MouseStrain–SpecificDifferencesinVascularWallGeneExpressionandTheirRelationshiptoVascularDisease
...sandlivertriglcyceridecontent,isassociatedwithimprovedinsulinsensitivity.25Hmgcs2(3-hydroxy-3-methylglutaryl[HMG]CoAsynthase)wasnotedtohavelowerexpressioninC3Hmiceaswell.Thisenzymecondensesacetyl-CoAwithacetoacetyl-CoAtoformHMG-CoA,whichisthesubstrateforHMG-CoAreductase.HMG-CoAreductaseinhibitorsare...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第2期Sphingosine-1-PhosphateAnalogueFTY720CausesLymphocyteRedistributionandHypercholesterolemiainApoE-DeficientMice
...ncreaseinserumcholesterol(largelyVLDLfraction)anda1.8-foldincreaseinhepaticHMGCoAreductasemRNA.FTY720increasedplasmasphingosine-1-phosphateandinducedmarkedperipheralbloodlymphopenia.AdiscoordinatemodulationofB,Tandmonocytecellnumberswasfoundinperipherallymphoidorgans.OveralldepletionofTcellswasaccom...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第11期IncreaseofCirculatingEndothelialProgenitorCellsinPatientswithCoronaryArteryDiseaseAfterExercise-InducedIschemia
...maximumofdifferentiatedadherentEPCsafter48hoursofincubatingisolatedMNCwithaHMG-CoAreductaseinhibitor(atorvastatin).20Intheclinicalcontext,GilletalreportedasignificanttransientincreaseofEPCs6to12hoursafteravasculartrauma(coronaryarterybypasssurgeryorburninjury).21Sofar,onlycross-sectionaldatahavebeen...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第4期體外受精胚胎移植治療原發性不孕症療效分析
...第3d開始,採用促卵泡素(FSH)、人絕經尿促性腺激素(HMG)/人絨毛膜促性腺激素(HCG)方案促超排卵。期間通過B超監測卵泡發育情況,當主導卵泡直徑達18mm,並有3個卵泡直徑≥15mm時,肌注HCG5000~10000IU,34~36h後B超引導下...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2008年第8卷第6期超聲檢查在梗阻性難產中的作用
...機率高,近年來有醫源性原因,應用氯米酚與尿促性素(HMG)誘發排卵,雙胎與多胎妊娠可高達20%~40%。另有學者報道在停止使用避孕藥後1個月妊娠時,雙胎比例增高,是由於此月分泌卵泡刺激素(FSH)增高之故。超聲檢查對...
醫源資料庫;在線期刊;中華現代影像學雜誌;2006年第3卷第9期Rac1RegulationofSurfaceExpressionofProtease-ActivatedReceptor-1andResponsivenesstoThrombininVascularSmoothMuscleCells
...ceinvascularsmoothmusclecells.Wefirstusedhydroxy-3-methylglutarylcoenzymeA(HMG-CoA)reductaseinhibitors(statins)toinhibittheproteinisoprenylationsuchasgeranylgeranylationandfarnesylation,whichisessentialforsmallG-proteinstobefunctional.16,23–25Second,weintroducedtheinhibitoryproteinsofRhoproteinsus...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第7期薯蕷皁苷類化合物體外抗腫瘤作用的研究
...科百合屬LiliumspeciosumX.Lnobiissium中分離得到的27CH2OHMGMe薯蕷皁苷元3OαL鼠李吡喃糖基(1→2)O[βD葡萄吡喃糖基(1→4)]OβD葡萄吡喃糖苷在5μg/ml濃度下抑制活性爲40.3%,是laxogenin活性...
醫源資料庫;在線期刊;濱州醫學院學報;2008年第31卷第5期茚地那韋的藥理及臨牀應用
...伐他汀或洛伐他汀合用。本品與其它通過CY3A4途徑代謝的HMG—CoA還原酶抑制劑合用時,會增加肌病(包括橫紋肌溶解)的危險性。本品不宜與聖約翰草或含有聖約翰草的藥品合用,本品與StJohn’s草合用時,會降低硫酸茚地那韋濃...
合作平臺;在線期刊;中華實用醫藥雜誌;2004年第4卷第14期;其他FluvastatinPreventsVascularHyperplasiabyInhibitingPhenotypeModulationandProliferationThroughExtracellularSignal-RegulatedKinase1and2andp38M
...rophy?phenotypicmodulationIntroduction3-Hydroxy-3-methyl-glutarylcoenzymeA(HMG-CoA)reductaseinhibitors,statins,aredrugsthatdecreasetheplasmalipidconcentrationbyinhibitingHMG-CoAreductase,arate-limitingenzymeforthecholesterolbiosynthesis,inhepaticcells.1Inaddition,theirabilitytoreducecholesterolsynth...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第2期糖基化終產物對小鼠腹腔巨噬細胞活化與MMP-9活性的影響以及辛伐他汀的作用
...戊酸途徑。他汀類藥物是多種3-羥基-3-甲基戊二酰輔酶A(HMG-CoA)還原酶抑制劑的總稱,其降脂作用肯定。越來越多的證據顯示,除降脂作用外,他汀類藥物可阻止斑塊形成和進展、抗血栓形成、促進缺血心肌血管新生、改善內皮細...
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