垂體腺苷酸環化酶激活肽及其生物學效應
...-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala -Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2,PACAP27具有PACAP38氨基末端(N端)1~27位aa序列;二者均具有酰胺化羧基末端;PACAP38的N端1~28位aa與血管活性腸肽(vasoactivei...
合作平臺;醫學論文;基礎醫學論文;細胞及分子生物學NeuropathologyinRhinosinusitis
...ureaasamarker.JAllergyClinImmunol1993;92:457eC465.BaraniukJN,NaranchK,AliM,LeU.Pathophysiologyofrhinosinusitis:baselinesymptomsandsecretionsinacutesinusitis(S),allergicrhinitis(AR),thenonallergicrhinitisofchronicfatiguesyndrome(CFS)andnormalsubjects.AmJRespirCritCareMed2004;169:A820.vanCauwenbergePB...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第1期Platelet-LeukocyteInteractionandPlateletActivationinAcuteStrokeWithandWithoutPrecedingInfection
...eletactivation.Incoronarysyndromes,theimportanceofinflammationwithplatelet-leukocyteinteractionhasbeendemonstrated.Recentinfectionisanestablishedriskfactorforischemicstroke;theroleofplatelet-leukocyteinteractioninthesepatientshadnotbeeninvestigated.MethodsandResults—Usingaflowcytometricassayweinve...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第7期蛋白復性(四)-淺談蛋白質摺疊的有關問題
...現,Hy-(W/X)-Hy-X-Hy-X-Hymotif與Bipj結合最強,Hy最多的是Trp、Leu、Phe,即較大的疏水殘基。一般來說,2-4個疏水殘基就足夠進行結合。還有一種較普遍的說法是分子伴侶識別所謂熔球體結構(moltenglobule)。另一方面,分子伴侶本身與...
醫藥經濟;生物技術;實驗技術;生化與分子技術NovelGenomicLociInfluencingPlasmaHomocysteineLevels
...fthecarotidarteryareassociatedwithhyperhomocysteinemiaandplateletantigen-1(Leu33Pro)polymorphism.Stroke.2001;32:2753–2758.BostomAG,RosenbergIH,SilbershatzH,JacquesPF,SelhubJ,D’AgostinoRB,WilsonPW,WolfPA.Nonfastingplasmatotalhomocysteinelevelsandstrokeincidenceinelderlypersons:TheFraminghamstudy....
醫源資料庫;在線期刊;中風學雜誌;2006年第37卷第7期DualEffectofAngiotensin-ConvertingEnzymeInhibitiononAngiogenesisinType1DiabeticMice
...nespontaneouslyhypertensiverats.Hypertension.1997;29:478–482.HuDE,FanTPD.Leu8desArg9-bradykinininhibitstheangiogeniceffectofbradykininandinterleukin-1inrats.BrJPharmacol.1993;109:14–17.PorcuP,EmanueliC,KapatsorisM,ChaoJ,ChaoL,MadedduP.Reversalofangiogenicgrowthfactorupregulationbyrevascularizati...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第1期JointLinkageandAssociationofSixSingle-NucleotidePolymorphismsintheFactorXIII-ASubunitGenePointtoV34LAstheMainFunctionalLocus
...radoxically,astepwiseincreaseinFXIIIactivationwithpossessionoftheprotectiveLeuallelehasbeenfound,withnodifferencesinFXIII-AandB-subunitlevels.8,9Invitrostudieshaveshownthat34LiscleavedfasterbythrombinthantheValvariant,10withanincreaseinproteolyticefficiencyby2-to3-fold.10,11Howthisrelatestotheriskof...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第8期RoofandFlooroftheMuscarinicBindingPocket:VariationsintheBindingModesofOrthostericLigands
...ledbydivisionbythesumofthecorrespondingvaluestakenoverthefollowingresidues:Leu102,Tyr106,Ser109,Trp157,Trp378,Tyr381,Asn382,Tyr404,andCys407;thus,fortheithresiduethevaluesplottedwerepKdi/pKd,Leu102,Tyr106...Cys407andEi/ELeu102,Tyr106....Cys407.TheselectiveimportanceofPhe197forthebindingofNMSisreprod...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第12期ANovelLossofFunctionMutationofPCSK9GeneinWhiteSubjectsWithLow-PlasmaLow-DensityLipoproteinCholesterol
...ndanovelPCSK9mutationinexon1(c.202delG)resultinginatruncatedpeptide(Ala68fsLeu82X).Twofamilialhypobetalipoproteinemiasubjectsand4hypocholesterolemicblooddonorswerecarriersoftheR46Lsubstitutionpreviouslyreportedtobeassociatedwithreducedlow-densitylipoproteincholesterolaswellasotherrareaminoacidchange...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第3期ExtensiveAssociationAnalysisBetweenPolymorphismsofPONGeneClusterWithCoronaryHeartDiseaseinChineseHanPopulation
...ctionsatthecellularlevel.ThePON1-codingregioncontains2commonpolymorphisms,aleucine(L)tomethionine(M)substitutionatcodon55andaglutamine(Q)toarginine(R)substitutionatcodon192.TheQ192RpolymorphismseemstobethemajordeterminantofserumPON1activitytowardvariousorganophosphates7andhasbeenreportedtoaffectthee...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2003年第23卷第2期