Methyl2-Cyano-3,11-dioxo-18β-olean-1,12-dien-30-oateIsaPeroxisomeProliferator-ActivatedReceptor-AgonistThatInducesReceptor-IndependentApoptosisin
...fectedbykinaseinhibitors.CDDOandrelatedcompoundsalsoinduceactivationofJNKinleukemiacellsthroughincreasedreactiveoxygenspecies(Ikedaetal.,2003),andFig.4Eillustratestheeffectsofβ-CDODA-MeonactivationofJNKandATF3aftercotreatmentwiththeantioxidantNAC.InductionofJNKphosphorylationandATF3byβ-CDO...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第2期AssociationofTumorNecrosisFactor-PolymorphismsandOzone-inducedChangeinLungFunction
...artate299glycine(Asp299Gly),SOD2valine16alanine(Val16Ala),andGPX1proline197leucine(Pro197Leu)polymorphisms.GenotypingoftheTNFgenewasextendedacrossthepromoterregionandintotheadjacentLTAgene,becauseofthepositiveassociationfoundwiththeTNFeC308GApolymorphism.PolymerasechainreactioneCbasedmethodswereused...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第1期IP-10BlocksVascularEndothelialGrowthFactor-InducedEndothelialCellMotilityandTubeFormationviaInhibitionofCalpain
...kedwhetherthesamesignalsstoppedangiogenicingrowth.TwooftheELR(glutamicacid-leucine-arginine)-negativeCXCchemokinesappearlateintheregenerativephase.IP-10(interferoneCinducibleprotein10,CXCL10)isproducedbyendothelialcellsthemselveslateintheregenerativephase3andIP-9(I-TAC,CXCL11)derivesfromredifferenti...
醫源資料庫;在線期刊;循環研究雜誌;2006年第96卷第3期Derlin-1andp97/Valosin-ContainingProteinMediatetheEndoplasmicReticulum-AssociatedDegradationofHumanV2VasopressinReceptors
...erecomputed.L62PandV226Ewerediffuselylocalizedwithinthecell,excludingthenucleus(Fig.2,left).LysoTrackerRedsignalsweredetectedasintracellularvesicles,frequentlynearbythenucleus(Fig.2,middle)andnocolocalizationwithGFPsignalscouldbeidentifiedinoverlaysofmutantsL62PandV226E(Fig.2,right).MutantG201Dwasde...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期Geneexpressionof5-,12-,and15-lipoxygenasesandleukotrienereceptorsalongtheratnephron
...cyclooxygenases,EETs,andHETEsformedbycytochromeP-450(CYP)enzymesandHETEsandleukotrienesgeneratedbylipoxygenases.WhereastheintrarenallocalizationofcyclooxygenasesandofsomeCYPenzymesalongthenephronhasalreadybeendetermined,thelocalizationoflipoxygenasesandleukotriene-formingenzymestogetherwithleukotrie...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第4期EffectsofUnfractionatedHeparinandGlycoproteinIIb/IIIaAntagonistsVersusBivalirdinonMyeloperoxidaseReleaseFromNeutrophils
...randomizedtoreceiveadjunctivetherapywithbivalirudinorUFH+eptifibatide.Interleukin(IL)-6andC-reactiveprotein(CRP)transientlyincreasedinbothgroupsafterPCI.IntheUFH+eptifibatide,butnotthebivalirudingroup,myeloperoxidase(MPO)levelswereelevated2.3-foldabovebaseline(P=0.004)immediatelyafterPCI.Inaninvitro...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第8期EvaluationofAngiogenesisandVascularEndothelialGrowthFactorExpressionintheBoneMarrowofPatientswithAplasticAnemia
...antroleinhematopoieticneoplasms.17-24Thus,inmostBMneoplasmsincludingmyeloidleukemiasandmyelodysplasticsyndromes,anenhancedBMangiogenesishasbeendescribed.17-20,23,24Toacertaindegree,thesamemayholdtrueforreactivediseasestates(systemicinflammation,chronicinfection)inwhichenhancedBMfunction,ie,growthofp...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第1期綠色熒光蛋白與H-2Kb融合基因的構建及表達
...150mmol/LNaCl,1%CHAPS(Pierce),100μg/μlPMSF,1μg/μlaprotinin,1μg/μlleupeptin(Calbiochem)。冰浴30min後,將裂解物以12000×g離心5min,收集上清。在12%SDS-PAGE上進行分離後,電轉移至硝酸纖維薄膜上。5%BSA封閉30min後,將薄膜與兔抗GFP多抗(Clonetech...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學N-TerminalResiduesControlProteasomalDegradationofRGS2,RGS4,andRGS5inHumanEmbryonicKidney293Cells
...etheywouldbepredictedtoincreaseproteasomaldegradationbytheN-endrulepathway(LeuandArgareconsideredprimarydestabilizingresidues)(Varshavsky,1996).Thus,inthepresentstudy,weinvestigatethefunctionandexpressionofmembersoftheR4subfamilyofRGSproteins.Inparticular,weasked:DoRGS2,-3,-4,-5,and-8proteinsexhibit...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第4期DeterminationofBindingSiteResiduesResponsiblefortheSubunitSelectivityofNovelMarine-DerivedCompoundsonKainateReceptors
...radioligandbindingandelectrophysiologicalassays.Threecandidatesites,Val685,Leu735,andSer741inGluR5,correspondingtoIle669,Phe719,andMet725inKA2,werepredictedtounderliethedistinctbindingprofilesofthemarinetoxins.Singleormultiplereciprocalmutationsintroducedintothereceptorsubunitsproducedavarietyofeffe...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期