高血壓小劑量聯合用藥現狀與評價

...合用藥降壓效果（略）　　注:+（有效），-（負效應），GFR（腎小球濾過率），LVH（左室肥厚），D（利尿劑），βB（β受體阻滯劑），ACE（I血管緊張素轉換酶抑制劑），C（鈣拮抗劑），αB（α受體阻滯劑）　　參考文獻　　1劉...

AsymmetricDimethylarginineEnhancesCardiovascularRiskPredictioninPatientsWithChronicHeartFailure

...ficientsofvariationwere<4.5%and<6.5%,respectively.Glomerularfiltrationrate(GFR)wasestimatedfromserumcreatinineaccordingtotheModificationofDietinRenalDiseaseStudyequation.22StudyEndPointsThecompositeclinicalendpointwasdefinedastheoccurrenceofcardiacdecompensation,majoradversecardiovascularevents(MACE...

Overexpressionofkidneyneutralendopeptidase(EC3.4.24.11)andrenalfunctioninexperimentalcirrhosis

...0.025ml·kg-1·h-1PAHfor150mintoassessglomerularfiltrationrate(GFR)andrenalplasmaflow(RPF)atdifferenttimesbymeansoftheirrespectivesteady-stateplasmaclearances(CInandCPAH)(10,30).After90minofinulinplusPAHinfusion(i.e.,oncetheirsteady-stateplasmaconcentrationswerereached)(10),alaparotomywa...

EvaluationoftheRapidImmunoassayDetermineHIV1/2forDetectionofAntibodiestoHumanImmunodeficiencyVirusTypes1and2

...ologicalstatus.Allfourrapidtestsshowed100%sensitivityandspecificitiesrangingfrom99.4to100%:DetermineHIV1/2,99.4%;HIVSPOT,99.6%,Capillus,99.7%;andGenieII,100%.Thepatientwiththefalse-negativeRTresultturnedouttohaveend-stageAIDS.TheRTapparentlylackssufficientantigenicdeterminantstodetectallpatientswith...

EnhancedExpressionofKeratinocyteGrowthFactorandItsReceptorCorrelateswithVenousInvasioninPancreaticCancer

【摘要】Keratinocytegrowthfactor(KGF)andKGFreceptor(KGFR)havebeenimplicatedincancergrowthaswellastissuedevelopmentandrepair.Inthisstudy,weexaminedwhetherKGFandKGFRhavearoleinhumanpancreaticductaladenocarcinoma(PDAC).KGFRmRNAwasexpressedineightpancreaticcancercelllines,whereastheKGFmRNAwasdetecte...

LossofSPARC-mediatedVEGFR-1suppressionafterinjuryrevealsanovelantiangiogenicactivityofVEGF-A

...essedbyVEGF-Aafterinjury.ThisunorthodoxantiangiogeniceffectwasmediatedviaVEGFR-1activationandVEGFR-2deactivation,thelatterviaSrchomologydomain2–containing(SH2-containing)tyrosinephosphatase-1(SHP-1).TheVEGFR-1–specificligandplacentalgrowthfactor-1(PlGF-1),butnotVEGF-E,whichselectivelybindsVEGFR-...

血管緊張素轉化酶抑制劑和血管緊張素受體阻滯劑的比較和選用

...抑制劑主要作用於出球小動脈，因而降低腎小球濾過率（GFR）的作用比較明顯，而ARBs可均衡地擴張入球小動脈和出球小動脈，對GFR的影響比較輕微。腎功不全患者服用ARBs發生高鉀血癥者比ACE抑制劑輕微。儘管兩類藥物藥理作用...

第四節　連續性動-靜脈血液濾過

...μmol/L（6.0mg/dl），此相互關係與血肌酐和腎小球濾過率（GFR）的相互關係相似。　　Olbricht報告一組30例病人，每日超濾量14.2±4.6L，血清肌酐穩定在500μmol/L以下，平均血清尿素爲38mmol/L。但在另一組病例，病人每日超濾量爲9.9±3....

TPreceptorsregulaterenalhemodynamicsduringangiotensinIIslowpressorresponse

...lockadeofTP-/-miceinfusedwithANGII.Figure2showstheglomerularfiltrationrate(GFR),renalbloodflow(RBF),FF,andRVRinTP+/+andTP-/-miceafter12-14daysofVehorANGIIinfusion.TP-/-micehadlowerbaselineRBF(P<0.001)andhigherFFandRVR(FF:P<0.01,RVR:P<0.001)thanTP+/+mice.TherewasasignificantinteractionbetweenTP-Rsand...

Upregulationofmaculadensacyclooxygenase-2expressionisnotdependentonglomerularfiltration

...entheligatedandtheunligatedkidney[NKCC2expression,glomerularfiltrationrate(GFR)]wereanalyzedbyStudent‘spairedt-test.Comparisonsbetweenthecontrolgroupandthelow-saltorthefurosemidegroup(COX-2mRNA,reninmRNA,PRA)weremadebyANOVAandBonferroniadjustmentformultipletesting.Pvalues<0.05wereconsideredstatist...