Inductionofintrahepaticcholangiocellularcarcinomabyliver-specificdisruptionofSmad4andPteninmice
...sociatedwithsignificantalterations,includingincreasedlevelsofphosphorylatedAKT,FOXO1,GSK-3?,mTOR,andERKandincreasednuclearlevelsofcyclinD1.WefurtherdemonstratethatSMAD4andPTENregulateeachotherthroughanovelfeedbackmechanismtomaintainanexpressionbalanceandsynergisticallyrepressCCformation.Finally,oura...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第7期ClinicalApplicationsofStemCellsfortheHeart
...herapytrials,stop-flowcelldeliverywasperformedseveraldaysafterreperfusion,makingpostconditioninganunlikelyexplanationfortheeffectsofcelltherapy.Nevertheless,futuretrialsneedtoincludecontrolgroupsthatundergobonemarrowharvestandanintracoronaryshaminfusiontounambiguouslyestablishthatcelltransfer,andnot...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第2期AllelicdilutionobscuresdetectionofabiologicallysignificantresistancemutationinEGFR-amplifiedlungcancer
...fEGFRT790MeffectivelyconferredresistancetogefitinibandcontinuedErbB-3/PI3K/Aktsignalingwhenincistoanactivatingmutation.Moreover,continuedactivationofPI3KsignalingbythePIK3CAoncogenicmutant,p110E545K,wassufficienttoabrogategefitinib-inducedapoptosis.Thesefindingssuggestthatallelicdilutionofbiological...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第10期Melanomageneticsandthedevelopmentofrationaltherapeutics
...)(Figure2).GermlineCDKN2Amutationswereidentifiedin25–50%offamilialmelanomakindreds(40-42).TheimportanceofthislocusinmelanomasusceptibilitywasconfirmedbystudiesshowingthatthepenetranceofCDKN2Amutationssignificantlycorrelatedwithresidenceinageographicallocationwithahighpopulationincidencerateofmelan...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第4期第七章 診斷酶學--第一節 概述
...CPK)3.1.1.3脂肪酶LPS3.1.1.8膽鹼酯酶CHE3.1.3.1鹼性磷酸酶ALP(AKP)3.1.3.2酸性磷酸酶ACP3.2.1.1α-澱粉酶AMY(AMS)3.4.11.2氨基酸芳香酰胺酶LAP4.1.2.13果糖二磷酸醛縮酶ALD2.1.3.3鳥氨酸氨甲酰基轉移酶OCT3.1.3.55′-核苷酸酶5′-NA(5′-NT) *EC...
醫源資料庫;醫源圖書館;教材類;臨牀生物化學Bcl-2–relatedproteinA1isanendogenousandcytokine-stimulatedmediatorofcytoprotectioninhyperoxicacutelunginjury
...andactivationofintrinsicandmitochondrial-deathpathways,andalveolarproteinleak.Bcl-2andBcl-xlwerealsoinducedasanapparentprotectiveresponse.A1wasinducedinhyperoxia,andinA1-nullmice,thetoxiceffectsofhyperoxiawereexaggerated,Bcl-2andBcl-xlwerenotinduced,andprematuredeathwasseen.Incontrast,IL-11stimulate...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第4期PathogenicRoleforVirus-SpecificCDTCellsinMicewithCoronavirus-InducedAcuteEncephalitis
....IA.DonorRNAsweretranscribedusingT7polymeraseandtransfectedintofelinecells(AK-D)previouslyinfectedwithfMHV-JHM(arecombinantMHVstrainencodingthefelinesurface(S)glycoprotein).fMHV-JHMdoesnotinfectmurinecells,butrecombinantvirusexpressingtheMHVSproteindoes,allowingforefficientselectionofrecombinantviru...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第7期SpecialTurkuCoronaryRiskFactorInterventionProjectforBabies(STRIP)
...ratoryResearchUnit,UniversityofTurku,Finland.2PresentedatthesymposiumFatIntakeDuringChildhood,heldinHouston,June89,1998.3AddresscorrespondencetoOSimell,DepartmentofPediatrics,UniversityofTurku,Kiinamyllynkatu48,20520Turku,Finland.E-mail:olli.simell{at}utu.fi.ABSTRACTBackground:Introducin...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年72卷第5期ReceptorTyrosineKinaseEphBIsaSurvivalFactorinBreastCancer
...,anti-mouseEphB4wasfromR&DSystems,Inc.(Minneapolis,MN),anti-proteinkinaseB(Akt)andanti-p-AktwerefromCellSignalingTechnology(Beverly,MA),andanti-humanFcwasfromJacksonLaboratories(BarHarbor,ME).Monoclonalantibodyagainstphosphotyrosine(clone4G10)wasfromUpstate(LakePlacid,NY),anti-Ki-67wasfromDAKO(Carpe...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第7期EnhancedPIP3signalinginPOMCneuronscausesKATPchannelactivationandleadstodiet-sensitiveobesity
...HungarianAcademyofSciences,Budapest,Hungary.11DepartmentofMolecularBiology,AkitaUniversitySchoolofMedicine,Akita,Japan.12DepartmentofMedicalBiophysics,andAdvancedMedicalDiscoveryInstituteandTheCampbellFamilyInstituteforBreastCancerResearch,OntarioCancerInstitute,UniversityofToronto,Toronto,Ontario,C...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第7期