MolecularSignallingMediatingtheProtectiveEffectofA1AdenosineandmGlu3MetabotropicGlutamateReceptorActivationagainstApoptosisbyOxygen/Glucose
...ributestothepathophysiologyofshort-andlong-termneurodegenerativedisorders(Takumaetal.,2004).ApoptoticastrocytesarefoundinAlzheimer‘sdisease(Kobayashietal.,2002),ischemicdemyelinatinglesionsinvasculardementia(Tomimotoetal.,1997),andinthegraymatteroffrontotemporaldementia(Martinetal.,2000).Moreover,...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第5期PharmacologicalmanipulationofBcl-2familymemberstocontrolcelldeath
...ldeath,asincancer.TheBcl-2familyofproteinsBcl-2wasinitiallyclonedfromthebreakpointofthet(14;18)chromosomaltranslocationfoundinthevastmajorityofpatientswithfollicularlymphoma,anindolentBcellnon-Hodgkinlymphoma(1-3).ExpressionofBcl-2blockedcelldeathfollowingnumerouscellinsults(4,5).Asatestofitsoncogen...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期IdentificationandcharacterizationofanendogenouschemotacticligandspecificforFPRL2
...heMarioNegri,20157Milano,ItalyChemotaxisofdendriticcells(DCs)andmonocytesisakeystepintheinitiationofanadequateimmuneresponse.Formylpeptidereceptor(FPR)andFPR-likereceptor(FPRL)1,twoGprotein–coupledreceptorsbelongingtotheFPRfamily,playanessentialroleinhostdefensemechanismsagainstbacterialinfectiona...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第1期Oxidantstressfromnitricoxidesynthase–3uncouplingstimulatescardiacpathologicremodelingfromchronicpressureload
...gbyactivatingMMPs(3,14).ROScanbegeneratedbymitochondrialelectrontransportleakage(10,15),NADPHoxidases(3,16,17),xanthineoxidase(18),andnitricoxidesynthase(NOS)(19,20).Amongthese,NOSisintriguingbecauseNOanditsdownstreamtarget,proteinkinaseG,aregenerallyconsideredtoblunthypertrophy(21-24).However,NOSca...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第5期Dualphaseregulationofexperimentalallergicencephalomyelitisbyplatelet-activatingfactor
...yofmacrophageswasmeasuredinthepresenceorabsenceofPAF.AsshowninFig.7A,theuptakeoffluorescentparticleswassimilarbetweenPAFR-WTandPAFR-KOcellsinthesteady-state.PhagocytosiswasenhancedapproximatelytwofoldinthepresenceofPAFinPAFR-WTcells,whereastherewasnoeffectofPAFonPAFR-KOcells.TNF-productionalsowasup-...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第6期UltrasoundStimulatesCyclooxygenase-2ExpressionandIncreasesBoneFormationthroughIntegrin,FocalAdhesionKinase,Phosphatidylinositol3-Kinase,andAkt
...OX-2).Atthemechanisticlevel,anti-integrin51andv3antibodiesorrhodostomin,asnakevenomdisintegrin,attenuatedtheUS-inducedCOX-2expression.Phosphatidylinositol3-kinase(PI3K)inhibitors2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-onehydrochloride(LY294002)andwortmanninalsoinhibitedthepotentiatingactionofU...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期TheCCR5Receptor-BasedMechanismofActionof873140,aPotentAllostericNoncompetitiveHIVEntryInhibitor
...o-hepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminiumchloride(TAK779)blockedthebindingofbothchemokines125I-MIP-1(alsoknownas125I-CCL3,125I-LD78)and125I-RANTES(125I-CCL5),873140wasanineffectualantagonistof125I-RANTES(regulatedonactivationnormalTcellexpressedandsecreted)binding(butdidblock...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第4期ProtectionfromangiotensinII–mediatedvasculotoxicandhypertensiveresponseinmicelackingPI3K
...ggeringofROSproduction.Conversely,PI3KwasnecessarytoactivateproteinkinaseB/Akt,which,inturn,enhancedL-typeCa2+channel–mediatedextracellularCa2+entry.ThesedataindicatethatPI3KisakeytransduceroftheintracellularsignalsthatareevokedbyangiotensinIIandsuggestthatblockingPI3Kfunctionmightbeexploitedtoimp...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第8期Nedd4
...oocytes,whereastheinteractionwithandfunctionaleffectofNedd42WW2,3onENaCisweak.Nedd42isexpressedinthemousecollectingduct,andoverexpressionofNedd42reducesendogenousENaCactivityinacollectingductcellline.ThisreductioninENaCactivitycanbereversedearlywithexposuretodexamethasone,aneffectthatisassociatedwit...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第9期NanomolarandMicromolarEffectsof15-Deoxy-12,14-prostaglandinJ2onAmnion-DerivedWISHEpithelialCells:DifferentialRolesofPeroxisomeProliferator-Act
...sanimportantroleintrophoblastdifferentiationandplacentalvascularization(Baraketal.,1999).NF-Bisacrucialtransactivatorofmultipleproinflammatoryandanti-apoptoticgenes(Lawrenceetal.,2002).Recentstudieshavedemonstratedthat15d-PGJ2inhibitsthesignalingstepsleadingtoNF-Bactivationbysequesteringcoactivators...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第1期