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VitaminB-12metabolisminHIV-infectedpatientsintheageofhighlyactiveantiretroviraltherapy:roleofhomocysteineinassessingvitaminB-12status
...antiretroviraltherapy(HAART),20%and10%ofHIV-infectedpatientshadlowvitaminB-12andredbloodcellfolate(RBCF)concentrations,respectively.However,fewpatientshadrealvitaminB-12deficiency.Objective:WeevaluatedtheprevalenceoflowvitaminB-12andRBCFconcentrationsinHIV-infectedpatientsreceivingHAARTandtheusefuln...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2003年77卷第2期 -
Ala12variantoftheperoxisomeproliferator-activatedreceptor-gene(PPARG)isassociatedwithhigherpolyunsaturatedfatinadiposetissueandattenuatest
...disease.Lessisknownaboutthegeneticvariationmodulatingthisassociation.TheAla12alleleoftheperoxisomeproliferator-activatedreceptor-gene(PPARG)decreasesthelipolysisoftriacylglycerolsinadiposetissue,whichresultsintheaccumulationoffattyacidsinadipocytes.Objective:WeaimedtodeterminewhetherthePro12Alapolym...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2007年86卷第4期 -
DomainsNecessaryforG12BindingandStimulationofProteinPhosphatase-2A(PP2A):IsG12aNovelRegulatorySubunitofPP2A?
...),awidelyexpressedserine/threoninephosphatase,andtheheterotrimericGproteinG12.PP2Aactivityisalteredincarcinogenesisandinsomeneurodegenerativediseases.WehaveidentifiedbindingofG12withtheAsubunitofPP2A,atrimericenzymecomposedofA(scaffolding),B(regulatory),andC(catalytic)subunitsanddemonstratedthatG12s...
醫源資料庫；在線期刊；分子藥理學雜誌；2007年第69卷第5期 -
VegetarianismandvitaminB-12(cobalamin)deficiency
...2),whosesustainedinvestigationsofclinicallyrelevantissuesrelatedtovitaminB-12,folate,andone-carbonmetabolismearnedhimrespect,admiration,andstatusasoneofthegiantsinthisfield.(Internet:http://www.victorherbert.com,accessed4March2003.)3SupportedbyNIHgrantsR01CA58919andR01HD39295andbyaVeteransAffairsMer...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2003年78卷第1期 -
TheEffectsofLeukocyte-Type12/15-LipoxygenaseonId3-MediatedVascularSmoothMuscleCellGrowth
...801394,Charlottesville,VA22908.E-mailcam8c@virginia.eduAbstractObjective—12/15-Lipoxygenase(12/15-LO)hasbeenimplicatedinthepathogenesisofvasculardisease.Vascularsmoothmusclecell(VSMC)proliferationisakeycomponentoftheresponsetoinjuryinvasculardisease.Theroleof12/15-LOinregulatingVSMCproliferationis...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2005年第25卷第10期 -
ProportionofindividualswithlowserumvitaminB-12concentrationswithoutmacrocytosisishigherinthepost–folicacidfortificationperiodthanin
...m.ABSTRACTBackground:LargeintakesoffolicacidmaydelaythediagnosisofvitaminB-12deficiency,whichcouldleadtoirreversibleneuropathy.Objective:TheobjectiveofthisstudywastodeterminewhethertheproportionofindividualswithlowserumvitaminB-12withoutmacrocytosis(undiagnosedvitaminB-12deficiency)hasincreasedinthe...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2007年86卷第4期 -
HSPA12BIsPredominantlyExpressedinEndothelialCellsandRequiredforAngiogenesis
【摘要】Objective-HSPA12BisthenewestmemberofHSP70familyofproteinsandisenrichedinatheroscleroticlesions.ThisstudyfocusedonHSPA12Bexpressioninmiceanditsinvolvementinangiogenesis.MethodsandResults-TheexpressionofHSPA12Binmiceandculturedcellswasstudiedby:(1)Northernblot;(2)insituhybridization;(3)imm...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2006年第26卷第9期 -
AssessingtheassociationbetweenvitaminB-12statusandcognitivefunctioninolderadults
...406.Itiswellestablishedthattheclinicalmanifestationsofovert,severevitaminB-12deficiencyincludebothhematologic(macrocyticormegaloblasticanemia)andneurologic(subacutecombineddegenerationofthespinalcord,peripheralneuropathy,cognitiveimpairment)sequelae.Theneurologicconsequencesareofparticularconcern,be...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2006年84卷第6期 -
白細胞介素12及其抗腫瘤作用
IL-12是新近發現的一種細胞因子，具有多種生物學活性，尤其是在抗腫瘤免疫和抗病毒免疫中有重要的作用。 一、IL-12概況 IL-12主要來源於單核/巨噬細胞、抗原遞呈細胞和B細胞，是由相對分子質量爲40×103和35×103兩個亞...
合作平臺；醫學論文；外科論文；普通外科學 -
EffectoforalvitaminB-12withorwithoutfolicacidoncognitivefunctioninolderpeoplewithmildvitaminB-12deficiency:arandomized,placebo-controll
...tQLK3-CT-2002-01775fromtheFoundationtoPromoteResearchIntoFunctionalVitaminB12DeficiencyandtheEuropeanUnionBIOMEDDemonstrationProject;andgrant2004-E2fromtheNutriciaHealthFoundation,Wageningen,Netherlands.3AddressreprintrequeststoLCdeGroot,DivisionofHumanNutrition,WageningenUniversity,POBox8129,6700EV...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2006年84卷第2期