質譜沙龍第十三期活動報道
...:無法區分某些氨基酸,如Asn/Glu-Gln,Thr/Ser,Gly/Ala,Iie/Leu,柱後衍生的溫度比較高,檢測時間較長。在新生兒篩查中,可通過測定十幾種氨基酸對新生兒進行評價。還有一種CIL的同位素內標記物來檢測。iTRAQ試劑標記流程李老...
醫學教育;學術活動IndependentMechanisticInhibitionofCdc25PhosphatasesbyaNaturalProductCaulibugulone
...dingtheprotocolsandresourcesusedintheexperimentswiththetetracycline-inducibleU2OScellsexpressingHA-Cdc25B3.WethankPallaviBansalforassistancewithaspectsoftheseexperiments.ABBREVIATIONS:Cdk,cyclin-dependentkinase;ATM,ataxiatelangiectasiamutated;ATR,ATMandRad-3related;VHR,vacciniaH1-relatedphosphatase;...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期羥基喜樹鹼與ECF方案術前輔助化療治療中晚期胃癌近期療效觀察
...療效,產生協同作用[7]。ECF方案(Epirubicin、Cisplatin、Leuˉcororin、5-Fluorouracil)治療晚期胃癌由Cunningˉham[8]於1991年首先報道,此後Findlay等[9]、Welb等[10]相繼報道有效率在45%~71%之間;而時氏報道[11]羥基喜樹鹼加ECF方...
資料庫;在線期刊;中華現代內科學雜誌;2004年第1卷第4期GenomewideLinkageAnalysisIdentifiesNovelGeneticLociforLungFunctioninMice
...polymorphismsinexon2betweenthetwoparentalstrainsC3H/HeJandJF1/Msf:Thr86Met,Leu98Pro,Leu109Phe,andVal173Ileu.Summarizingtheresultsofthewholegenomescanforlungfunctionparameters,significantlinkagestolungsizeweredetectedonchromosomes15and17;todeadspacevolumeonchromosomes5and15;tolungcomplianceonchromoso...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第4期OxidativeEnzymopathiesandVascularDisease
...bolizedby5-lipoxygenase(5-LO)inthepresenceofitsaccessoryprotein(FLAP)toformleukotrienes(LTs).AAisalsometabolizedbythecyclooxygenasestoformmembersofanotherfamilyofinflammatorymediators,theprostaglandins(PGs).MitochondriaalsogeneratesuperoxideaselectronsaretransferredfromcomplexItocomplexIVduringnorma...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第7期二、免疫細胞中的凋謝
...fTh1andTh2responses.ImmunolToday,1991;12:A49 8.NittaT,etal.CD56(NKH-1/Leu19antigen)asanadhesionmoleculeinnaturalkiller-targetcellinteraction.JExp,Med,1989;170;1757 9.RitzJ,etal.Characterizationoffunctionalsurfacestructuresonhumannaturalkillercells.AdvancesinImmunology,1988;42:181 10.R...
醫源資料庫;醫源圖書館;教材類;細胞和分子免疫學6-5溶酶體與過氧化物酶體
...酶體,引導蛋白質進入過氧化物酶體的信號序列是-Ser-Lys-Leu-COO-。但對於過氧化物酶體膜上與蛋白輸入有關的受體和轉位因子瞭解甚少,至少和23種被稱爲peroxin的蛋白有關,其機理顯著不同於線粒體和葉綠體的蛋白轉運,如受體P...
醫源資料庫;醫源圖書館;教材類;細胞生物學PharmacologicalDifferencesbetweenHumanandGuineaPigHistamineH1Receptors:Asn84(2.61)asKeyResiduewithinanAdditionalBindingPocketintheH1Rec
...etherlands(M.B.,A.J.,F.v.d.M.,R.A.B.,R.L.)UCBS.A.PharmaSector,Braine-l‘Alleud,Belgium(M.G.,P.C.)AbstractWetestedseveralhistamineH1receptor(H1R)andantagonistsfortheirdifferencesinagonistsbindingaffinitiesbetweenhumanandguineapigH1RstransientlyexpressedinAfricangreenmonkeykidney(COS-7)cells.Especial...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第4期InVitroandinVivoNuclearFactor-BInhibitoryEffectsoftheCell-PenetratingPenetratinPeptide
...creaticedema),intrapancreaticconcentrationsofproinflammatorycytokines[interleukin(IL)-1,IL-6,andtumornecrosisfactor(TNF)-],activityofneutrophil-derivedmyeloperoxidase(asthemarkerofneutrophilsequestration),andotherparametersofthepancreatitis-associatedoxidativestress(reducedglutathione,malondialdehyd...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期TheArylHydrocarbonReceptorPredisposesHepatocytestoFas-MediatedApoptosis
...tal.,1994;Schmidtetal.,1996).Uponligandbinding,theAhRtranslocatesintothenucleus,dimerizeswithArnt,andbindstospecificDNAelementscalleddioxin-orxenobiotic-responseelementsupstreamofAhR-regulatedgenes,drivingtheirexpression.Inthisreport,wepresentevidencesuggestingthattheAhRpromotesFas-mediatedapoptosis...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第3期