SuppressionofOsteoclastogenesisbyN,N-Dimethyl-D-erythro-sphingosine:ASphingosineKinaseInhibition-IndependentAction
【關鍵詞】SuppressionN,N-Dimethyl-D-erythro-sphingosine(DMS)competitivelyinhibitssphingosinekinase(SPHK)andhasbeenwidelyusedtoassesstheroleofSPHKduringcellularevents,includingmotility,proliferation,anddifferentiation.Inthepresentstudy,theeffectofDMSonthedifferentiationofbonemarrowmacrophages(BM...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第8期UR-1505,aNewSalicylate,BlocksTCellActivationthroughNuclearFactorofActivatedTCells
...kdescribestheimmunomodulatoryprofileofUR-1505.UR-1505targetsTcells,inhibitingtheirproliferationandcytokineproductionbyblockingnuclearfactorofactivatedTcells(NF-AT)DNA-bindingactivity.TheeffectsofUR-1505(100-300µM)onTcellproliferationseemstobedependentonthestimulus,becauseUR-1505inhibitedCD3/CD...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第8期三七、白芍及西洋參中氯氰菊酯、氰戊菊酯和溴氰菊酯的殘留量測定
...良好殺蟲效果的廣譜性農藥,在藥材種植中被廣泛應用,然而它存有一定的異構體,這就導致了建立其多殘留測定方法的困難性。儘管在農產品中其殘留測定方法已有報道[1~7],其溶劑系統有:丙酮-己烷、丙酮-二氯甲烷、...
藥品天地;專業藥學;實驗技術;色譜技術;色譜分析實例三七、白芍及西洋參中氯氰菊酯、氰戊菊酯和溴氰菊酯的殘留量測定
...良好殺蟲效果的廣譜性農藥,在藥材種植中被廣泛應用,然而它存有一定的異構體,這就導致了建立其多殘留測定方法的困難性。儘管在農產品中其殘留測定方法已有報道[1~7],其溶劑系統有:丙酮-己烷、丙酮-二氯甲烷、...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文單味中藥對子宮肌瘤之實驗研究
...言,全子宮切除(totalhystectomy)是治療子宮肌瘤的方法之一,然而臺灣地區子宮切除術是否有過於氾濫的情形常受質疑。有研究指出臺灣地區子宮切除率以臺北、臺中、高雄爲高。變異大多可由醫療資源分佈解釋,而子宮切除年齡最高...
醫源資料庫;在線期刊;中華現代臨牀醫學雜誌;2005年第3卷第20期HMG-CoAreductaseinhibitorsimvastatinmitigatesVEGF-inducedinside-outsignalingtoextracellularmatrixbypreventingRhoAactivation
...meA(HMG-CoA)reductaseinhibitorsexertmodulatoryeffectsonanumberofcellsignalingcascadesbypreventingthesynthesisofvariousisoprenoidsderivedfromthemevalonatepathway.Inthepresentstudy,wedescribeanovelpleiotropiceffectofHMG-CoAreductaseinhibitors,alsocommonlyknownasstatins,onvascularendothelialgrowthfacto...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第11期雷公藤內酯醇誘導人淋巴細胞凋亡的作用與細胞週期的關係
...cellcycleandapoptosisofactivatedTlymphocyctes inducedbytriptolideLIUDong,YANGJun-Wei,CHENZhao-Hongetal. ResearchInstituteofNephrology,JinlingHospital,SchoolofMedicine,NanjingUniversity,Nanjing210002 Abstract Objective:Inordertoexploredthemechanismsoftriptolide-inducedapoptosis,there...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學UseofDipsticksforRapidDiagnosisofCholeraCausedbyVibriocholeraeO1andO139fromRectalSwabs
...inicalSciencesDivisions,InternationalCentreforDiarrhoealDiseasesResearch,Bangladesh(ICDDR,B),Dhaka1212,Bangladesh,1InstitutPasteur,Paris,France,2CERMES,Niamey,Niger3Received13March2003/Returnedformodification9May2003/Accepted20May2003 ABSTRACTTopAbstractTextReferencesWeevaluatedtherecentlydevelope...
醫源資料庫;在線期刊;微生物臨牀雜誌;2003年第41卷第8期CD44isadeterminantofinflammatoryboneloss
...mentalTraumaSurgery,UniversitySchoolofHamburg,D-20146Hamburg,Germany6BoehringerIngelheim,A-1121Vienna,Austria7ResearchInstituteofMolecularPathology,A-1030Vienna,AustriaChronicinflammationisamajortriggeroflocalandsystemicboneloss.Disintegrationofcell–matrixinteractionisaprerequisitefortheinvasionof...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第6期ATNFreceptorlooppeptidemimicblocksRANKligand-inducedsignaling,boneresorption,andboneloss
...niversitySchoolofMedicine,NewHaven,Connecticut,USA.2DepartmentofHardTissueEngineering,SectionofPharmacology,GraduateSchool,TokyoMedicalandDentalUniversity,Tokyo,Japan.3SuntoryInstituteforBioorganicResearch,Osaka,Japan.4DepartmentofPharmacology,TsurumiUniversity,SchoolofDentalMedicine,Yokohama,Japan....
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第6期