PotentiationofP2YReceptorsbyPhysiologicalElevationsofExtracellularK+viaaMechanismIndependentofCa2+Influx
...555:61eC70,2004].However,electrophysiologicalrecordingsof1321-N1cellsandmegakaryocytesdemonstratedthatK+alsoamplifiesADP-evokedCa2+responsesindependentlyofchangesinmembranepotential.ElevatedK+alsoamplifiedendogenousUTP-dependentCa2+responsesinhumanembryonickidney293cells,suggestingthatotherP2Yrecept...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期AdrenomedullinIsaCross-TalkMoleculethatRegulatesTumorandMastCellFunctionduringHumanCarcinogenesis
...ePCRbyincreasingtemperaturefrom50to96??C(0.5??Cincrements).Adefinedsinglepeakwasobtainedforallamplicons,thusconfirmingthespecificityoftheamplification.IsolationofMCsfromRatPeritoneumorCulturedfromHumanPeripheralBloodRatperitonealMCswerepreparedaccordingtoourpreviouslyestablishedprotocolunderapproved...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第1期NeurochemicalCharacterizationofaNeuroprotectiveCompoundfromParawixiabistriataSpiderVenomThatInhibitsSynaptosomalUptakeofGABAandGlycine
...venomandaninvestigationofitsmodeofaction.FrPbAIIinhibitssynaptosomalGABAuptakeinadose-dependentmannerandprobablydoesnotactonNa+,K+,andCa2+channels,GABABreceptors,or-aminobutyrate:-ketoglutarateaminotransferaseenzyme;therefore,itisnotdirectlydependentonthesestructuresforitsaction.DirectincreaseofGABA...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期DifferentialErbBSignalinginSquamousCellversusBasalCellCarcinomaoftheSkin
...comparedwiththeotherligands.Consistently,downstreamErbB1effectors(Erk1/2andAkt)wereactivatedintumorcellsofSCCbutnotofBCCandinadjacentepidermisofbothBCCandSCC.TheseresultsdemonstratethatErbB1signalingishyperactiveintumorcellsofSCCbutnotofBCCandinnearbyasymptomaticepidermisofbothtumortypes.Ourresultss...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第6期InadequacyoftheJanusKinase2/SignalTransducerandActivatorofTranscriptionSignalTransductionPathwaytoMediateEpisodicGrowthHormone-DependentReg
...atepisodicgrowthhormoneeffectsaremediatedbytheactivationoftheJanuskinase2(Jak2)/signaltransducerandactivatoroftranscription(Stat)5Bsignaltransductionpathway.Weobservedthatrestorationofthenormalmasculineplasmagrowthhormonepulseinhypophysectomizedmaleratsdidindeedrapidlyactivate(phosphorylate)Jak2,sho...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期Inhibitionofplatelet-derivedgrowthfactorsignalingattenuatespulmonaryfibrosis
...dose(100mg/kg)wasadministeredtoC57BL/6mice.TheplasmalevelsofSU9518rosetoapeakwithin2hofadministrationanddecayedslowlyoverthenextseveraldayswithahalf-lifeof73.6h(Fig.2A).ThiswasinagreementwithourpreviousresultsshowingthatSU9518isapotentinhibitorofbothPDGFRandPDGFRtyrosinekinases,andthatithadalongdura...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第6期RegulationofTRPV5andTRPV6byassociatedproteins
...ls(26,64,65).Third,TRPV5andTRPV6are100timesmoreselectiveforCa2+thanforNa+,makingtheepithelialCa2+channelsthemostCa2+-selectivemembersoftheTRPsuperfamily(65).Inaphysiologicalcontext,thispropertyrendersthesechannelsparticularlysuitedtotransportCa2+inthepresenceofNa+.Fig.2.PredictedtopologyofTRPV5/6inc...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第6期Chloridechanneldiseasesresultingfromimpairedtransepithelialtransportorvesicularfunction
...ersmaycontributetotherelativelyhighcytoplasmiciinepithelia,mostprominentlyNaK2Clcotransporters.OpeningofepithelialCl–channelswillthereforeleadmostlytoaneffluxofCl–,andthelocalizationofthesechannelswilldeterminethetransportdirection(Figure1).Hence,apicalCl–channelsareinvolvedinCl–secretion(as...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第8期VitaminK3(Menadione)-InducedOncosisAssociatedwithKeratin8PhosphorylationandHistoneH3Arylation
...iduewithinH3,exposedonlyintheopenchromatinoftranscriptionallyactivegenes,asaK3arylationtarget.ThesefindingsdelineatenewpathwaysassociatedwithK3-inducedstressandsuggestapotentiallynovelroleforH3Cys110asanuclearstresssensor.Quinonesencompassabroadarrayofbiologicallyactivecompoundsfoundbothendogenously...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第3期-wProtectsHippocampusduringExperimentalStatusEpilepticus
...eizure-inducedneuronaldeath.Statusepilepticuswasevokedinmicebyintra-amygdalakainicacid,causingcytochromecrelease,processingofcaspases9and7,anddeathofipsilateralhippocampalpyramidalneurons.SeizurescausedarapiddeclineinhippocampalBcl-wlevelsnotseenforeitherBcl-2orBcl-xl.TotestwhetherendogenousBcl-wwas...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第10期