多發性硬化患者血清sIL-6R水平觀察
...RUMANDITSCLINICALSIGNIFICANCEINPATIENTSWITHMULTIPLESCLEROSISHeZhiyi,LuChanglong,Liufengzhi,WangGang,FuGuo,LiShaoying (DepartmentofNeurology,TheFirstAffiliatedHospital,ChinaMedicalUniversity,Shenyang110001) AbstractTostudytheeffectofsolubleinterleukin-6receptor(sIL-6R...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學RepressionofHumanGSTA1byInterleukin-1IsMediatedbyVariantHepaticNuclearFactor-1C
...tionsincytoprotectionagainsttoxicby-productsoflipidperoxidationproducedduringinflammation.Weinvestigatedtheroleofhepaticnuclearfactor1(HNF-1)inrepressionofhumanGSTA1expressionbyinterleukin(IL)-1inCaco-2cells.Inluciferasereporterassays,overexpressionofHNF-1increasedGSTA1transcriptionalactivityviaanHN...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期Macrophageinflammatoryprotein–1asacostimulatorysignalformastcell–mediatedimmediatehypersensitivityreactions
...,UniversityofLondon,InstitutesofOphthalmologyandChildHealth,London,UnitedKingdom.2DepartmentofBiochemistry,MeharryMedicalCollege,Nashville,Tennessee,USA.AbstractRegulationoftheimmuneresponserequiresthecooperationofmultiplesignalsintheactivationofeffectorcells.Forexample,Tcellsrequiresignalsemanating...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第2期肌紅蛋白測定在急性心肌梗塞診斷中的臨牀意義
...估AMI預後和判定梗塞面積的一個良好指標。TheClinicalMeaningsofSerumMyoglobinLevel inTheDiagnosisofAcuteMyocardialInfarctionXiaoyuyan,XingYanfang,ShengJianmin (DepartmentofInternalMedicine,TianjinGongAnHospital,Tianjin300050) Abstract Tostudythecharacterofincrease...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學ThematrixcomponentbiglycanisproinflammatoryandsignalsthroughToll-likereceptors4and2inmacrophages
...crophagesasanendogenousligandofTLR4andTLR2,whichmediateinnateimmunity,leadingtorapidactivationofp38,ERK,andNF-BandtherebystimulatingtheexpressionofTNF-andmacrophageinflammatoryprotein–2(MIP-2).Inagreement,thestimulatoryeffectsofbiglycanaresignificantlyreducedinTLR4-mutant(TLR4-M),TLR2–/–,andmy...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第8期ImpactofSerumAmyloidAonTissueFactorandTissueFactorPathwayInhibitorExpressionandActivityinEndothelialCells
...SAAalsodirectlyinducedactivationofMAPkinasesandNFB.Conclusions-ThestimulatingeffectofSAAwasfaster-actingontheexpressionandactivityofTFandtheinhibitoryeffectwasslower-actingonTFPI.TheeffectsaremediatedthroughFPRL1,MAPkinasesandNFB.ThisstudyinvestigatestheimpactofSAAontheexpressionandactivityofTFandTF...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第7期DiagnosisofInvasivePneumococcalInfectionbySerotype-SpecificUrinaryAntigenDetection
...TDepartmentofMicrobiology,TauntonandSomersetHospital,TauntonTA15DB,UnitedKingdomABSTRACTWidespreaduseofconjugatepneumococcalpolysaccharide-proteinvaccinesmayalterthespectrumofpneumococciproducinginvasivedisease.Novelsensitivediagnosticmethodswouldbevaluableformonitoringtheepidemiologyofpneumococcald...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期AgingintheAtherosclerosisMilieuMayAcceleratetheConsumptionofBoneMarrowEndothelialProgenitorCells
【摘要】Objective-Wehavedemonstratedthatbonemarrowcellsfromyoungandwild-type(WT),butnotoldapoE-/-,micearecapableofpreventingatherosclerosis.Thisstudywasperformedtoelucidatethenumericalandfunctionalchangesunderlyingtheefficacydifferencebetweenyoungandoldbonemarrow.MethodsandResults-CD34+/VEGFR2+c...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第1期頂空固相微萃取氣相色譜法測定水中有機氯化合物
...烷探頭進行比較。結果12種有機氯農藥的檢出限均小於35.3ng/L;相對標準偏差RSD≤11.8%(n=3);線性係數都大於0.990;回收率範圍71.5%~115.5%。結論溶膠凝膠聚甲基苯基乙烯基硅氧烷探頭萃取效率比商用進口聚二甲基硅氧烷探頭高...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2007年第7卷第8期TransformingGrowthFactor-ß-InducedExpressionoftheApolipoproteinEGeneRequiresc-JunN-TerminalKinase,p38Kinase,andCaseinKinase
【摘要】Objective-Thecytokinetransforminggrowthfactor-ß(TGF-ß)andapolipoproteinE(apoE)playpotentantiatherogenicroles.Despitesuchimportance,themechanismsunderlyingtheregulationofapoEexpressionbyTGF-ßhavenotbeencharacterizedandwerethereforeinvestigated.MethodsandResults-UsingTHP-...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第6期