液相色譜串聯質譜法測定兔血漿中葛根素的濃度
...子化後以多反應離子監測方式測定。結果葛根素在10~3000ng·mL-1線性良好(r=0.9986),檢測限爲10ng·mL-1,回收率爲99.91%~103.92%,絕對回收率爲91.33%~100.40%,日內、日間變異(RSD)均≤15%,色譜峯保留時間爲1.67min。結論方法靈敏、準確...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文CD28CostimulationIsRequiredforInVivoInductionofPeripheralToleranceinCD8TCells
...ExperimentalImmunologyBranch,NationalCancerInstitute2NationalInstituteonAging,NationalInstitutesofHealth,Bethesda,MD20892 Abstract:TopAbstractIntroductionMaterialsandMethodsResultsDiscussionReferences:WhereasligationofCD28isknowntoprovideacriticalcostimulatorysignalforactivationofCD4Tcells,the...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第1期考古DNA檢測技術引發質疑歷史命題需重究溯源
...其應用也助解了不少謎題,比如業內比較熟知的C-14法,然而,DNA檢測技術的應用卻引來了爭議,一方說辭在於人類經過多年遷徙和發展,基因可能會發生變化,而另一觀點則運用中外實例證實古DNA考古已基本得到認可。基因突...
醫藥經濟;生物技術;技術要聞DistinctDiversityofvacA,cagA,andcagEGenesofHelicobacterpyloriAssociatedwithPepticUlcerinJapan
...uateSchoolofScience,HokkaidoUniversity,Sapporo,JapanFrontierMedicalScienceinGastroenterology,InternationalCenterforMedicalResearchandTreatment,KobeUniversitySchoolofMedicine,Kobe,JapanABSTRACTColonizationofthestomachmucosabyHelicobacterpyloriisamajorcauseofacuteandchronicgastricpathologiesinhumans.S...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第8期CentralRoleofPKCinNeointimalExpansionTriggeredbyAcuteArterialInjury
...isoform,inacutehypoxicstress.5eC6HypoxiainducesrapidactivationofPKCII,leadingtoactivationofRaf,mitogen-activatedproteinkinase/extracellularsignalregulatedproteinkinasekinaseandmitogen-activatedproteinkinases7:eventscentraltoPKC-inducedtranscriptionalregulationofEgr-1.Inamurinemodelofsinglelungischem...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第3期Neutrophilsfromp40phox–/–miceexhibitseveredefectsinNADPHoxidaseregulationandoxidant-dependentbacterialkilling
1InositideLaboratory2LaboratoryofMolecularSignalling,TheBabrahamInstitute,BabrahamResearchCampus,CambridgeCB24AT,UKThegenerationofreactiveoxygenspecies(ROS)bythereducednicotinamideadeninedinucleotidephosphate(NADPH)oxidasecomplexplaysacriticalroleintheantimicrobialfunctionsofthephagocyticcellsofthei...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第8期NeurotrophinspromoterevascularizationbylocalrecruitmentofTrkB+endothelialcellsandsystemicmobilizationofhematopoieticprogenitors
...phicfactor(BDNF)isrequiredforthemaintenanceofcardiacvesselwallstabilityduringembryonicdevelopmentthroughdirectangiogenicactionsonendothelialcellsexpressingthetropomysinreceptorkinaseB(TrkB).However,theroleofBDNFandarelatedneurotrophinligand,neurotrophin-4(NT-4),intheregulationofrevascularizationofth...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期ERKpandSmadSignalingPathwaysDifferentiallyRegulateTransformingGrowthFactor-ßAutoinductioninProximalTubularEpithelialCells
【摘要】Transforminggrowthfactor(TGF)-ß1isamediatorofthefinalcommonpathwayoffibrosisassociatedwithprogressiverenaldisease,aprocessinwhichproximaltubularcells(PTCs)areknowntoplayanimportantpart.TheaimofthecurrentstudywastoexaminethemechanismofPTCTGF-ß1autoinduction.TheadditionofTGF-&s...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第10期SynergyofIL-21andIL-15inregulatingCD8+Tcellexpansionandfunction
1LaboratoryofMolecularImmunology,NationalHeart,Lung,andBloodInstitute2SurgeryBranch,NationalCancerInstitute,NationalInstitutesofHealth,Bethesda,MD208923VaccineBranch,NationalCancerInstitute,NationalInstitutesofHealth,Bethesda,MD208924LaboratoryofCellularOncology,NationalCancerInstitute,NationalInsti...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第1期InhibitionofTumorNecrosisFactor-throughSelectiveBlockadeofPre-mRNASplicingbyShikonin
【關鍵詞】InhibitionWepreviouslydevelopedagene-gun-basedinvivoscreeningsystemandidentifiedshikoninasapotentsuppressoroftumornecrosisfactor-(TNF-)geneexpression.Here,weshowthatshikoninselectivelyinhibitstheexpressionofTNF-attheRNAsplicinglevel.Treatmentoflipopolysaccharide-stimulatedhumanprimary...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第6期