IKK/NF-Bsignaling:balancinglifeanddeath–anewapproachtocancertherapy
...logyandCancerCenter,SchoolofMedicine,UCSD,LaJolla,California,USA.AbstractIBkinase/NF-B(IKK/NF-B)signalingpathwaysplaycriticalrolesinavarietyofphysiologicalandpathologicalprocesses.OnefunctionofNF-Bispromotionofcellsurvivalthroughinductionoftargetgenes,whoseproductsinhibitcomponentsoftheapoptoticmach...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期FirstCaseofHumanCryptococcosisDuetoCryptococcusneoformansvar.gattiiinSpain
...canavaninaglycinebromothimolblueagargrowth,serotypedetermination(Cryptochecktest;Iatron),andgenotypeanalysisrevealedthatthestrainwasC.neoformansvar.gattiserotypeB.Thestrainidentificationandserotypewereconfirmedinanothermycologylaboratory(IMIM,Barcelona,Spain).Twoantifungaldrugsensitivitytestswereper...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期CD44isaphysiologicalE-selectinligandonneutrophils
...rtmentofMedicineandCenterforImmunobiology,MountSinaiSchoolofMedicine,NewYork,NY10029Theselectinfamilyofadhesionmoleculesandtheirglycoconjugatedligandsareessentialforbloodpolymorphonuclearneutrophil(PMN)extravasationintoinflammatoryandinfectioussites.However,E-selectinligandsonPMNsarenotwellcharacter...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第8期ComparisonofanInternallyControlled,Large-VolumeLightCyclerAssayforDetectionofMycobacteriumtuberculosisinClinicalSampleswiththeCOBASAMPLICOR
LaborBecker,OlgemllerundKollegen,MünchenInstitutfürMedizinischeMikrobiologieundHygiene,UniversityofRegensburgBayerischesLandesamtfürGesundheitundLebensmittelsicherheit,Oberschleiheim,GermanyABSTRACTWepresentasensitiveandspecificassayforreliableandflexibledetectionofmembersoftheMycobacteriumtuberc...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期高原腦水腫68例高原現場治療臨牀分析
...卡託普利或鈣離子阻滯劑,以緩解支氣管痙攣,降低肺動脈壓,有心腎功能不全者適當給予強心利尿,並可給多巴胺20~40mg/d,靜滴。有感染者給予足量抗生素,並注意及時糾正水、電解質和酸鹼平衡紊亂。2結果 經綜合治療(4...
醫源資料庫;在線期刊;中華醫學研究雜誌;2009年第9卷第1期第五課 抗體藥物的製造途徑
...陷,一個是它們是分子蛋白質,這就是說,它們必須經靜脈注射而不是片狀口服,所以,它們不能經咀嚼後進入消化系統——雖然研究人員希望很快解決這個問題,(相反一面的意見是它們最終在人體中存在相當長,這就意味着...
醫源資料庫;醫源圖書館;教材類;抗體藥物的重新崛起SelectivegenerationoffunctionalsomaticallymutatedIgM+CD27+,butnotIgisotype-switched,memoryBcellsinX-linkedlymphoproliferativedisease
...alofPhiladelphia,Philadelphia,Pennsylvania,USA.AbstractIndividualswithX-linkedlymphoproliferativedisease(XLP)displaydefectsinBcelldifferentiationinvivo.Specifically,XLPpatientsdonotgenerateanormalnumberofCD27+memoryBcells,andthosefewthatarepresentareIgM+.RecentstudieshavesuggestedthatIgM+CD27+Bcells...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期腹膜透析治療1例尿毒症合併上消化道出血的護理
...樣便,量大,共計2000ml,BP80/40mmHg,伴神志不清,給予靜脈輸血400ml補充血容量,輸入洛賽克、止血敏止血治療。鼻飼凝血酶、去甲腎上腺素、達喜、三七、白及等藥物止血治療後,上消化道出血控制,便潛血陰性,搶救成功。2...
醫源資料庫;在線期刊;中華中西醫雜誌;2007年第8卷第6期Blood-brainbarrierinvasionbygroupBStreptococcusdependsuponpropercell-surfaceanchoringoflipoteichoicacid
...icrovascularendothelialcells(BMECs)exhibitingcontinuoustightjunctionsandlackingpinocytosis(2).PenetrationoftheBBBbyabacterialpathogenreflectsacomplexinterplaybetweenthehostendotheliumandmicrobialsurfacecomponents.TheGram-positivebacteriumStreptococcusagalactiae,knownasgroupBStreptococcus(GBS),isthel...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第9期Geneticessentialtremorin-aminobutyricacidAreceptor1subunitknockoutmice
...lvania,USA.AbstractEssentialtremoristhemostcommonmovementdisorderandhasanunknownetiology.Herewereportthat-aminobutyricacidA(GABAA)receptor1–/–miceexhibitposturalandkinetictremorandmotorincoordinationthatischaracteristicofessentialtremordisease.Wetestedmicewithessential-liketremorusingcurrentdrug...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期