ATNFreceptorlooppeptidemimicblocksRANKligand-inducedsignaling,boneresorption,andboneloss
...niversitySchoolofMedicine,NewHaven,Connecticut,USA.2DepartmentofHardTissueEngineering,SectionofPharmacology,GraduateSchool,TokyoMedicalandDentalUniversity,Tokyo,Japan.3SuntoryInstituteforBioorganicResearch,Osaka,Japan.4DepartmentofPharmacology,TsurumiUniversity,SchoolofDentalMedicine,Yokohama,Japan....
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第6期Highprevalenceoflowdietarycalcium,highphytateconsumption,andvitaminDdeficiencyinhealthysouthIndians
...bansubjects(P0.001),bothmenandwomen.Intheruralsubjects,25(OH)D-deficient(20ng/mL),-insufficient(2030ng/mL),and-sufficient(30ng/mL)stateswereobservedin44%,39.5%,and16.5%ofthemenand70%,29%,and1%ofthewomen,respectively.Intheurbansubjects,25(OH)D-deficient,-insufficient,and-sufficientstateswereobs...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第4期經直腸超聲研究移行區體積校正的前列腺特異性抗原濃度在前列腺癌診斷中的意義
...列腺特異性抗原(PSA)正常的前列腺增生,第2組爲PSA>10.0ng/ml的良性前列腺增生,第3組爲4.0ng/ml<PSA≤10.0ng/ml的前列腺癌。經直腸超聲測量前列腺體積和前列腺移行區體積對PSA進行校正,計算前列腺特異性抗原濃度(PSAD)和PSATZ,觀...
行業資訊;臨牀快報;檢驗與超聲影像周炎患牙齦溝液中IL-10和IFN-Y的含量測定
...員研究顯示,活動期患牙組齦溝液中IFN-γ的濃度(14.25±2.35ng/ml)顯著高於靜止期患牙組(4.36±0.41ng/ml,p<0.05),活動期患牙組齦溝液中IL-10的濃度(3.64±0.56ng/ml)顯著低於靜止期患牙組(11.26±3.05ng/ml,p<0.05)。因此可見作爲Th1家族的細...
行業資訊;臨牀快報;口腔科InfluenceofenvironmentaltobaccosmokeonvitaminCstatusinchildren
...minCstatusofnonsmokerswhoareexposedtoenvironmentaltobaccosmoke(ETS)isnowbeingelucidated.Objective:WeassessedvitaminCstatusinchildrenwhowereeitherexposedornotexposedtoETS,andwesoughttoassociatechangesinvitaminCstatuswiththeamountofETSexposure.Design:Thestudygroupincluded512childrenaged212y;50%o...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年77卷第1期PossibleRegulationofMigrationofIntrahepaticCholangiocarcinomaCellsbyInteractionofCXCRExpressedinCarcinomaCellswithTumorNecrosisFactor-and
【摘要】Intrahepaticcholangiocarcinoma(ICC)ishighlyfatalbecauseofearlyinvasion,widespreadmetastasis,andlackofaneffectivetherapy.WeexaminedrolesofCXCR4anditsligand,stromalcell-derivedfactor(SDF)-1,inmigrationofICCwithrespecttotumor-stromalinteractionbyusingtwoICCcelllines,afibroblastcellline(WI-3...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第4期BacterialPeptidoglycan-AssociatedLipoprotein:ANaturallyOccurringToll-LikeReceptor2AgonistThatIsShedintoSerumandHasSynergywithLipopolysaccha
...animals.WeexploredtheinflammatoryeffectsofpurifiedPALandofanaturallyoccurringformofPALthatisshedintoserum.PALisreleasedintohumanserumbyEscherichiacolibacteriainaformthatinducescytokineproductionbymacrophagesandistightlyassociatedwithlipopolysaccharide(LPS).PALactivatesinflammationthroughTLR2.PALandL...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第6期AcuteregulationofOAT3-mediatedestronesulfatetransportinisolatedrabbitrenalproximaltubules
...niontransport.Incontrast,epidermalgrowthfactor(EGF)increasedESuptakefollowingactivationofMAPK.ExposuretoPGE2ordibutyryl(db)-cAMPalsoenhancedESuptake.StimulationproducedbyPGE2anddb-cAMPwaspreventedbythePKAinhibitorH-89,indicatingthatthisstimulationrequiredPKAactivation.Inaddition,inhibitionofcyclooxy...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第11期HumanScalpHairFolliclesAreBothaTargetandaSourceofProlactinwhichServesasanAutocrineand/orParacrinePromoterofApoptosis-DrivenHairFollicl
...yofbioregulatoryeffectsinmammalsandisalsofoundinextrapituitarysites,includingmurineskin.Here,weshowbyreversetranscriptase-polymerasechainreactionandimmunohistologythat,contrarytoapreviousreport,humanskinandnormalhumanscalphairfollicles(HFs),inparticular,expressbothPRLandPRLreceptors(PRL-R)atthemRNAa...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第3期柱前衍生化高效液相色譜法拆分人體血漿和尿液中阿替洛爾對映體的研究
...R(+)-阿替洛爾對映體血、尿樣品的線性範圍分別爲10~1000ng/mL和25~1500ng/mL,絕對回收率均在84%以上,RSD均小於6.0%。此法已經用於阿替洛爾對映體的藥代動力學和藥效學研究。 關鍵詞:阿替洛爾對映體高效液相色譜法衍生化...
藥品天地;專業藥學;實驗技術;色譜技術;色譜分析實例