HepaticexpressionofscavengerreceptorclassBtypeI(SR-BI)isapositiveregulatorofmacrophagereversecholesteroltransportinvivo
...sylvania,USA.AbstractHepaticexpressionofthescavengerreceptorclassBtypeI(SR-BI)promotesselectiveuptakeofHDLcholesterolbytheliverandisbelievedtoplayaroleintheprocessofreversecholesteroltransport(RCT).WehypothesizedthathepaticSR-BIexpressionisaregulatoroftherateofintegratedmacrophage-to-fecesRCTandused...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期RelativeContributionsofABCA1andSR-BItoCholesterolEffluxtoSerumFromFibroblastsandMacrophages
...tohumanserum.MethodsandResults-HumanfibroblastswerestablytransfectedwithSR-BIwhileABCA1wasupregulated.Quantitationofcholesteroleffluxtohumanserumdemonstratedthattherewaseffluxfromcellswithouteitherprotein.ExpressionofABCA1producedasmallincreaseinefflux,whereasSR-BIexpressionhadadramaticimpact.Toquan...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第3期Cholesterolbinding,efflux,andaPDZ-interactingdomainofscavengerreceptor–BImediateHDL-initiatedsignaling
...ia,Pennsylvania,USA.5DepartmentofMedicine,DivisionofMolecularMedicine,ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork,NewYork,USA.AbstractThebindingofHDLtoscavengerreceptor–BI(SR-BI)mediatescholesterolmovement.HDLalsoinducesmultiplecellularsignals,whichinendotheliumoccurthroughSR-BIandcon...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第4期DifferentialAdditiveEffectsofEndothelialLipaseandScavengerReceptor-ClassBTypeIonHigh-DensityLipoproteinMetabolisminKnockoutMouseModels
...crinologyandMetabolism(K.M.,L.C.),DepartmentsofMedicineandMolecularCellularBiology,BaylorCollegeofMedicine,andSt.Luke’sEpiscopalHospital,Houston,Tex;LawrenceBerkeleyNationalLaboratory(T.F.),Berkeley,Calif;andLipoScience(J.D.O.),Raleigh,NC.CorrespondencetoLawrenceChan,DivisionofEndocrinologyMetabol...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第1期CholesterylEsterTransferProtein(CETP)ExpressionProtectsAgainstDietInducedAtherosclerosisinSR-BIDeficientMice
...ssionofthehumanCETPtransgeneprotectsagainstdiet-inducedatherosclerosisinSR-BIdeficientmice.MethodsandResults-SR-BIdeficient(-/-)micewerecrossedwithCETPtransgenic(CETPtg)micetoproduceacolonyofSR-BI-/-xCETPtgmiceinaC57Bl/6background.Ageandsexmatchedgroupsofgeneticallymodifiedandwild-typeC57Bl/6micewer...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第4期MacrophageApolipoproteinEReducesAtherosclerosisandPreventsPrematureDeathinApolipoproteinEandScavengerReceptor-ClassBIDouble-KnockoutMice
...】Objective-Micenullforbothapolipoprotein(apo)Eandscavengerreceptor(SR)-BI(DKO)developseverehypercholesterolemia,occlusivecoronaryatherosclerosis,myocardialinfarction,andprematuredeath.ThecurrentstudyexaminestheabilityofmacrophageapoEtoimprovethedyslipidemia,reduceatherosclerosis,andrescuethelethal...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第1期HCV蛋白酶抑制劑BI201335有強效抗病毒活性
...林格殷格翰公司研發的丙肝病毒(HCV)NS3/4A蛋白酶抑制劑BI201335,在初治和經治的慢性基因1型丙肝病毒(HCV)感染患者中的優異療效。基因1型的HCV是在所有HCV感染治療中最有挑戰性的基因分型。 丙型肝炎是肝臟感染性疾病...
行業資訊;臨牀快報;肝膽病ScavengerReceptorClassBTypeIMediatestheSelectiveUptakeofHigh-DensityLipoprotein–AssociatedCholesterylEsterbytheLiverinMice
...H.G.,M.M.,F.R.),Hamburg,Germany;andtheCollegeofPhysiciansandSurgeonsofColumbiaUniversity(R.R.),NewYork,NY.CorrespondencetoDrFranzRinninger,UniversityHospitalHamburg-Eppendorf,DepartmentofMedicine,Martinistrasse52,20246Hamburg,Germany.E-mailRinninger@uke.uni-hamburg.deAbstractObjective—High-density...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第1期Bi-PAP呼吸機通氣治療慢性阻塞性肺疾病合併呼吸衰竭
【摘要】目的研究無創Bi-PAP呼吸機治療慢性阻塞性肺疾病(COPD)合併呼吸衰竭。方法52例患者隨機分爲治療組27例,持續Bi-PAP呼吸機治療;對照組25例,持續低流量吸氧。兩組同時抗感染等常規治療。觀察血氣和臨牀症狀變化。結...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2005年第3卷第9期IncreasedOxidativeStressinScavengerReceptorBIKnockoutMiceWithDysfunctionalHDL
【摘要】Objective—InthecurrentstudytheeffectofdisruptionofSR-BI,aprominentregulatorofHDLmetabolism,ontheactivityoftheHDL-associatedantioxidantenzymesPON1andPAF-AHaswellasinvivooxidativestresswereinvestigated.MethodsandResults—SR-BIdeficiencyresultedin1.4-fold(P0.001)and1.6-fold(P0.01...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第11期