IL-12–andIL-23–inducedThelpercellsubsets:birdsofthesamefeatherflocktogether
...lperTcells.Nat.Rev.Immunol.2:933–944.Monney,L.,C.A.Sabatos,J.L.Gaglia,A.Ryu,H.Waldner,T.Chernova,S.Manning,E.A.Greenfield,A.J.Coyle,R.A.Sobel,G.J.Freeman,andV.K.Kuchroo.2002.Th1-specificcellsurfaceproteinTim-3regulatesmacrophageactivationandseverityofanautoimmunedisease.Nature.415:536–541.Szabo,...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第2期Increasedglucosetoleranceandreducedadiposityintheabsenceoffastinghypoglycemiainmicewithliver-specificGsdeficiency
...ngpropertiesoftheratglucagonreceptor.Science.259::1614-1616.Weinstein,L.S.,Yu,S.,Warner,D.R.,andLiu,J.2001..EndocrinemanifestationsofstimulatoryGprotein-subunitmutationsandtheroleofgenomicimprinting.Endocr.Rev.22::675-705.Montminy,M.1997..TranscriptionalregulationbycyclicAMP.Annu.Rev.Biochem.66::807...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第11期MaintenanceofviralsuppressioninHIV-1–infectedHLA-B57+elitesuppressorsdespiteCTLescapemutations
...surebyCTLsisimportantforthecontrolofviremiainES.AlthoughESmaintainclinicallyundetectableviralloads,weshowherethatfreeviruscanbedetectedintheplasmaofmostoftheseindividualsusingsensitiveRT-PCRassays.Weamplifiednearfull-lengthgaggenesfromthisplasmavirusandfromproviralDNAinrestingCD4+Tcells,allowingsequ...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第5期Cytokinesignaltransductionissuppressedinpreselectiondouble-positivethymocytesandrestoredbypositiveselection
...glepositive;SOCS,suppressorofcytokinesignaling;TFU,totalfluorescenceunit.Q.YuandJ.-H.Parkcontributedequallytothiswork.Q.Yu‘spresentaddressisLaboratoryofImmunology,NationalInstituteonAging,Baltimore,MD21224.DevelopmentandsurvivalofTcellsinthethymusdependonsignalstransducedbybothTCRsandcytokinerecep...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期IntratumordepletionofCD4+cellsunmaskstumorimmunogenicityleadingtotherejectionoflate-stagetumors
...enageneralconcernthatthedepletionofCD4+CD25+Tcellsinthetumor-bearinghostsmayunwittinglyeliminatethehelperfunctionofCD4+Tcells,whichcanalsoexpresstheCD25+markerafteractivationbytumororbyvaccination.WeproposethatCD4+cellspredominatelyplayanenhancinghelperroleduringtheinitialstages,butoncetumorsbecomec...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第5期InductionofAPOBEC3familyproteins,adefensivemaneuverunderlyinginterferon-inducedanti–HIV-1activity
...ringviralsynthesistocombatinfectivity.APOBEC3Gdeaminatesdeoxycytidinetodeoxyuridineofminussingle–strandnascentviralDNAduringreversetranscription,whichresultsinhypermutationofplus-strandDNA.ThisenzymaticeditingofHIVreversetranscriptsleadstodegradationofdeaminatedminus-strandDNA(2–4)andblockadeofH...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期Removalofhomeostaticcytokinesinksbylymphodepletionenhancestheefficacyofadoptivelytransferredtumor-specificCD8+Tcells
...hemotherapyregimenof250mg/kgCytoxan+50mg/kgfludarabine(acombinationcurrentlyusedintheclinic;Fig.1a)(11).Transferof107pmel-1cellsincombinationwithvaccinationandIL-2caneradicateestablishedB16tumors(22).Wethusgavealogfewer(106cellsinallexperiments)togenerateatreatmentwindow.Tumortreatmentwassignificant...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第7期Loop-MediatedIsothermalAmplificationMethodforRapidDetectionofthePeriodontopathicBacteriaPorphyromonasgingivalis,Tannerellaforsythia,andTrepone
DivisionofCommunityOralHealthScience,KyushuDentalCollege,KitakyushuEikenChemicalCo.,Ltd.,Tochigi,JapanABSTRACTLoop-mediatedisothermalamplification(LAMP),anovelnucleicacidamplificationmethod,wasdevelopedfortherapiddetectionofthemajorperiodontalpathogensPorphyromonasgingivalis,Tannerellaforsythia,andT...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第5期FASL–844Cpolymorphismisassociatedwithincreasedactivation-inducedTcelldeathandriskofcervicalcancer
...essionofbothFASandFASLonactivationbyantigenorotherstimulationandsubsequentlyundergo“suicide“or“fratricide“byFASLligandingtoFAS(7,8).AntigenicstimulationwithinthetumormicroenvironmentmightalsobeinvolvedintheenhancedexpressionandfunctionofFASLonTcells,resultinginactivationofautocrineorparacrin...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第7期UseofSeveralInducerandSubstrateAntibioticCombinationsinaDiskApproximationAssayFormatToScreenforAmpCInductioninPatientIsolatesofPseudomo
...recollectedovera3-monthperiodfromMaythroughJuly2005.IsolateswereidentifiedbyusingeithertheVITEK2colorimetricorAPIidentificationsystems(bioMerieuxSA,Marcyl‘Etoile,France).Thecollectionconsistedof134P.aeruginosastrainsand13Citrobacter(9freundii,3koserii,and1amalonaticus),13Serratiamarcescens,and40En...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第12期