theRCAtechnology...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第5期ImpactofDNAligaseIVonnonhomologousendjoiningpathwaysduringclassswitchrecombinationinhumancells
...nducedcytidinedeaminase(AID).Theinitiallesionsintheswitch(S)regionsaresubsequentlyprocessedandresolved,leadingtorecombinationofthetwotargetedSregions.ThemechanismsbywhichrepairandligationofthebrokenDNAendsoccursisstillelusive.Recently,asmallnumberofpatientslackingDNAligaseIV,acriticalcomponentofthen...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第2期ProtectionfromAlzheimer‘s-likediseaseinthemousebygeneticablationofinduciblenitricoxidesynthase
...fiNOSsubstantiallyprotectedtheAD-likemicefromprematuremortality,cerebralplaqueformation,increased-amyloidlevels,proteintyrosinenitration,astrocytosis,andmicrogliosis.Thus,iNOSseemstobeamajorinstigatorof-amyloiddepositionanddiseaseprogression.InhibitionofiNOSmaybeatherapeuticoptioninAD.Alzheimer‘sd...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第9期OligonucleotideLigationAssayforDetectionofMutationsAssociatedwithReverseTranscriptaseandProteaseInhibitorResistanceinNon-BSubtypesandRecomb
...danddevelopedfornon-Bsubtypesandrecombinantstrainsandhasbeenevaluatedwithsequencing,resultinginamoresensitiveassaythansequencingfornon-Bsubtypes.TEXTMethodstoidentifyresistancemutationsinthehumanimmunodeficiencyvirustype1(HIV-1)polgeneareneededsincetheuseofprotease(PR)and/orreversetranscriptase(RT)i...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期