Antiviraldefense:interferonsandbeyond
ABSTRACTMicelackingtheadaptorproteinthatinitiatesanantiviralresponsedownstreamoftheRNAhelicasesretinoicacid–induciblegeneI(RIG-I)andmelanomadifferentiation-associatedgene5(MDA5)haverecentlybeendescribed.Thesestudieshighlighttheessentialandnonredundantroleofnucleicacidrecognitionintheinductionoftyp...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第8期GeneticPathwaystoPrimaryandSecondaryGlioblastoma
【摘要】90%)areprimaryglioblastomasthatdeveloprapidlydenovo,withoutclinicalorhistologicalevidenceofalessmalignantprecursorlesion.Theyaffectmainlytheelderlyandaregeneticallycharacterizedbylossofheterozygosity10q(70%ofcases),EGFRamplification(36%),p16INK4adeletion(31%),andPTENmutations(25%).Second...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第5期ActivationofMammalianTargetofRapamycinSignalingPromotesCellCycleProgressionandProtectsCellsfromApoptosisinMantleCellLymphoma
【摘要】Mantlecelllymphoma(MCL)ischaracterizedbythet(11;14)andcyclinD1overexpression.However,additionalmoleculareventsaremostlikelyrequiredforoncogenesis,possiblythroughcellcycleandapoptosisderegulation.Wehypothesizedthatmammaliantargetofrapamycin(mTOR)isactivatedinMCLandcontributestotumorprolif...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第12期神經網絡法在使用裂解氣相色譜鑑別中草藥中的應用
...器廠),裂解溫度400℃,裂解環境溫度220℃,裂解時間20 s,裂解升溫速率20℃/ms。HP-5890Ⅱ氣相色譜儀,FID檢測器,使用30 m×0.22 mm(I.D.)塗漬SE-30的石英毛細管柱,氮氣流速爲30mL/min。進樣口溫度250℃,檢測器溫度300℃,色譜...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文淺析抗結核藥物引起副反應及處理
...75例。1.2方法採用全面監督和全程管理的方法,分別以2HRS/4HR、2HRZS/4HRZ、12HZE、2HRES/4HRE、6HR方案常規量化療。治療前查肝功以後每月查肝功,用藥後所出現的各種反應除肝功外均採用反覆單一停藥觀察,來判定導致副反應的藥源...
合作平臺;在線期刊;中華中西醫雜誌;2004年第5卷第6期;藥物Aninflammatorycheckpointregulatesrecruitmentofgraft-versus-hostreactiveTcellstoperipheraltissues
1TransplantationBiologyResearchCenter,BoneMarrowTransplantationSection,2WellmanCenterforPhotomedicine,3CenterforImmunologyandInflammatoryDiseases,MassachusettsGeneralHospital,4DepartmentofPathology,HarvardMedicalSchool,Boston,MA02129TransferofTcellstofreshlyirradiatedallogeneicrecipientsleadstotheir...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第8期CystamineandcysteamineincreasebrainlevelsofBDNFinHuntingtondiseaseviaHSJ1bandtransglutaminase
1InstitutCurie,CNRSUMR146,Orsay,France.2DepartamentdeBiologiaCellulariAnatomiaPatològica,FacultatdeMedicina,Institutd’InvestigacionsBiomèdiques,UniversitatdeBarcelona,Barcelona,Spain.3INSERM,AvenirGroup,LaboratoryofGenomicBiology,CentrePaulBroca,Paris,France.4URACEA/CNRS2210,ServiceHospitalierFr...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第5期Regulationofthegerminalcentergeneprogrambyinterferon(IFN)regulatoryfactor8/IFNconsensussequence-bindingprotein
1LaboratoryofImmunopathology,NationalInstituteofAllergyandInfectiousDiseases,2BCellBiologyGroupandAutoimmunityBranch,NationalInstituteofArthritisandMusculoskeletalandSkinDiseases,3LaboratoryofMolecularGrowthRegulation,NationalInstituteofChildHealthandHumanDevelopment,NationalInstitutesofHealth,Bethe...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期RegulationofosteoclastfunctionandbonemassbyRAGE
1InstituteofMolecularMedicineandGenomicsandDepartmentofNeurology,MedicalCollegeofGeorgia,Augusta,GA,309122SavannahRiverNationalLaboratory,Aiken,SC298083DepartmentofMedicineI,UniversityofHeidelberg,69120Heidelberg,Germany4DepartmentofPathology,UniversityofAlabamaatBirmingham,Birmingham,AL352945Dean...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期C1q-DeficiencyIsNeuroprotectiveAgainstHypoxic-IschemicBrainInjuryinNeonatalMice
theDepartmentsofPediatrics(V.S.T.,R.I.S.,C.C.),Medicine(S.P.M.),andNeurosurgery(S.A.S.,M.E.S.,E.S.C.),ColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork,NYRheumatologySection(M.B.),FacultyofMedicine,ImperialCollege,London,UKDepartmentofMedicine(D.J.P.),UniversityofMichigan,AnnArbor,MI.Abstract...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第10期