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MatrixMetalloproteinase-2and-9DifferentiallyRegulateSmoothMuscleCellMigrationandCell-MediatedCollagenOrganization
...gelatinaseselectivecyclicpeptideinhibitorH-Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys-OH16(Bachem)onWTSMCattachmenttogelatin(50μg/well)wastestedatconcentrationsrangingfrom0.1to10μmol/L.PotentialrescueofMMP-9KOSMCattachmenttogelatin(50μg/well)wasdeterminedbyaddingpurifiedMMP-9.TodemonstratetheroleofC...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2004年第24卷第1期 -
Ras-DependentRecruitmentofc-MycforTranscriptionalActivationofNucleophosmin/B23inHighlyMalignantU1BladderCancerCells
...ationsignalsonthehumanimmunodeficiencyvirustype1RevproteinandthehumanT-cellleukemiavirus-1-Rexprotein,inbindingtocellcycle-regulatednucleolarproteinp120,andininhibitingDNA-bindingandtranscriptionalactivityofinterferonregulatoryfactor-1,whichisatumorsuppressor(Feuersteinetal.,1988;Boreretal.,1989;Fan...
醫源資料庫；在線期刊；分子藥理學雜誌；2006年第68卷第10期 -
補體C1抑制劑的研究進展
...gu、za等型的變異皆爲類似的變異，arg444分別被his、his、leu、ser、his替代[10~12]。當p1位的arg發生替代變異後，c1INH發生了靶酶識別異常，c1-抑制功能異常。 ocejo-Vinyals等[13]報道了一個Ⅱ型hAE變異的西班牙家族，在該家庭中發現...
合作平臺；醫學論文；基礎醫學論文；生物化學 -
P-SelectinGlycoproteinLigand-1IsExpressedonEndothelialCellsandMediatesMonocyteAdhesiontoActivatedEndothelium
...asnotaffectedbytreatingECswithinflammatorystimuli(tumornecrosisfactor,interleukin-1ß,thrombin,orhistamine).However,thefunctionalbindingcapacityofePSGL-1tomonocytesorP-selectin/FcchimerasignificantlyincreasedbystimulationoftheECswithTNF.BymeansofasiRNAapproachtospecificallyknock-downthegenesinv...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2007年第27卷第5期 -
High-dosevitamintherapystimulatesvariantenzymeswithdecreasedcoenzymebindingaffinity(increasedKm):relevancetogeneticdiseaseandpolymorphisms
...andiscardexcess.Viewthistable:TABLE2..Dietaryreferenceintakes(DRIs),tolerableupperintakelevels(ULs),andmega-dosesofnutrientsdiscussedinthisreviewTherapeuticremediationiscontingentonincreasingintracellularvitaminandcofactorconcentrations;therefore,wepresentsomedataonplasmaandtissueconcentrationsofcoe...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2002年75卷第4期 -
第二節 B細胞
...2細胞。在人也證明存在與小鼠相當的B細胞亞類，即CD5+（Leu-1+）B細胞（B1）和（CD5-（Lun-1+）B細胞（B2）二個亞類。 B1細胞羣和B2細胞羣無論在起源、表型和生物學特性等方面均有所不同。近年根據表型的不同可將B1細胞羣進...
醫源資料庫；醫源圖書館；教材類；醫學免疫學 -
AllelicVariantsoftheHumanScavengerReceptorClassBType1andParaoxonase1onCoronaryHeartDisease
...16to2.51).ThissignificantriskwasrestrictedtothosesubjectcarriersofArg(R)andLeu(L)alleleofthePON1192and55variantsandwasconfirmedinmultiplelogisticregressionanalysis.CLA-1/SR-BImRNAexpressionlevelsdifferedaccordingtoCLA-1/SR-BIgenotypes.Conclusions—Thesedatasuggestaplausiblegeneticinteractionbetween...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2005年第25卷第4期 -
ANovelNYMutationinConnexininKeratitis-Ichthyosis-DeafnessSyndrome
...nuousnegativevaluesofchemicalshiftdeviationsofCHintheN-terminalregion(Trp3-Leu10)suggestformationofhelicalconformationinbothwildtypeandmutant.Thus,thethree-dimensionalstructuralpropertiesofthesetwopeptidesarethoughttobebasicallythesame.Thisresultisfurtherconfirmedbythedatathatlargechangesinshiftbetw...
醫源資料庫；在線期刊；美國病理學雜誌；2006年第168卷第8期 -
Urokinase-TypePlasminogenActivator,anEndogenousAntibiotic
...onofuPAlevelselicitedbyendotoxin[19]andproinflammatorycytokines,suchasinterleukinIL-1andtumornecrosisfactor[2022],mayrepresentamechanismoftheinnateimmunesystemthatisareactiontoinfection.uPApotentiatesneutrophilactivation,includingsuperoxideproduction[23,24].IntheabsenceoftheuPAgene,neutrophilactivat...
醫源資料庫；在線期刊；傳染病學雜誌；2005年第191卷第15期 -
OutbreakofInfectionwithaMultiresistantKlebsiellapneumoniaeStrainAssociatedwithContaminatedRollBoardsinOperatingRooms
...rumbeta-lactamases(ESBL)inDutchhospitals.Infection27:348-354.Su,L.-H.,H.-S.Leu,Y.-P.Chiu,J.-H.Chia,A.-J.Kuo,C.-F.Sun,T.-Y.Lin,T.-L.Wu,andtheInfectionControlGroup.2000.Molecularinvestigationoftwoclustersofhospital-acquiredbacteraemiacausedbymulti-resistantKlebsiellapneumoniaeusingpulsed-fieldgelelect...
醫源資料庫；在線期刊；微生物臨牀雜誌；2005年第43卷第10期