ComparativeEffectsofPaclitaxelandRapamycinonSmoothMuscleMigrationandSurvival
...asepathwayssimilarly.However,rapamycinpotentlyactivatesAKT-dependentsignaling,aneffectthatoverridesthedownregulationofthispathwaybyinsulinresistanceandthatcausesphosphorylationoftheAKT-dependenttranscriptionfactorFOXO1.Thiseffectisassociatedwithattenuationoftheanti-migratoryeffectsofrapamycinunderhi...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第7期ConstitutionalthinnessandleananorexianervosadisplayoppositeconcentrationsofpeptideYY,glucagon-likepeptide1,ghrelin,andleptin
NatachaGermain,BogdanGalusca,CarelWLeRoux,CecileBossu,MohammadAGhatei,FrancoisLang,StephenRBloomandBrunoEstour1FromtheDepartmentsofEndocrinology(NG,BG,CB,andBE)andPsychiatry(FL),CHUSaintEtienne,StEtienne,France,andEndocrineUnit,ImperialCollegeFacultyofMedicine,HammersmithHospital,London,UnitedKingdo...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第4期HumanEndothelialProgenitorCellsTolerateOxidativeStressDuetoIntrinsicallyHighExpressionofManganeseSuperoxideDismutase
...bjective—Endothelialprogenitorcells(EPCs)displayauniqueaptitudetopromoteangiogenesisandrestoreendothelialfunctionofinjuredvessels.Howprogenitorcellscanexecutearegenerativeprogramintheunfavorableenvironmentofinjury/inflammation-inducedoxidativestressispoorlyunderstood.WehypothesizedthatEPCsareresis...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第11期Stereochemicalassignment,antiinflammatoryproperties,andreceptorfortheomega-3lipidmediatorresolvinE1
...tryandLokerHydrocarbonResearchInstitute,UniversityofSouthernCalifornia,LosAngeles,CA90089Theessentialfattyacideicosapentaenoicacid(EPA)presentinfishoilsdisplaysbeneficialeffectsinarangeofhumandisordersassociatedwithinflammationincludingcardiovasculardisease.ResolvinE1(RvE1),anewbioactiveoxygenatedpr...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第5期CriticalRoleofAngiotensinIIinExcessSalt-InducedBrainOxidativeStressofStroke-ProneSpontaneouslyHypertensiveRats
...edicalScience,Osaka,Japan.AbstractBackgroundandPurpose—ThedetailedroleofangiotensinIIinsalt-exacerbatedstrokeisunclear.WeexaminedtheroleofangiotensinIIinsalt-acceleratedstrokeofstroke-pronespontaneouslyhypertensiverats(SHRSP).Methods—Salt-loadedSHRSPwereorallygiventheangiotensinIItype1(AT1)recep...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第5期HPLC法測定鹽酸氟西汀的有關物質及其膠囊的含量
...西汀中7個有關物質峯,其鹽酸氟西汀的最小檢出量爲0.1ng;同時,以咖啡因爲內標,測定了其膠囊的含量,線性範圍爲20.02~200.2mg/L(r=0.9994,n=5),平均回收率爲99.3%(RSD=0.92%,n=5),多次測定的精密度(RSD)爲0.10%~0.30%(n=3~5)...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文ANovelVitaminDDerivativeActivatesBoneMorphogeneticProteinSignalinginMCF10BreastEpithelialCells
...y-16,23(Z)-diene-26,27-hexafluoro-19-nor-cholecalciferol(Ro2198)]inmodulatingthetransforminggrowthfactor-(TGF-)/bonemorphogeneticprotein(BMP)systeminMCF10immortalizedbreastepithelialcells.Wefoundthat1,25(OH)2D3,Ro3582,andRo2198allenhancedBMP/Smadsignalingbyincreasingthephosphorylationofreceptor-regu...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期學齡兒童遺精初潮前期血清瘦素的變化
...義血清瘦素在青春期的變化已反覆被國內外研究所證實。然而,血清瘦素在青春期的變化具有什麼意義呢?本組研究採用逆向分析,對已遺精/來潮的男/女生進行回顧跟蹤,前一年資料顯示:已遺精/來潮組中一年前未遺精/初潮者的...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第8B期ProgesteroneAntagonizestheVasoprotectiveEffectofEstrogenonAntioxidantEnzymeExpressionandFunction
...thepathogenesisofatherosclerosisandcanbeeffectivelyinfluencedbyradicalscavengingenzymes.Estrogensexertantioxidativeeffectsinthevasculature;however,cotreatmentwithprogesteronemayabrogatethevasoprotectiveeffectsofestrogen.Therefore,theeffectsofprogesteroneontheproductionofreactiveoxygenspecies(ROS)and...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第11期AcuteregulationofOAT3-mediatedestronesulfatetransportinisolatedrabbitrenalproximaltubules
...niontransport.Incontrast,epidermalgrowthfactor(EGF)increasedESuptakefollowingactivationofMAPK.ExposuretoPGE2ordibutyryl(db)-cAMPalsoenhancedESuptake.StimulationproducedbyPGE2anddb-cAMPwaspreventedbythePKAinhibitorH-89,indicatingthatthisstimulationrequiredPKAactivation.Inaddition,inhibitionofcyclooxy...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第11期