糖基化終產物通過其受體誘導小鼠足細胞表達單核細胞趨化因子1
...孵育8h誘導足細胞產生MCP-1蛋白[分別爲(7.44±1.01,8.06±0.96)ng/L],明顯高於牛血清白蛋白(BSA)孵育的足細胞[(3.77±0.39)ng/L,均P<0.05],而孵育24hMCP-1的濃度分別爲(87.78±9.32,85.35±9.83和17.95±0.76)ng/L(均P<0.01)。(3)RAGE的另外一個配體,S1...
行業資訊;臨牀快報;藥理學MAPK途徑在大鼠肝幹細胞增殖調控中的作用
...導途徑之間的相互聯繫和作用機制。方法通過westernblotting檢測ERK、p38MAPK、Akt信號分子及磷酸化蛋白的表達;通過3H-TdR摻入DNA的方法來檢測細胞的增殖細胞。結果在WB細胞,HGF確實能夠激活ERK、p38MAPK、PI3K/AKT途徑。ERK途徑在HGF刺激...
醫源資料庫;在線期刊;中華醫學研究雜誌;2007年第7卷第5期sCD23在SLE患者血清中的檢測
...進行了比較。結果 ①病人組血清sCD23水平〔(4.10±3.16)ng/ml〕與正常對照組〔(1.48±0.41)ng/ml〕比較顯著增高(P<0.005),活動期水平明顯高於靜止期;②血清sCD23與ANA滴度、抗dsDNA抗體等具有明顯的平行關係;③皮損表皮少數(3/9)弱表...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學α-甲酰輔酶A消旋酶、核基質蛋白在前列腺癌早期診斷敏感性的比較
...α-methylacyl-CoAracemase,NMPinearlydiagnosisofprostatecancerLIUZhi-ming,LIZe-hui,LIZhi-peng.DepartmentofUrinaryandKidneySurgery,theSecondAffiliatedHospitalofKunmingMedicalCollege,Kunming650101,China[Abstract]ObjectiveTodetectα-methylacyl-CoAracemase(AMACR),nuclearmatrixpr...
醫源資料庫;在線期刊;中華現代臨牀醫學雜誌;2009年第7卷第2期MutationswithinSox2/SOX2areassociatedwithabnormalitiesinthehypothalamo-pituitary-gonadalaxisinmiceandhumans
...GeneticsUnit,InstituteofChildHealth,UniversityCollegeLondon,London,UnitedKingdom.3DivisionofDevelopmentalGenetics,MedicalResearchCouncilNationalInstituteforMedicalResearch,London,UnitedKingdom.4CancerResearchUK,SkinTumourLab,UniversityofLondon,London,UnitedKingdom.5CenterofPaediatricEndocrinology,De...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第9期Hepatocytegrowthfactorinducesanendothelin-mediateddeclineinglomerularfiltrationrate
...njury,andrepair.HGFalsoservesaprotectiveroleinchronicrenaldiseasebypreventingtissuefibrosis.Endothelin-1(ET-1),producedprimarilybyendothelialcells,isapotentvasoconstrictorthatalsoactsasaproinflammatorypeptide,promotingvascularinjuryandrenaldamage.Inadditiontomediatingavarietyofepithelialcellresponse...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第1期TNF-SuppressesProlyl-4-Hydroxylase1ExpressionviatheASK1-JNK-NonOPathway
...rnecrosisfactor-(TNF-),apivotalcytokinethatregulatesECMmetabolismbyincreasingdegradationanddecreasingproductionofarterialcollagens,isassociatedwithvulnerableplaquesandaorticaneurysms.MethodsandResults-Inthecurrentstudy,weshowedthat,whenadministeredindosesof1to100ng/mL,TNF-dose-dependentlydownregulat...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第8期銀屑病患者血清TNF-α、HA、LN濃度變化與細胞粘附分子的關係
...iesonTNF,HA,LNandleukocyteCD44relativityinthepsoriasisvulgarisLUONan-Ping SUNXiao-Ming YANGDao-Li (DepartmentofImmunology,GeneralHospitalofJinanMilitaryRegion,Jinan250031) Abstract Objective:Toexplorethecorrelationbetweenthetumornecrosisfactor-α(TNF-α),Hydluronicaoid(HA),...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學低鹽誘導的緻密斑細胞環氧化酶2表達與p38絲裂素激活蛋白激酶信號通路
...);PGE2分泌各時間點均顯著升高,於24h達高峯[(644.33±26.54)ng/L比(224.0±18.33)ng/L,P<0.01]。LS培養後,MMDD1細胞內p38MAPK的磷酸化程度顯著上調,180min時較高(從0.17±0.01升至0.28±0.01,P<0.01)。20μmol/Lp38抑制劑SB-203580下調LS誘導的COX-2蛋...
行業資訊;臨牀快報;腎臟相關ThePhenotypicDifferentiationofLocusCeruleusNoradrenergicNeuronsMediatedbyBrain-DerivedNeurotrophicFactorIsEnhancedbyCorticotropinReleasingFa
...yl-transferase.Althoughinactiveinitself,theneuropeptidecorticotropinreleasingfactor(CRF)stronglyamplifiedtheeffectofBDNF,increasingthenumberofcellsexpressingTHandtheactiveaccumulationofnoradrenalinebyafactorof2to3viaamechanismthatwasnonmitogenic.CRFalsoactedcooperativelywithneurotrophin-4,whichlikeB...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期