Humanizedmice:arewethereyet
aF.M.isatDivisionofAllergy,Immunology,andTransplantation,NationalInstituteofAllergyandInfectiousDiseases,Bethesda,MD20892.bM.G.M.isatInstituteforResearchinBiomedicine,CH-6500Bellinzona,Switzerland.cA.K.P.isatBaylorInstituteforImmunologyResearch,Dallas,TX75204.dL.D.S.isatTheJacksonLaboratory,BarHarbo...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第10期Shorttermefficacyandsafetyinglaucomapatientschangedtothelatanoprost0.005%/timololmaleate0.5%fixedcombinationfrommonotherapiesandadjunctive
1Starnberg,Germany2Hildesheim,Germany3Berlin,Germany4Marbach,Germany5Gerolzhofen,Germany6Neustadt,Germany7Berchtesgaden,Germany8Jena,Germany9Biedenkopf,Germany10Donauw?rth,Germany11PharmaceuticalResearchNetwork,LLC,Charleston,SC,USA12CarolinaEyeInstituteattheUniversityofSouthCarolinaSchoolofMedicine...
醫源資料庫;在線期刊;英國眼科學雜誌;2004年第88卷第10期ProductionoftypeIinterferons:plasmacytoiddendriticcellsandbeyond
G.T.isattheLaboratoryforParasiticDiseases,NationalInstituteofAllergyandInfectiousDiseases,NationalInstitutesofHealth,Bethesda,MD20892.Plasmacytoiddendriticcells(pDCs)arespecializedproducersoftypeIinterferons(IFNs)thatrespondtomostviruses.Becauseoftheirantiviralactivityandregulatoryfunctionsininnatea...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第4期Thevery5‘endandtheconstantregionofIggenesaresparedfromsomaticmutationbecauseAIDdoesnotaccesstheseregions
...mmunology,UniversityofChicago,Chicago,IL606372DepartmentofMolecularGeneticsandCellBiology,UniversityofChicago,Chicago,IL606373DepartmentofStatistics,UniversityofChicago,Chicago,IL60637Somatichypermutation(SHM)isrestrictedtoVDJregionsandtheiradjacentflanksinimmunoglobulin(Ig)genes,whereasconstantregi...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第10期模式生物---小鼠的介紹
...edstrain): 1)BALB/c小鼠 形成了許多亞系,如BALB/cAnN,BALB/cJ,BALB/cCd。BALB/c小鼠基因型爲Aa***c。毛色爲白色。其乳腺癌發病率低,但對致癌因子敏感。乳腺腫瘤發生率約爲10﹪~20﹪。有一定數量的卵巢、腎上腺和肺部腫瘤、...
醫藥經濟;生物技術;實驗技術;動物學技術Pharmacologyof-ConotoxinMII-SensitiveSubtypesofNicotinicAcetylcholineReceptorsIsolatedbyBreedingofNullMutantMice
...o30%ofthepresynapticnAChRsexpressedinstriataldopaminergicterminalsinrodentsand70%inmonkeys.Thisclassofreceptors,potentiallyimportantinnicotineaddiction,binds-conotoxinMII(-CtxMII)withhighaffinityandisheterogeneous,consistingofseveralsubtypesinmice,possiblyanimportantconsiderationforthedesignofcompou...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第6期C型肝炎增加非何傑金氏淋巴瘤風險
...與休士頓MichaelE.DeBakey退伍軍人事務醫學中心,由ThomasGiordano醫師所領導的團隊於5月9日的美國醫學會期刊(JAMA)中表示,我們的研究顯示,在5年的後續追蹤中,感染之後會發展出這些結果,且感染C型肝炎病毒病患的風險持續上...
行業資訊;臨牀快報;肝膽病DetectionofPseudomonasaeruginosaProducingMetallo--LactamasesinaLargeCentralizedLaboratory
DivisionofMicrobiology,CalgaryLaboratoryServicesDepartmentsofPathologyandLaboratoryMedicineMedicine,UniversityofCalgary,Calgary,Alberta,CanadaServicedeBacteriologie-Virologie,HpitaldeBicêtre,AssistancePublique/HpitauxdeParis,FacultedeMedecineParis-Sud,94275LeKremlin-Bicêtre,FranceABSTRACTMetallo--...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期TheimmunophilinFKBP52inhibitstheactivityoftheepithelialCa2+channelTRPV
【摘要】Inthekidney,theepithelialCa2+channelTRPV5constitutestheapicalentrypathwayintheprocessofactiveCa2+reabsorption.TheregulationofCa2+influxthroughTRPV5isofcrucialimportance,becauseitdeterminesthefinalamountofCa2+excretedintheurine.ThepresentstudyidentifiesFKBP52asanauxiliaryproteinofTRPV5,in...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第5期AutoantibodiesmakeaU-turn:thetollhypothesisforautoantibodyspecificity
aD.A.M.andK.B.E.areattheDepartmentofMedicine,UniversityofWashington,Seattle,WA98195.bK.B.E.isattheDepartmentofImmunology,UniversityofWashington,Seattle,WA98195.Liketheimmuneresponseitself,oureffortstounderstandthe“rules“forself–nonselfdiscriminationareconstantlyevolving.Thediscoveryofpatternre...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第11期