IntegrationofVirtualScreeningwithHigh-ThroughputFlowCytometrytoIdentifyNovelSmallMoleculeFormylpeptideReceptorAntagonists
...-coupledreceptorscontributestothelocalizationandactivationoftissue-damagingleukocytesatsitesofchronicinflammation.WedevelopedaFPRhomologymodelandpharmacophore(basedonthebovinerhodopsincrystalstructureandknownFPRligands,respectively)forinsilicoscreeningof480,000drug-likesmallmolecules.Asubsetof4324co...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第5期第七節 真皮浸潤細胞免疫表達
...達 一、T淋巴細胞及其亞羣的免疫表達 CD3(OKT3,Leu4)對T細胞特異,正常或腫瘤性B細胞不表達CD3;CD4RO(UCHL1)大多數T細胞和T細胞淋巴瘤呈陽性表達,能用於石蠟切片中。二者是常規篩選T細胞的良好標記物。成熟T細胞...
醫源資料庫;醫源圖書館;教材類;實用免疫細胞與核酸ExtracellularLoop3(EL3)andEL3-ProximalTransmembraneHelix7oftheMammalianTypeIandTypeIIGonadotropin-ReleasingHormone(GnRH)ReceptorsDetermin
...itytoGnRH-IbutnottoGnRH-II.Point-mutationstudiesindicatethatfouraminoacids,Leu/Phe7.38,Leu/Phe7.43,Ala/Pro7.46,andPro/Cys7.47inTMH7arecriticalforligandselectivityaswellasreceptorconformation.Furthermore,acombinatorymutation(Pro7.31-Pro7.32-Ser7.33motiftoSer-Glu-ProinEL3andLeu7.38,Leu7.43,Ala7.46,and...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第4期Novelrhodopsinmutationsandgenotype-phenotypecorrelationinpatientswithautosomaldominantretinitispigmentosa
...velmutations:Ser176Phe,Arg314fs16,andVal20Glyandtwomissensemutations,Pro215LeuandThr289Pro,thatwereonlyreportedonceinamutationreport.Electrophysiologicalandpsychophysicaltestingsprovideevidenceofanimpairedrodsystemwithadditionallyaffectedconesysteminsubjectsfromeachgenotypegroup.Visualfunctiontended...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第10期第二節 T淋巴細胞及其亞羣
...同屬於免疫球蛋白超家族。 胸腺白血病抗原(thymus-leukemiaantigen,TL或TLa)是一類同種異體抗原,僅表達於某些白血病和不成熟的Thy-1陽性胸腺細胞,爲早期分化抗原。TL抗原與小鼠H-2K、H-2D和H-2L抗原的結構相似。正常不成熟的...
醫源資料庫;醫源圖書館;教材類;細胞和分子免疫學Co-ingestionofproteinandleucinestimulatesmuscleproteinsynthesisratestothesameextentinyoungandelderlyleanmen
...roteinsynthesisratesoftheingestionofcarbohydratewithorwithoutproteinandfreeleucineaftersimulatedactivitiesofdailyliving.Design:Eightelderly(75±1y)and8young(20±1y)leanmenwererandomlyassignedto2crossoverexperimentsinwhichtheyconsumedeithercarbohydrate(CHO)orcarbohydrateplusproteinandfreeleuc...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年84卷第3期High-andlow-affinitytransportofL-leucineandL-DOPAbytheheteroaminoacidexchangersLAT1andLAT2inLLC-PK1renalcells
...minedthefunctionalcharacteristicsoftheinwardandoutwardL-[14C]DOPAandL-[14C]leucinetransportersinLLC-PK1cells.UptakewasinitiatedbytheadditionofHanks‘mediumwithagivenconcentrationofL-[14C]DOPAorL-[14C]leucine.Saturationexperimentswereperformedincellsincubatedfor6minwith0.25µMconcentrationofthe...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第8期鄰苯二甲醛柱前衍生反相高效液相色譜法測定水牛角中氨基酸的含量
...Met(蛋氨酸),Val(纈氨酸),Phe(苯丙氨酸),Ile(異亮氨酸),Leu(亮氨酸),Lys(賴氨酸)(均爲Sigma產品),實驗用水爲去離子重蒸水。流動相經過濾、脫氣處理。試樣溶液用0.45 μm濾膜過濾備用。2.2 色譜分析條件 Shim-packCLC-ODS,5 μ...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文TumorNecrosisFactorandEndothelin-1IncreaseP-GlycoproteinExpressionandTransportActivityattheBlood-BrainBarrier
...sforcytokines[e.g.,tumornecrosisfactor-(TNF-)(NadeauandRivest,1999)andinterleukin-1(IL-1)(Konsmanetal.,2004)]andinflammogens[e.g.,lipopolysaccharide(LPS)(ChakravartyandHerkenham,2005)].Theybothrespondtoinflammatorystimuliandamplifyinflammatorysignals(Nguyenetal.,2002;Rivest,2003).Thus,braincapillari...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期第十八章 蛋白質的生物合成--第一節 參與蛋白質生物合成的物質
...F絲(Ser)S酪(Tyr)Y半胱(Cys)CU苯內(Pne)絲(Ser)酪(Tyr)半胱(Cys)C亮(Leu)L絲(Ser)終止信號終止信號A亮(Leu)絲(Ser)終止信號色(Trp)GC亮(Leu)脯(Pro)P組(His)H精(Arg)RU亮(Leu)脯(Pro)組(His)精(Arg)C亮(Leu)脯(Pro)谷胺(Gin)Q精(Arg)A亮(Leu...
醫源資料庫;醫源圖書館;教材類;生物化學與分子生物學