EnhancingcGMPinexperimentalprogressiverenalfibrosis:solubleguanylatecyclasestimulationvs.phosphodiesteraseinhibition
...ny2DepartmentofPediatrics,SecondUniversityHospital,SunYat-senUniversity,Guangzhou,People’sRepublicofChina3DepartmentofCellBiologyandInstituteofNephrology,NiigataUniversityGraduateSchoolofMedicalandDentalSciences,Niigata,JapanABSTRACTcGMPservesasthemainsecondmessengerofnitricoxide(NO).Antifibrotice...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第1期Signalsforstresserythropoiesisareintegratedviaanerythropoietinreceptor–phosphotyrosine-343–Stat5axis
...resentstudiesrevealthat,unlikesteady-stateerythropoiesis,erythropoiesisduringanemiadependssharplyonanEporeceptor–phosphotyrosine-343–Stat5signalingaxis.Inmiceexpressingaphosphotyrosine-null(PY-null)Eporeceptorallele(EpoR-HM),severeandpersistentanemiawasinducedbyhemolysisor5-fluorouracil.Inshort-...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期StemCellFactorAttenuatesVascularSmoothMuscleApoptosisandIncreasesIntimalHyperplasiaAfterVascularInjury
...er,whetherSCF/c-kitinteractionsexacerbateintimalhyperplasiathroughattenuatingVSMCapoptosisinducedbyvascularinjuryhasnotbeenthoroughlyinvestigated.MethodsandResults-VSMCswerestimulatedwithserumdeprivationandH2O2toinduceapoptosis.Thetranscriptionofc-kitmRNAandtheexpressionofthec-kitproteinbyVSMCsweree...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第3期ApolipoproteinEInterruptsInterleukin-1ßSignalinginVascularSmoothMuscleCells
...anismsremainunclear.WehereinvestigatedtheeffectofapoEonintracellularsignalingbyinterleukin-1ß(IL-1ß),aproinflammatorycytokinepresentinatheroscleroticlesions.MethodsandResults-IL-1ß-inducedexpressionandactivationofinduciblenitricoxidesynthaseandcyclooxygenase-2wereinhibitedbyapoEinv...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第7期鹼性成纖維細胞生長因子及內皮細胞生長因子對兔韌帶細胞增殖的影響
...入bFGF和ECGF,以XTT方法測定細胞的增殖行爲。結果bFGF在1ng/ml時即對MCL細胞有顯著的促增殖作用,5ng/ml時開始對ACL細胞有促進作用,其濃度達50ng/ml時,對兩種細胞的促進作用最大。ECGF在3.125ng/ml時即對MCL細胞有顯著的促增殖作用,...
醫源資料庫;在線期刊;濱州醫學院學報;2009年第32卷第4期HPLC法測定人血清中氨甲喋呤血藥濃度
...3.66%,4.03%。平均回收率爲95.7%,血清中最低檢測濃度爲50ng.ml-1。結論:本法具有快速、準確,操作簡便,流動相成本低等優點。DeterminationofMTXinhumanserumbyHPLCwithUVDetectorZHANGQiang XULi-Ting XIEJing-Wen JIAZheng-Ping(GeneralHospitalofLanzhouCom...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文VitaminDinsufficiencyinchildren,adolescents,andyoungadultswithcysticfibrosisdespiteroutineoralsupplementation
AlishaJRovner,VirginiaAStallings,JoanISchall,MaryBLeonardandBabetteSZemel1FromtheDivisionsofGastroenterology,HepatologyandNutrition(AJR,VAS,JIS,andBSZ)andNephrology(MBL),DepartmentofPediatrics,TheChildren‘sHospitalofPhiladelphia,andthetheDepartmentofBiostatisticsandEpidemiology,CenterforClinicalEp...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年86卷第6期BvitaminstatusandconcentrationsofhomocysteineandmethylmalonicacidinelderlyGermanwomen
...r,Hanover,Germany.2SupportedbygrantsfromtheStollVitaFoundation,Waldshut-Tiengen,Germany.3AddressreprintrequeststoMWolters,InstituteofFoodScience,DepartmentofAppliedChemistry,UniversityofHanover,WunstorferStrasse14,HanoverD-30453,Germany.E-mail:maike.wolters{at}lw.uni-hannover.de.ABSTRACTBackground:P...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年78卷第4期MatrixMetalloproteinase2ActivationofTransformingGrowthFactor-ß1(TGF-ß1)andTGF-ß1-TypeIIReceptorSignalingWithintheAgedArteri
...要】Objective-Tostudymatrixmetalloproteinase2(MMP-2)effectsontransforminggrowthfactor-ß1(TGF-ß1)activationstatusanddownstreamsignalingduringarterialaging.MethodsandResults-WesternblottingandimmunostainingshowedthatlatentandactivatedTGF-ß1aremarkedlyincreasedwithintheaortaofagedFi...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第7期ConnectiveTissueGrowthFactorInducesExtracellularMatrixinAsthmaticAirwaySmoothMuscle
...fEndocrinology,RoyalPrinceAlfredHospital,Sydney,AustraliaABSTRACTTransforminggrowthfactor(TGF)-andconnectivetissuegrowthfactormaybeimplicatedinextracellularmatrixproteindepositioninasthma.WehaverecentlyreportedthatTGF-increasedconnectivetissuegrowthfactorexpressioninairwaysmoothmusclecellsisolatedfr...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2006年第173卷第1期