AnomalousRenalEffectsofTinProtoporphyrininaMurineModelofSickleCellDisease
【摘要】Inhumanandmurinemodelsofsicklecelldisease(SCD),hemeoxygenase-1(HO-1)isinducedinthekidney,anorgancommonlyinvolvedinSCD.ThepresentstudyassessedtheroleofHO-1byusingacompetitiveinhibitorofHOactivity,tinprotoporphyrin(SnPP),inprotocolsaffordingacomposite,clinicallyrelevantanalysisofthekidneyi...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第7期EffectofischemicacuterenaldamageontheexpressionofCOX-2andoxidativestress-relatedelementsinratkidney
...isaclinicalsyndromecharacterizedbydeteriorationofrenalfunctionoveraperiodofhoursordays.TheprincipalcausesofARFareischemicandtoxicinsultsthatcaninducetissuehypoxia.Transcriptionalresponsestohypoxiacanbeinflammatoryoradaptivewiththeparticipationofthehypoxia-induciblefactor1andtheexpressionofspecificge...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第5期Hemin-activatedmacrophageshometothepancreasandprotectfromacutepancreatitisviahemeoxygenase-1induction
...entofPediatrics,StanfordUniversity,Stanford,California,USA.4DepartmentofPathology,VAPaloAltoHealthCareSystem,PaloAlto,California,USA.AbstractHeminupregulateshemeoxygenase-1(HO-1),astress-inducedenzymeimplicatedinprotectionfromavarietyofinjurieswhileitsrelatedisoformHO-2isconstitutivelyexpressed.Ther...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第11期腹腔鏡CO2氣腹對裸鼠卵巢癌腹腔內生長和擴散的影響
...腔內生長和擴散的影響。方法50只裸鼠腹腔內注射卵巢癌HO-8910細胞,於14天后按不同手術要求分組如下:(1)對照組(GA,僅僅實施麻醉);(2)開腹組(ML,恥骨聯合上正中切口長約2cm進腹,將腸管等臟器取出擱置在無菌鹽紗...
醫源資料庫;在線期刊;中華現代婦產科學雜誌;2009年第6卷第1期HemeOxygenase-AttenuatesOvalbumin-InducedAirwayInflammationbyUp-RegulationofFoxpT-RegulatoryCellsInterleukin-0andMembrane-BoundTransformingGro
...egulatory(Treg)cellsisimplicatedinanti-inflammatoryeffectofhemeoxygenase-1(HO-1).Thus,wepostulatedthatinductionofHO-1couldaugmentIL-10andtransforminggrowthfactor(TGF)-??productionandfoxp3+CD4+CD25+Tregcellfunction,therebyleadingtoattenuationofairwayinflammation.Inthisstudy,CD4+CD25+Tregcellsisolated...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第12期ChryseobacteriumindologenesNon-Catheter-RelatedBacteremiainaPatientwithaSolidTumor
DepartmentofMicrobiologyFirstDepartmentofMedicalOncology,METAXAAnticancerHospital,PiraeusDepartmentofMicrobiology,MedicalSchooloftheUniversityofAthens,Athens,GreeceABSTRACTAcaseofnon-catheter-relatedbacteremiacausedbyChryseobacteriumindologenesinanonneutropenicmanwithasolidtumorisdescribed.Thepatien...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第4期動脈粥樣硬化發病中冠狀動脈內源性一氧化碳及血紅素氧化酶-1的變化(基金項目)
...化碳(CO)及其合成酶—血紅素氧化酶-1(HemeOxygenase-1,HO-1)在冠狀動脈粥樣硬化疾病發展中的變化規律。方法通過逆轉錄PCR、原位雜交、免疫組織化學染色、生物化學多項指標觀察動脈粥樣硬化發病過程中HO-1和CO等相關指標變...
資料庫;在線期刊;中華現代內科學雜誌;2004年第1卷第1期HepaticIschemia-ReperfusionInducesRenalHemeOxygenase-1viaNF-E2-RelatedFactor2inRatsandMice
...ase,leadingtolocalizedhepaticinjuryandremoteorgandysfunction.Hemeoxygenase(HO)-1isanenzymethatisinducedbyvariousstimuli,includingproinflammatorycytokines,andexertsantioxidativeandanti-inflammatoryfunctions.Up-regulationofHO-1isknowntoprotectagainsthepaticIRinjury,buttheeffectsofhepaticIRonthekidneya...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期血紅素加氧酶-1在器官移植中的保護作用
...損傷和急慢性排斥反應。血紅素加氧酶-1(Hemeoxygenase-1,HO-1)是血紅素蛋白代謝產生膽紅素、CO、Fe2+途徑中的限速酶,具有明顯的細胞保護作用。大量研究發現,HO-1表達增加對移植物起到保護作用並且延長移植物存活時間。本...
資料庫;在線期刊;中華現代兒科學雜誌;2004年第1卷第4期Antioxidantsprotectfromatherosclerosisbyahemeoxygenase-1pathwaythatisindependentoffreeradicalscavenging
1CentreforVascularResearch,SchoolofMedicalSciences,UniversityofNewSouthWales,andDepartmentofHaematology,PrinceofWalesHospital,SydneyNSW2052,Australia2EasternHeartClinic,PrinceofWalesHospital,SydneyNSW2031,Australia3DepartmentofMedicine,UniversityofSydney,andDepartmentofCardiology,RoyalPrinceAlfredHo...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期