CurcuminInhibitsHypoxia-InducibleFactor-1byDegradingArylHydrocarbonReceptorNuclearTranslocator:AMechanismofTumorGrowthInhibition
...lfoximine;-gal,-galactoside;HA,hemagglutinin;MG132,N-benzoyloxycarbonyl(Z)-Leu-Leu-leucinal;Z-VAD-FMK,Z-Val-Ala-Asp(OMe)-fluoromethylketone.【參考文獻】AggarwalBB,KumarA,andBhartiAC(2003)Anticancerpotentialofcurcumin:preclinicalandclinicalstudies.AnticancerRes23:363-398.[Medline]ArbiserJL,Klau...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第11期二、細胞因子受體中的共用鏈
...200pM 1個HCSF結構域(GPI錨) 注:(1)LIF:leukaemiainhibitoryfactor;OSM:oncostatinM;CNTF:ciliaryneurotrophicfactor. (2)IGSF:immunoglobulinsuperfamily;GCRF:hematopoieticcytokinereceptorfamily. (3)gp130轉導IL-6、IL-11刺激信號,gp130與LIFR兩種鏈轉...
醫源資料庫;醫源圖書館;教材類;細胞和分子免疫學RegulationofSerumResponseFactor-DependentGeneExpressionbyProteasomeInhibitors
...nhibitionofproteasome-dependentproteindegradationbyN-benzoyloxycarbonyl(Z)-Leu-Leu-leucinal(MG132)orlactacystin(LC)didnotenhancethelevelsofSMA,but,unexpectedly,attenuatedSMAexpressioninresponsetoET1,withoutaffectingtheviabilityofVSMCs.Down-regulationofSMAproteinbyMG132orLCoccurredatthelevelofSMAtran...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期第四節 脂代謝有關酶類與特殊蛋白質
...,是維持其活性必不可少的組分,富含Glu、Asp、Gly、Pro、Leu。每一酶分子含4個Cys,其中兩個連成二硫鍵。根據與胰脂酶序列的同源性比較,推測六肽Ⅰ178-G-H-S-L-G183可能是酶的活性中心。酶蛋白的α螺旋、β-摺疊和其他結構比例...
醫源資料庫;醫源圖書館;教材類;臨牀生物化學GeneticDeterminantsofArterialThrombosis
...genisanacute-phasereactant,inpartowingtoitsupregulationviaactivationofinterleukin-6–responsiveelementsinthepromoterofall3fibrinogenchains;theacute-phaseresponsearisingfromviralinfection,inflammatorystimuli,andsmokinginparticularisstronglyimplicatedinthedevelopmentofarterialdisease.Alternatively,el...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第2期QuercetinActivatesanAngiogenicPathway,HypoxiaInducibleFactor(HIF)-1-VascularEndothelialGrowthFactor,byInhibitingHIF-ProlylHydroxylase:aStruct
...lated;ELISA,enzyme-linkedimmunosorbentassay;MG-132,N-benzoyloxycarbonyl(Z)-Leu-Leu-leucinal.Theonlineversionofthisarticle(availableathttp://molpharm.aspetjournals.org)containssupplementalmaterial.【參考文獻】AgulloG,Gamet-PayrastreL,ManentiS,VialaC,RemesyC,ChapH,andPayrastreB(1997)Relationship...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第6期第二節 血清鹼性蛋白
...47Thr5.1674.97Ala7.54108.211Val5.2374.86Met1.5921.52Ile3.6152.74Leu8.03106.28Phe3.6153.24His2.9541.42Lys6.7595.27Pro5.0265.27TrpND ND 殘基總數129 135 分子量14335Da 14514Da 等電點9.10 9.10 氨基酸組成分析也證實BPⅠ和ASP都含有豐富的...
醫源資料庫;醫源圖書館;教材類;動脈粥樣硬化BafilomycinInducesthep21-MediatedGrowthInhibitionofCancerCellsunderHypoxicConditionsbyExpressingHypoxia-InducibleFactor-1
...linemedia(Fig.2D).Aftertreatmentofbafilomycin,pVHLwasnotsequesteredtothenucleus,whereasHIF-1waspresentspecificallyinthenucleus(Fig.2E).Moreover,anacridineorangestainingshowedthatendosomalpHwasnotchangedby4-htreatmentwith10nMBM(SupplementalResultS1).TheseresultssuggestthattheHIF-1stabilizationbybafil...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期毛細管電泳和基體輔助激光解吸/電離飛行時間質譜聯用技術研究進展
...採用248nm的紫外激光獲得了色胺、5-羥基色胺和一些肽(Val-Leu、Phy-Gly、Val-Phe)的CE-MALDI-TOFMS分析結果。同時討論了CE陽極室壓力、CE流速、鹼金屬離子(Na+、K+)對分析結果的影響。圖3CE-MALDI-TOFMS示意圖1-真空泵,2-CE高壓電源,3-毛細管...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文IdentificationofaNovelLigandBindingResidueArg38(1.35)intheHumanGonadotropin-ReleasingHormoneReceptor
...onsequentreceptoractivation.Materials.GnRHI(pGlu1-His2-Trp3-Ser4-Tyr5-Gly6-Leu7-Arg8-Pro9-Gly10-NH2)andGnRHII([His5,Trp7,Tyr8]GnRH)werepurchasedfromSigma(St.Louis,MO)andBachem(Bubendorf,Switzerland).Cetrorelix(Ac-D-Nap-Ala1-D-ClPh-Ala2-D-Pyr-Ala3-Ser4-Tyr5-D-Cit6-Leu7-Arg8-Pro9-D-Ala10-NH2),[Pro9-NH...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第1期