第五節 膽固醇調節元件結合蛋白
...有“鹼性螺旋-環-螺旋-亮氨酸拉鍊”(basichelix-loop-helix-leucinezipper,bHLH-ZIP)結構,是bHLH-ZIP蛋白系列的一種。bHLH-ZIP蛋白包含一系列能特異性地和含E盒(ebox,CANNTG)的DNA結合的蛋白質,例如:調節免疫球蛋白基因翻譯的TFE3,致腫...
醫源資料庫;醫源圖書館;教材類;動脈粥樣硬化Schoenheimereffectexplained–feedbackregulationofcholesterolsynthesisinmicemediatedbyInsigproteins
...1actsinliverwhenitisoverexpressed,buttheydidnotindicatewhetherInsigsplayaroleundernormalconditions.Inthecurrentpaper,wehaveaddressedthesequestionsbydisruptingthegenesforInsig1andInsig2,togetherorseparately,inliversofmice.TheresultsindicatethatInsigsareessentialcomponentsofthecholesterol-feedbacksyst...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第9期AlternativeTranslationInitiationofHumanRegulatorsofG-ProteinSignaling-2YieldsaSetofFunctionallyDistinctProteins
...romORFs1to4showednodifferenceinGqinhibitorypotentialorrecruitmentfromthenucleusinresponsetoGqsignaling.Bycontrast,RGS2productsinitiatingfrommethioninesatpositions16(ORF3)and33(ORF4)wereimpairedasinhibitorsoftypeVadenylylcyclase(ACV)comparedwithfull-lengthRGS2.WepredictedthatregulationoftheRGS2expres...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第1期雷帕黴素抑制血管緊張素Ⅱ誘導的血管內皮細胞增生
...frapamycin.Thecellproliferationwasmeasuredby3H-thymidineincorporationand3H-leucinneincor-poration.Cellcyclewereanalysedbyflowcytometry.Expressionofp70S6k,ERK2,cyclinA,cyclinB1andcyclinD1weredetectedbyWesternblots.ResultsRapamycininhibitedAngⅡ-inducedincreaseinproteincontentandDNAsynthesiswit...
合作平臺;在線期刊;中華醫學研究雜誌;2005年第5卷第5期;論著Mitochondria,Calcium,andCalpainareKeyMediatorsofResveratrol-InducedApoptosisinBreastCancer
...o-Guisadoetal.,2005).Asanticipated,activationofcaspase-9and-3wasnotdetectableuponREStreatmentofMCF-7cells.Alternatively,extrinsicdeathreceptormediatedapoptosisproceedingthroughtheactivationofinitiatorcaspases-2and-8hasbeenelicitedbyRES(Delmasetal.,2003;Mohanetal.,2006).However,theabsenceofcaspase-2a...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第12期第二十二章 癌基因與抑癌基因
...GlyGGC Val GTC Arg CGCGlyAla ThrGlnCAG Leu CTGK-ras-2來源的 正常人c-K-ras-2 人Caalu肺癌 人SW480結腸癌 鼠Kirsten病毒v-K-rasGlyLys TGT Val GTT SerGlyAla ThrGlnN-ras來源的 正常人N-r...
醫源資料庫;醫源圖書館;教材類;生物化學與分子生物學AssociationofTransformingGrowthFactor-ß1GenePolymorphismsWithMyocardialInfarctioninPatientsWithAngiographicallyProvenCoronaryHeartDisea
...etranslatedsequenceofTGFB1andgiverisetoaminoacidsubstitutionsatpositions10(Leu10Pro)and25(Arg25Pro)inthesignalpeptideofTGF-ß1,respectively.16,17The868T/CSNPwasreportedtoinfluencesteady-stateconcentrationsofTGFB1mRNAinperipheralbloodmononuclearcellsandserumlevelsofTGF-ß1,andthe913G/CSNPwa...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第5期PosttranslationallyModifiedProteinsasMediatorsofSustainedIntestinalInflammation
...ogicallydetectableinflammationinwild-typemice,butnotinRAGEC/Cmice.Acomparableup-regulationofNF-BandinflammationonrectalapplicationofCML-mpswasobservedinIL-10C/Cmice.Thus,CML-mpsgeneratedininflammatorylesionshavethecapacitytoelicitaRAGE-dependentintestinalinflammatoryresponse.------------------------...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第10期Real-timeimagingofreninreleaseinvitro
...DABCYL-conjugatedfluorescentreninsubstrate(DABCYL--Abu-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr,AnaSpec,SanJose,CA)wasaddedtothebathingsolution(2µM).Intheabsenceofreninactivity,EDANSfluorescenceisquenchedbytheacceptormoleculeDABCYLduetofluorescenceresonanceenergytransfer(FRET).However,whencleav...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第8期ATP-sensitivepotassiumchannelopathies:focusoninsulinsecretion
...euronstheymediatethecounter-regulatoryresponsetoglucose(11),andinarcuatenucleusneuronstheymaybeinvolvedinappetiteregulation(12).Intheseglucose-sensingcells,KATPchannelsrespondtofluctuatingchangesinbloodglucoseconcentration.Inmanyothertissues,however,theyarelargelyclosedunderrestingconditionsandopeno...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第8期