TheRoleofThr139intheHumanImmunodeficiencyVirusType1ReverseTranscriptaseSensitivityto(+)-CalanolideA
...ractThecoumarinsrepresentauniqueclassofnon-nucleosidereversetranscriptaseinhibitors(NNRTIs)thatwereisolatedfromtropicalplants.(+)-CalanolideA,themostpotentcompoundofthisclass,selectsfortheT139IresistancemutationinHIV-1reversetranscriptase(RT).SevenRTsmutatedataminoacidposition139(Ala,Lys,Tyr,Asp,Ile...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第3期Objectiveperimetryusingthemultifocalvisualevokedpotentialincentralvisualpathwaylesions
...VEP)todetectfieldlossinneurologicallesionsaffectingthevisualpathwayfromthechiasmtothecortex.Method:ThemVEPsrecordedintheclinicwereretrospectivelyreviewedforanycasesinvolvingcentralneurologicallesions.RecordingshadbeenperformedwiththeAccuMapV1.3objectiveperimeter,whichusedanarrayoffourbipolaroccipita...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第6期Dietaryglycemicload,addedsugars,andcarbohydratesasriskfactorsforpancreaticcancer:theMultiethnicCohortStudy
...ceNKolonel1FromtheCancerResearchCenterofHawaii,UniversityofHawaii,Honolulu,HI(UN,SPM,LRW,andLNK);theUniversityofSouthernCalifornia,LosAngeles,CA(BEH);andtheGermanInstituteofHumanNutritionPotsdam-Rehbruecke,Nuthetal,Germany(UN)2Thecontentsofthisreportaresolelytheresponsibilityoftheauthorsanddonotnece...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年86卷第5期GenotypeandPlasmaConcentrationofCystatinCinPatientsWithCoronaryHeartDiseaseandRiskforSecondaryCardiovascularEvents
...ng.koenig@medizin.uni-ulm.deAbstractObjective—CysteineproteasesandtheirinhibitorssuchascystatinCareassumedtoplayanimportantroleinthepathogenesisofatherosclerosisandcoronaryheartdisease(CHD).TheaimofthestudywastoinvestigatetheimpactofcystatinCpolymorphismsoncystatinCplasmalevelsandonprognosisofpati...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第7期中老年結直腸腺瘤癌變細胞免疫組化及增殖活性研究
...瘤P53蛋白β-catenin增殖細胞核抗原免疫組織化學StudyofimmunohistochemistryandcellulerproliferationactivityoncarcinogenesisofcolorectaladenomawithmalignanttransformationZHANGPin-nan,LUHe-lian,WANGZhong-quan,etal.WenzhouThirdPeple’sHospital,WenzhouZhejiang325000,China【Abstract】...
醫源資料庫;在線期刊;中華醫學研究雜誌;2007年第7卷第10期Infectedsite-restrictedFoxp3+naturalregulatoryTcellsarespecificformicrobialantigens
...tesofHealth(NIH),Bethesda,MD208922DivisionofMolecularImmunology,CincinnatiChildren‘sHospitalResearchFoundation,Cincinnati,OH452293DepartmentofMicrobiology,DepartmentofImmunology,andCenterfortheStudyofHostResistance,McGillUniversity,Montreal,QuebecH3A2BA,CanadaNaturalregulatoryT(Treg)cellsareinvolv...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第3期免疫超家族的新成員-CD200分子研究近況
...的紅髓中,用F4/80染色法在大面積區域裏觀察到F4/8010-GRIhi粒細胞和F4/80hi-Ghko成熟的巨噬細胞區顯著擴大,CD11b+在數目上是正常鼠的2倍。而CD11b+是DC1的表面標誌物,說明CD200有抑制DC0向DC1分化的作用,從而在一定程度上促進Th0向Th2...
合作平臺;在線期刊;中華醫學研究雜誌;2004年第4卷第7期;論著E47isrequiredforV(D)Jrecombinaseactivityincommonlymphoidprogenitors
...er,MA01655Commonlymphoidprogenitors(CLPs)arethefirstbonemarrowprecursorsinwhichV(D)Jrecombinaseactivityisup-regulated.Here,weshowthatlossofthetranscriptionfactorE47producesareducedCLPpopulationthatlacksV(D)JrecombinaseactivityandD-JHrearrangementsinvivo.Apartfromaprofoundarrestbeforethepro–Bcellst...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第12期哈薩克族人羣DNA損傷修復基因hOGG1多態性研究*
...GG1多態性哈薩克族人羣腫瘤易感性ThepriminarystudyonthepolymorphismofDNArepairgenehOGG1inhazakhpopulationWUYuan-liang,KEYue-bin,LILong,etal.PublicHealthCollege,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology.Wuhan430030,China【Abstract】OjbectiveTostudythepolymorphismdist...
醫源資料庫;在線期刊;中華醫學研究雜誌;2008年第8卷第4期DetectionofRecurrencesUsingUnenhancedandContrast-EnhancedTranscranialColor-CodedDuplexSonography
...ommon,surveillancetoassesslong-termstabilityofocclusionisclearlyimportant.Thisstudyevaluatedunenhancedandcontrast-enhancedtranscranialcolor-codedduplexsonography(TCCS)indetectingrefillingofIAstreatedwithdetachablecoils.Methods—PatientswithcoiledIAswereimagedbeforeandaftercontrastenhancement.Theres...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第12期