IdentificationofpoxvirusCD8+Tcelldeterminantstoenablerationaldesignandcharacterizationofsmallpoxvaccines
...niavirus;VARV,variolavirus.Inthelate1700s,EdwardJennerpublishedtheseminalobservationthatinfectionwithanimalpoxvirusesprotectshumansagainstsmallpox(1).Thoughsimilarpracticeshadbeenfollowedforcenturiesbyothersocietiesaroundtheworld,Jennerwasthefirsttoapplythescientificmethodtoevaluatingefficacy.Insodo...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第1期Effectofa28-dtreatmentwithL-796568,anovelß3-adrenergicreceptoragonist,onenergyexpenditureandbodycompositioninobesemen
...77;0.021and0.009±0.029,respectively).Nochangesinglucosetolerancewereobserved,buttriacylglycerolconcentrationsdecreasedsignificantlywithL-796568treatmentcomparedwithplacebo(-0.76±0.76and0.42±0.31mmol/L,respectively;P0.002).Overall,treatment-relatedchangesinbodycompositionwerenotobserve...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2002年76卷第4期CX3CR1DeficiencyConfersProtectionFromIntimalHyperplasiaAfterArterialInjury
...clecell(VSMC)proliferationandmigration.1-3Thesestereotypiccellularresponsesserveasthebasisformanyvasculardiseases,includingatherosclerosis,restenosis,andvasculitis.Themolecularmechanismsbywhichtheseresponsesareregulatedareoftremendousinterest.Bothanimalmodelsandhumangeneticassociationstudieshaveimpl...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第9期Dietaryintakeofn3andn6fattyacidsandtheriskofprostatecancer
...ispresentinsomevegetableoilsandnuts,leafyvegetables,andanimalfats(3).ALAcanserveinalimitedcapacityasaprecursorforeicosapentaenoicacid(EPA;20:5n3)anddocosahexaenoicacid(DHA;22:6n3)(4).TheconcentrationsofEPAandDHAarehighinfishoilsandtheyconsistentlyinhibittumorcellgrowthinanimalmodelsandin...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第1期OverexpressionoftheTranscriptionFactorGATA-EnhancestheDevelopmentofPulmonaryFibrosis
...aryfibrosis.2-4Itisinterestingthattheaccumulationoflymphocytesinthelungisobserved5to7daysafterbleomycinadministration,precedingthedevelopmentofpulmonaryfibrosis.5,6Amonglymphocytes,Tcellsarethemostlikelytoparticipateinthedevelopmentofbleomycin-inducedpulmonaryfibrosis.DepletionofTcellsbytreatmentwit...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第7期Alteredexpressionofselectedgenesinkidneyofratswithlithium-inducedNDI
...ntration,andincreasedurinarysodiumexcretion.Incontrast,nomajorchangeswereobservedintheexpressionofrenalsodiumtransportersinthethickascendinglimbs[e.g.,theNa-K-2ClcotransporterBSC-1,type3Na/Hexchanger(NHE3),andNa-K-ATPase],whereactiveNaClreabsorptionoccursasaconsequenceofcountercurrentmultiplication(...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第6期ADiet-InducedHypercholesterolemicMurineModeltoStudyAtherogenesisWithoutObesityandMetabolicSyndrome
...ides,andhousedincagesequippedwithrodentenrichments(iglooandgnawingbone;Bio-Serv,Frenchtown,NJ)inafacilitywitha12-hourlightcycle.Animalshadadlibitumaccesstowaterandfood.AllanimalexperimentswereperformedaccordingtoNIHguidelinesandwereapprovedbytheUniversityofCalifornia,SanDiegoAnimalSubjectsCommittee....
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第4期ObesityandCardiovascularDisease
...ionandbreathingworkload,respiratorymuscleinefficiency,decreasedfunctionalreservecapacityandexpiratoryreservevolume,andclosureofperipherallungunits.Theseoftenresultinaventilationperfusionmismatch,especiallyinthesupineposition.Obesityisaclassicalcauseofalveolarhypoventilation.Numeroustreatmentsareavai...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第5期RetinoblastomaPathwayDysregulationCausesDNAMethyltransferaseOverexpressioninCancerviaMAD-MediatedInhibitionoftheAnaphase-PromotingComplex
...ysignificant,correlationbetweenMAD2andDNMT1immunohistochemicalstainingwasobserved,yieldingaSpearmanrankordercorrelationcoefficientof0.37(P<0.001).ThissuggeststhatRBpathwayinactivation,acommondysfunctionincancercells,maybetheunderlyingcauseofDNMT1dysregulation.----------------------------------------...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第5期Osteoporosis:theroleofmicronutrients
...wellasthepreventionoffallsandfractures.Inaddition,ahealthydietthatincludes5servingsadayoffruitsandvegetablesshouldoptimizetheintakeofmicronutrientsrequiredforbonehealth.KeyWords:CalciumvitaminDfallsfracturesosteoporosismicronutrientsINTRODUCTIONThemostrecentdefinitionof...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年81卷第5期