Hemolysis-associatedendothelialdysfunctionmediatedbyacceleratedNOinactivationbydecompartmentalizedoxyhemoglobin
...eMedicineDepartment,NIH,Bethesda,Maryland,USA.2MolecularMedicineBranch,NIDDK,NIH,Bethesda,Maryland,USA.3DepartmentofSurgery,MassachusettsGeneralHospital,Boston,Massachusetts,USA.4VascularMedicineBranch,NationalHeart,Lung,andBloodInstitute(NHLBI),NIH,Bethesda,Maryland,USA.5RenalDiagnosticsandTherapeu...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第12期Pollen-associatedphytoprostanesinhibitdendriticcellinterleukin-12productionandaugmentThelpertype2cellpolarization
...iccells(DCs)asdocumentedbyphenotypicalandfunctionalmaturationandalteredcytokineproduction.BetulaalbaL.aqueouspollenextracts(Bet.-APE)selectivelyinhibitedinterleukin(IL)-12p70productionoflipopolysaccharide(LPS)-orCD40L-activatedDC,whereasIL-6,IL-10,andTNFremainedunchanged.PresenceofBet.-APEduringDCac...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第4期Pharmacologicalmanipulationofcelldeath:clinicalapplicationsinsight?
...entedcelerityduringthelastdecade,leadingtothedesignofnovelstrategiesforblockingpathologicalcelllossorforkillingunwantedcells.Thus,anincreasingnumberofcompoundstargetingadiverserangeofapoptosis-relatedmoleculesarebeingexploredatthepreclinicalandclinicallevels.BeyondtheagentsthatarealreadyFDAapproved,...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期囊性纖維化
...能不全及肝硬化。【診斷】根據梗阻性黃疸、肝腫大、門脈高壓等臨牀表現;血清ALT、AST及鹼性磷酸酶升高;膽囊造影不顯影;汗液中氯化物增加及肝活檢異常可以確立診斷。【治療措施】刺激膽汁分泌的藥物無效,用生理鹽水...
求醫問藥;疾病手冊;消化內科Hemeoxygenase-1isamodulatorofinflammationandvaso-occlusionintransgenicsicklemice
...IsraelDeaconessMedicalCenter,Boston,Massachusetts,USA.AbstractTransgenicsicklemiceexpressing?ShemoglobinhaveactivatedvascularendotheliumthatexhibitsenhancedexpressionofNF-Bandadhesionmoleculesthatpromotevascularstasisinsickle,butnotinnormal,miceinresponsetohypoxia/reoxygenation.Sicklemicehemolyzerbc...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期鉤藤總鹼
...觀察鉤藤總鹼對犬心功能的影響。1次靜脈給藥(20mg/kg),心臟泵功能指標左心室壓(LVP)、頸動脈血壓(AP)、心率(HR)和總外周血管阻力(TPVR)分別減少17.9%,27.6%,24.8%和23.17%(P<0.01)。同時,左室舒張...
藥品天地;專業藥學;中藥大全;中草藥有效成分Pathogenicroleforskinmacrophagesinamousemodelofkeratinocyte-inducedpsoriasis-likeskininflammation
...Biology,FreeUniversity,Amsterdam,TheNetherlands.AbstractPsoriasisisacommonskindisease,thepathogenesisofwhichhasnotyetbeenresolved.Inmice,epidermis-specificdeletionofinhibitorofNF-B(IB)kinase2(IKK2)resultsinaskinphenotypethatmimicshumanpsoriasisinseveralaspects.Likepsoriasis,thisskindiseaseshowsprono...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第8期UniqueEndemicityofCryptosporidiosisinChildreninKuwait
...andHumanServices,Atlanta,GeorgiaDepartmentofMicrobiology,FacultyofMedicine,KuwaitUniversity,Safat,KuwaitDepartmentofLaboratories,FarwaniyaDistrictHospital,Farwaniya,KuwaitDepartmentofLaboratories,JahraHospital,AlJahra,KuwaitDepartmentofLaboratories,MubarakHospital,KuwaitCity,KuwaitABSTRACTToundersta...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第6期ATP-sensitivepotassiumchannelopathies:focusoninsulinsecretion
UniversityLaboratoryofPhysiology,OxfordUniversity,Oxford,UnitedKingdom.AbstractATP-sensitivepotassium(KATP)channels,sonamedbecausetheyareinhibitedbyintracellularATP,playkeyphysiologicalrolesinmanytissues.Inpancreatic?cells,thesechannelsregulateglucose-dependentinsulinsecretionandserveasthetargetfors...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第8期Senescence-associatedphenotypesinAkitadiabeticmiceareenhancedbyabsenceofbradykininB2receptors
...tgeneticallyincreasedangiotensin-convertingenzymelevels,orabsenceofthebradykininB2receptor,increasekidneydamageindiabeticmice.Wedemonstrateherethatthisispartofamoregeneralphenomenon—diabetesand,toalesserdegree,absenceoftheB2receptor,independentlybutalsolargelyadditivelywhencombined,enhancesenescen...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第5期