Tightjunctionbiologyandkidneydysfunction
...einloss,adailyalbuminexcretionof40ginapatientwithaglomerularfiltrationrate(GFR)of100liters/dayrepresentsonly1%ofthealbuminthatcouldhavebeenlost(assuminganormalbloodalbuminconcentrationof40g/l)or2%ifbloodalbuminlevelisonlyhalfthatofnormal.TheobservationthatpodocyteeffacementwithlossofGSDcanalsobeseen...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第1期AlteredexpressionofrenalapicalplasmamembraneNa+transportersintheearlyphaseofgenetichypertension
...edMilannormotensive(MNS)ratswereusedascontrols.Theglomerularfiltrationrate(GFR),measuredbyinulinclearance,washigherinMHSthaninMNSrats,whilethemeanbloodpressurewasnotdifferentinthetwostrainsofanimalsindicatingthattheMHSratswerestillintheprehypertensivestate.Type3sodium/hydrogenexchanger(NHE3),bumetan...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第6期BiphasiceffectsofANPinfusioninconscious,euvolumicrats:rolesofAQP2andENaCtrafficking
...nalexcretions(FE)werecalculatedbythestandardformulasasfollows:C=UxV/P;FE=C/GFR,whereUisurineconcentration,Vistheurineflowrate,Pistheplasmaconcentration,andGFRistheglomerularfiltrationrateasmeasuredby[3H]inulinclearance.Cellculture.pCDNAI/NeowithratcDNAencodingAQP2(taggedwithaCOOH-terminalc-mycepitop...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第3期Androgensaugmentproximaltubuletransport
...theter(8).GlomerularFiltrationRateDeterminationTheglomerularfiltrationrate(GFR)wasmeasuredinratsfromboththeDHT-andvehicle-injectedgroups.Briefly,ratswerepreparedsurgicallyasdescribedabove.Theyweresubsequentlygivenanintravenousinjectionof[3H]inulin(60µCi)followedbyaninfusionof[3H]inulininnormal...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第9期Intrarenaloctreotidetreatmentpreventssodiumretentioninlivercirrhoticrats:evidencefordirecteffectswithinthethickascendinglimbofHenle‘
...alplasmaflow(ERPF),[3H]inulinclearanceasamarkerforglomerularfiltrationrate(GFR),andlithiumclearanceasamarkerforthedeliveryoffluidfromtheproximaltubule.Renalclearances(C)andfractionalexcretions(FE)werecalculatedbythestandardformulawhereUisconcentrationinurine,Visurineflowrate,andPisplasmaconcentratio...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第9期DeficiencyofEndothelialNitric-OxideSynthaseConfersSusceptibilitytoDiabeticNephropathyinNephropathy-ResistantInbredMice
...ahydrobiopterinavailabilitycauseseNOSuncoupling,whichdivertselectronsflowingfromeNOSreductasedomaintotheoxygenasedomaintomolecularoxygenratherthantoL-arginine,leadingtoexcessivesuperoxideproductionandreducedNOsynthesis.4,5Inaddition,chronicexposuretohyperglycemiaandaccumulationofadvancedglycationend...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第5期利尿劑在治療高血壓病中的作用
...促進Na+、K+交換,引起K+排出增加;也降低腎小球濾過率(GFR),抑制腎小管分泌尿酸;降低糖耐量及胰島素敏感性的作用可能與低血鉀有關,保鉀利尿劑如安體舒通無此類副反應,其排鉀和鎂的作用能加重洋地黃引起的心律紊亂,...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2005年第3卷第1期常用抗高血壓藥的不良反應及對策
...RBs對出球小動脈和入球小動脈擴張作用相當,故較少引起GFR下降,導致腎功能惡化者相對少見。ARBs常用於對ACE抑制劑不易耐受的高血壓、心力衰竭患者。 4β受體阻滯劑(β阻滯劑) β阻滯劑用於降壓也有40餘年...
醫源資料庫;在線期刊;濱州醫學院學報;2007年第30卷第5期Cyclooxygenase-2inhibitionnormalizesarterialbloodpressureinCYP1A1-REN2transgenicratswithinducibleANGII-dependentmalignanthypertension
...0.01).Therewasnodifferenceinrenalplasmaflow(RPF)orglomerularfiltrationrate(GFR)betweeninducedandnoninducedrats.NimesulideelicitedalargerdecreaseinMAPinhypertensiverats(188±6to140±8mmHg,P0.01)thaninnormotensiverats(136±4to113±8mmHg,P0.01).Additionally,nimesulidedecreasedGF...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第9期Poly(ADP-ribose)polymerase-1geneablationprotectsmicefromischemicrenalinjury
...ionsinPARP/andPARP+/+micewereassessedbydeterminingglomerularfiltrationrate(GFR)andtheplasmalevelsofcreatinine.ThelevelsofplasmacreatinineweredecreasedandGFRwasaugmentedinPARP/mice.MorphologicalevaluationofthekidneytissuesshowedthattheextentofdamageduetotheinjuryinPARP/micewaslesscomparedwiththeirwil...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第2期