Regulationofthickascendinglimbtransport:roleofnitricoxide
...ecteffectsofnitricoxide(NO)onindividualtransportersofthethickascendinglimb(THAL)cell.NOdirectlyinhibitsNa+-K+-2Cl-cotransportandNa/Hexchangers(NHE1/3).NOinhibitstheNa+-K+-ATPasepumpbyreactingwithO2-andformingOONO-.TheeffectofNOoninwardlyrectified(ROMK)channelsremainscontroversial.(-),Inhibition;(?),...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第6期RenewalofMuralThrombusReleasesPlasmaMarkersandIsInvolvedinAorticAbdominalAneurysmEvolution
...emedia,andahigherlevelofimmuno-inflammationintheadventitia.6Thiscontrastswithalowerlevelofproteaseactivitieswithinthethrombus-exposedarterialwallascomparedwiththewallnotexposedtothrombusactivity.7Themuralthrombusisenrichedwithplasminogen-plasmin,3andfibrinolysispredominatesintheabluminalpartofthethr...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第3期MiceDeficientfortheTypeIITransmembraneSerineProteaseTMPRSS/hepsinExhibitProfoundHearingLoss
...eobtainedandstainedwithhematoxylinandeosin.Thecross-sectionalareaoftheRosenthal??scanal,osseousspirallamina,andtectorialmembranefromthemiddleturnweredeterminedusingamorphometricprogram(AxioVisionLE,Hallbergmoos,Germany).Thesameprogramwasalsousedtomeasurethelongestverticaldistancebetweenthedorsalandv...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第8期BK-1subunit:immunolocalizationinthemammalianconnectingtubuleanditsroleinthekaliureticresponsetovolumeexpansion
...l.(41)demonstratedflow-activatedeNOSandNOproductioninthethickascendinglimb(THAL).WeandothersshowedthatBKareactivatedbytheNO-cGMP-proteinkinaseGpathway(1,51,52)andthatthisactivationrequiresthepresenceofaBK-1orBK-2subunit(22,61).Weobservednearlyadoublingoftheopenprobability(PO)oncGMPadditioninanexpres...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第4期ImpairmentofFunctionalCapillaryDensitybutNotOxygenDeliveryintheHamsterWindowChamberduringSevereExperimentalMalaria
...ribundcomparedwithuninfectedcontrols,butthislevelwasmarkedlyhigherthanthelethalthreshold.Nonecroticcellslabeledwithpropidiumiodideweredetectedinmoribundanimalsonday10afterinfection.Wethereforeconcludethatlossoffunctionalcapillariesratherthantissuehypoxiaisamajorlethaleventinseveremalaria.-----------...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第2期PharmacologicalTargetingofAdipocytes/FatMetabolismforTreatmentofObesityandDiabetes
...persons.Additionalconsiderationstothetherapeuticuseofleptinaretherathershorthalf-lifeofthepeptideinhumans(25min)(Kleinetal.,1996),thehighcostofproduction,andtheneedforinjections,allfactsthatmaketheuseofleptinintheclinicproblematicforroutineusage.Theseconsiderationsalsoapplytoadiponectinandretinolbin...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第9期InhibitionofNa-K-ATPaseinthickascendinglimbsbyNOdependsonO2-andisdiminishedbyahigh-saltdiet
...nhancesnitricoxide(NO)-inducedinhibitionoftransportinthethickascendinglimb(THAL).LongexposurestoNOinhibitNa-K-ATPaseinculturedcells.WehypothesizedthatNOinhibitsTHALNa-K-ATPaseafterlongexposuresandahigh-saltdietwouldaugmentthiseffect.Ratsdrankeithertapwateror1%NaClfor7-10days.Na-K-ATPaseactivitywasas...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第8期SimplificationTherapywithOnce-DailyEmtricitabine,Didanosine,andEfavirenzinHIV-1InfectedAdultswithViralSuppressionReceivingaProteaseInhibitorB
...betweendosingintervalanddrughalf-life,andmissingadoseofamedicationwithashorthalf-lifeadministeredtwice-dailymayhavegreaterconsequencesthanmissingadoseofaonce-dailycombinationofdrugswithverylonghalf-lives,suchasthoseusedintheonce-dailyregimenassessedinthepresentstudy.Anotherpotentialconcernofthisonce...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第6期Microarray-BasedDetectionof90AntibioticResistanceGenesofGram-PositiveBacteria
...ntimicrob.AgentsChemother.45:2691-2694.Chow,J.W.,M.J.Zervos,S.A.Lerner,L.A.Thal,S.M.Donabedian,D.D.Jaworski,S.Tsai,K.J.Shaw,andD.B.Clewell.1997.AnovelgentamicinresistancegeneinEnterococcus.Antimicrob.AgentsChemother.41:511-514.Chung,W.O.,C.Werckenthin,S.Schwarz,andM.C.Roberts.1999.HostrangeoftheermF...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第5期DopaminergicneuronsgeneratedfrommonkeyembryonicstemcellsfunctioninaParkinsonprimatemodel
...othEGFandFGF-2.J.Neurosci.18::7869-7880.Kuhn,H.G.,Winkler,J.,Kempermann,G.,Thal,L.J.,andGage,F.H.1997..Epidermalgrowthfactorandfibroblastgrowthfactor-2havedifferenteffectsonneuralprogenitorsintheadultratbrain.J.Neurosci.17::5820-5829.Schuldiner,M.,Tanuka,O.,Itskovitz-Eldor,J.,Melton,D.A.,andBenvenis...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第1期