DifferentiallocalizationofmammalianLin-7(MALS/Veli)PDZproteinsinthekidney
...partmentofPhysiology,UniversityofCalifornia,SanFrancisco,CaliforniaABSTRACTLin-7PDZproteins,alsocalledMALSorVelis,havebeenshowntocoordinatebasolateralmembraneexpressionofvarioustargetproteinsinrenalepithelialcellmodels.ThreedifferentLin-7/MALS/Veliisoforms,encodedbyseparategenes,havebeenidentified.H...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第2期PKCregulatesBCR-mediatedIKKactivationbyfacilitatingtheinteractionbetweenTAK1andCARMA1
...TriggeringoftheBcellantigenreceptor(BCR)leadstotheinitiationofmultiplesignalingpathwaysthatregulatecellularproliferationandsurvivalofimmatureandnaiveBlymphocytes,andtheeffectorfunctionsofmatureBcells(1).Amongthem,thesignalingpathwaythatleadstotheactivationoftranscriptionfactorsofNF-Bhasacrucialrolei...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第10期LossofC/EBPcellcyclecontrolincreasesmyeloidprogenitorproliferationandtransformstheneutrophilgranulocytelineage
...ancerbindingprotein(C/EBP)isamyeloid-specifictranscriptionfactorthatcoupleslineagecommitmenttoterminaldifferentiationandcellcyclearrest,andisfoundmutatedin9%ofpatientswhohaveacutemyeloidleukemia(AML).WepreviouslyshowedthatmutationswhichdissociatetheabilityofC/EBPtoblockcellcycleprogressionthroughE2F...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第1期PU.1regulatesthecommitmentofadulthematopoieticprogenitorsandrestrictsgranulopoiesis
TheWalterandElizaHallInstituteofMedicalResearch,Parkville,Victoria3050,AustraliaAlthoughthetranscriptionfactorPU.1isessentialforfetallymphomyelopoiesis,weunexpectedlyfoundthateliminationofthegeneinadultmicealloweddisturbedhematopoiesis,dominatedbygranulocyteproduction.Impairedproductionoflymphocytes...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第9期PGC-1coactivators:inducibleregulatorsofenergymetabolisminhealthanddisease
...physiologicandnutritionalcuestocriticalgeneregulatoryresponses.Themolecularlinksbetweenexternalstimuli,cellularsignalingevents,andNR-mediatedtranscriptionalcontrolarecurrentlybeingunraveled.NewinformationemergingoverthepastdecadehasdemonstratedthatNRsreceiveregulatoryinputthroughmultiplemechanismsin...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期AgingintheAtherosclerosisMilieuMayAcceleratetheConsumptionofBoneMarrowEndothelialProgenitorCells
...ow.MethodsandResults-CD34+/VEGFR2+conventionalendothelialprogenitorcellsandlin-/cKit+/Sca-1+hematopoieticstemcellsdidnotdiffernumericallyorfunctionallybetweenyoungandoldapoE-/-bonemarrow.Fluorescence-activatedcellsorteranalysis,however,showedthatagroupofcells(simplelittlecellsorSLCs),characteristica...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第1期Identificationofeosinophillineage–committedprogenitorsinthemurinebonemarrow
...heInstituteofMedicalScience,UniversityofTokyo,Tokyo108-8639,JapanEosinophillineage–committedprogenitors(EoPs)arephenotypicallyisolatableinthesteady-statemurinebonemarrow.Purifiedgranulocyte/monocyteprogenitors(GMPs)gaverisetoeosinophilsaswellasneutrophilsandmonocytesatthesinglecelllevel.Withinthes...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第12期骨髓C-kit+Lin-細胞移植對小鼠四氯化碳性肝纖維化的影響*
【摘要】目的探討骨髓C-kit+Lin-細胞移植對肝纖維化病變的影響。方法16只四氯化碳性肝纖維化雌性小鼠隨機分爲移植組和對照組,移植組小鼠(n=8)接受同基因型雄性小鼠的骨髓C-kit+Lin-細胞移植,對照組小鼠(n=8)接受等體積...
醫源資料庫;在線期刊;中華醫學研究雜誌;2009年第9卷第5期膿毒症大鼠血清一氧化氮和內皮素-1水平變化的研究
...要功能是改善微循環,但在分泌失調時又引起嚴重的組織細胞缺血缺氧性損害。本文通過觀察膿毒症大鼠血清NO和ET-1水平的變化,以探討膿毒症時NO和ET-1在膿毒症時微循環障礙,血管通透性降低中的作用。 1材料與方法 1....
醫源資料庫;在線期刊;中華現代臨牀醫學雜誌;2009年第7卷第11期MolecularCharacterizationofHandFloraandEnvironmentalIsolatesinaCommunitySetting
ClinicalMicrobiologyLaboratory,DepartmentofPathology,NewYorkPresbyterianHospital,ColumbiaUniversityMedicalCenter,NewYork,NewYorkSpectralGenomics,Inc.,Houston,TexasCenterforSocialEpidemiologyPopulationHealth,AnnArbor,MichiganDepartmentofEpidemiology,JosephMailmanSchoolofPublicHealth,ColumbiaUniversit...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期