Aroleforfungal-glucansandtheirreceptorDectin-1intheinductionofautoimmunearthritisingeneticallysusceptiblemice
...ionandactivationofarthritogenicTcells.Inthispaper,wehaveaddressedthisissuebyusinganewlyestablishedanimalmodelofRA.SKGmicespontaneouslydevelopTcell–mediatedchronicautoimmunearthritisasaconsequenceofamutationofthegeneencodinganSH2domainofZAP-70,akeysignaltransductionmoleculeinTcells(8).Thismutationi...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第6期AnantagonistpeptidemediatespositiveselectionandCD4lineagecommitmentofMHCclassII–restrictedTcellsintheabsenceofCD4
...oducesasemidiverserepertoireofCD4+Tcells.Immunity.7:209–219.Wiest,D.L.,L.Yuan,J.Jefferson,P.Benveniste,M.Tsokos,R.D.Klausner,L.H.Glimcher,L.E.Samelson,andA.Singer.1993.RegulationofTcellreceptorexpressioninimmatureCD4+CD8+thymocytesbyp56lcktyrosinekinase:basisfordifferentialsignalingbyCD4andCD8inim...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第1期圜(yuá,音圓)直
圜(yuá,音圓)直 人體部位名。指人中溝部位。《靈樞·五色》:“男子色在於面王,爲小腹痛,下爲卵痛,其圜直爲莖痛。”李念莪注:“圜直,指人中水溝穴也。人中有邊圜而直者,故人中色見,主陰莖作痛。”作者:
醫源資料庫;中醫詞典;字母YPPAR:adaggerintheheartofthemetabolicsyndrome
...PARinthetreatmentofmetabolicdisease.PPARenhancesfattyacidcatabolismandenergyuncouplinginadiposetissueandmuscle,anditsuppressesmacrophage-derivedinflammation.Itscombinedactivitiesintheseandothertissuesmakeitamultifacetedtherapeutictargetforthemetabolicsyndromewiththepotentialtocontrolweightgain,enhan...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期互聯網醫療的病誰能治
...做全平臺電商,自然不能放過藥品。盈利模式。盈利模式一直是互聯網醫療的痛點。春雨最早的概念是輕問診,後來是空中診所,現在則是準備接入病歷管理轉爲長期服務的私人醫生。在春雨依靠保險、線下診所聯營等其他盈利...
醫藥經濟;生物技術;技術要聞BiologicalbasisforthecardiovascularconsequencesofCOX-2inhibition:therapeuticchallengesandopportunities
...lNSAIDs(tNSAIDs)andselectiveinhibitorsofCOX-2andwhichareamongthemostcommonlyuseddrugs(5),relievepainandinflammationbysuppressingtheCOXfunctionofPGHSandtheconsequentformationofPGE2(6)andprostacyclin(PGI2)(7),butperhapsalsoofotherprostanoids.ThefailureofNSAIDstoinhibitPGHSHOX–dependentfreeradicalfor...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第1期色譜指紋圖譜指數F和相對指數Fr的研究
...ndexFrofChromatographicFingerprintsSUNGuo-xiang,LIUXiao-ling,DENGXiang-yu,SUNYu-qing,BIKai-shun(Collegeofpharmacy,ShenyangPharmaceuticalUniversity,Shenyang110016,China)ABSTRACT:AIMTheIndexFandrelativeIndexFrofChromatographicFingerprintswerefirstlyproposedtoindicatehowbountifulwastheinfor...
藥品天地;專業藥學;中藥大全;中藥指紋圖譜[華西都市報]醫療隊堅守25天
...醫療隊駐耿達鄉5人小分隊的隊長。沒人進來我們就堅決不走地震發生後不久,醫院發出通知徵集去災區救援的醫生。許潔立即報了名。根據安排,這20名醫護人員組成的醫療隊被“空投”到汶川4個不通公路的“孤島”:草坡鎮...
醫學教育;校園動態;上海交通大學醫學院AdvancesintheresearchoftransgenicmousemodelofHepatitisB
...first,foreigngenesareinjecteddirectlyintofertilizedeggsoflaboratoryanimalsbyusingmicroscopicoperatingsystemandmicroinjectiontechnology.Next,thefertilizedeggswiththeforeigngenesinsertedaretransplantedintotheuterusofthedonoranimalsthroughtheembryotransfertechnology.Andweneedtowaittillitturnsintotransg...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2008年第8卷第9期RapidandstronghumanCD8+Tcellresponsestovaccinationwithpeptide,IFA,andCpGoligodeoxynucleotide7909
...itionofCpGODNstomelanomaantigenA26–35peptide(Melan-A26–35peptide;awidelyusedantigenicpeptideinvaccinetrialsofHLA-A2+melanomapatients)mixedwithincompleteFreund’sadjuvant(IFA)increasedMelan-A-–specificTcellresponsesinHLA-A2transgenicmice(15).However,theCpGmotifsthatstimulatethemurineimmunesyst...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第3期