MutationofthephospholipaseC-1–bindingsiteofLATaffectsbothpositiveandnegativethymocyteselection
...equiredforlinkerforactivationofTcellfunction.J.Biol.Chem.276:29588–29595.Paz,P.E.,S.Wang,H.Clarke,X.Lu,D.Stokoe,andA.Abo.2001.MappingtheZap-70phosphorylationsitesonLAT(linkerforactivationofTcells)requiredforrecruitmentandactivationofsignallingproteinsinTcells.Biochem.J.356:461–471.Sommers,C.L.,R...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第7期KahalalideFInducesNecrosis-LikeCellDeaththatInvolvesDepletionofErbB3andInhibitionofAktSignaling
...OHkinasesignaltransduction.Nature(Lond)376:599-602.CiruelosC,TrigoT,PardoJ,Paz-AresL,EstaunN,CuadraC,DomeguezM,MareA,JimenoJM,andIzquierdoM(2002)AphaseIclinicalandpharmokinetic(PK)studywithkahalalideF(KF)inpatients(Pts)withadvancedsolidtumors(AST)withacontinuousweekly(W)1-hourIVinfusionschedule.EurJ...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第2期Inflammation,stress,anddiabetes
...swiththeinsulinreceptorandinhibitsinsulinaction.J.Biol.Chem.277::1531-1537.Paz,K.etal.1997..Amolecularbasisforinsulinresistance.Elevatedserine/threoninephosphorylationofIRS-1andIRS-2inhibitstheirbindingtothejuxtamembraneregionoftheinsulinreceptorandimpairstheirabilitytoundergoinsulin-inducedtyrosine...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第5期調控基因表達的miRNA
...研究可以和siRNA的作用相結合起來,近來關於Argonaute蛋白PAZ結構域晶體結構的測定揭示了RISC與RNA結合的作用機制。當然miRNA抑制機制的揭示有待於miRNA領域的深入研究。4.2miRNA的功能 miRNA是一種廣泛存在的對基因表達進行微調...
行業資訊;臨牀快報;RNA研究GeneticDiversityamongTypeemm28GroupAStreptococcusStrainsCausingInvasiveInfectionsandPharyngitis
...-Goor,J.Jaffe,I.Shetzigovsky,M.Ravins,Z.Korenman,R.Cohen-Poradosu,andR.Nir-Paz.2003.emmtypingofMnontypeableinvasivegroupAstreptococcalisolatesinIsrael.J.Clin.Microbiol.41:4655-4659.Muller,M.P.,D.E.Low,K.A.Green,A.E.Simor,M.Loeb,D.Gregson,A.McGeer,andtheOntarioGroupAStreptococcalStudy.2003.Clinicalan...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期DNAEnzymesShortInterferingRNAandtheEmergingWaveofSmall-MoleculeNucleicAcid-BasedGene-SilencingStrategies
...ngdosestudyofalicaforsenenemainactiveulcerativecolitis.Gut2004,53:1646-1651Paz-AresL,DouillardJY,KoralewskiP,ManegoldC,SmitEF,ReyesJM,ChangGC,JohnWJ,PetersonPM,ObasajuCK,LahnM,GandaraDR:PhaseIIIstudyofgemcitabineandcisplatinwithorwithoutaprinocarsen,aproteinkinaseC-antisenseoligonucleotide,inpatient...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第10期SecondClassMinors
....A.Janeway,Jr.1991.Onthecomplexityofself.Nature.353:660–662.Mendoza,L.,P.Paz,A.R.Zuberi,G.Christianson,D.C.Roopenian,andN.Shastri.1997.Minorsheldbymajors.TheH13minorhistocompatibilitylocusdefinedasapeptide/MHCclassIcomplex.Immunity.7:461–472.Vogt,M.H.,J.W.vandenMuijsenberg,E.Goulmy,E.Spierings,P...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第3期SecondClassMinorsMolecularIdentificationoftheAutosomalH46HistocompatibilityLocusasaPeptidePresentedbyMajorHistocompatibilityComplexClassII
....A.Janeway,Jr.1991.Onthecomplexityofself.Nature.353:660–662.Mendoza,L.,P.Paz,A.R.Zuberi,G.Christianson,D.C.Roopenian,andN.Shastri.1997.Minorsheldbymajors.TheH13minorhistocompatibilitylocusdefinedasapeptide/MHCclassIcomplex.Immunity.7:461–472.Vogt,M.H.,J.W.vandenMuijsenberg,E.Goulmy,E.Spierings,P...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第3期EssentialRolesoftheCCChemokineLigand-CCChemokineReceptorAxisinBleomycin-InducedPulmonaryFibrosisthroughRegulationofMacrophageandFibrocyte
...spiratorySociety(ERS).AmJRespirCritCareMed2000,161:646-664ChabnerBA,RyanDP,Paz-AresL,Garcia-CarboneroR,CalabresiP:Antineoplasticagents.HardmanJGLimbirdLEeds.ThePharmacologicalBasisofTherapeutics,ed102003:pp1429-1430McGraw-Hill,NewYorkBowdenDH:Unravelingpulmonaryfibrosis:thebleomycinmodel.LabInvest19...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第3期DeletionofSOCS7leadstoenhancedinsulinactionandenlargedisletsofLangerhans
...eptorsubstrate1byinhibitorkappaBkinasecomplex.J.Biol.Chem.277::48115-48121.Paz,K.etal.1997..Amolecularbasisforinsulinresistance.Elevatedserine/threoninephosphorylationofIRS-1andIRS-2inhibitstheirbindingtothejuxtamembraneregionoftheinsulinreceptorandimpairstheirabilitytoundergoinsulin-inducedtyrosine...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第9期