手足口病併發症的研究進展

...FMD）是腸道病毒引起的常見傳染病之一。柯薩奇病毒A16（CA16）和腸道病毒71型（EV71）是本病的主要致病原。3歲以下嬰幼兒發病率最高，尤其是2歲以內最多見。每年6～8月爲流行季節，傳播途徑主要是呼吸道，也可進食被污染的...

Bmi-IsEssentialfortheTumorigenicityofNeuroblastomaCells

【摘要】Activationofoncogenesunderliesthepathogenesisofmosthumancancers.Inneuroblastoma,amplificationoftheoncogeneMYCNoccursin22%ofcasesandisassociatedwithadvancedstagesofthediseaseandpoorprognosis.Identificationofotheroncogenesthatareconsistentlymutatedoroverexpressedinneuroblastomaiscrucialfor...

TheTwoIsoformsoftheNa+/Ca2+Exchanger,NCX1andNCX3,ConstituteNovelAdditionalTargetsfortheProsurvivalActionofAkt/ProteinKinaseBPathway

【關鍵詞】Na+/Ca2+ExchangerTheproteinsNCX1,NCX2,andNCX3expressedontheplasmamembraneofneuronsplayacrucialroleinionicregulationbecausetheyarethemajorbidirectionalsystempromotingtheeffluxandinfluxofNa+andCa2+ions.Here,wedemonstratethatNCX1andNCX3proteinsarenoveladditionaltargetsforthesurvivalactio...

中醫藥抗腦缺血再灌注損傷的作用機制研究

...障礙、局部酸中毒、炎性介質釋放、自由基損傷、細胞內Ca2+超載、興奮性氨基酸的毒性作用以及各種細胞因子在腦缺血後的病理生理機制中發揮着重要的作用。目前用於腦缺血治療的化學藥物包括：抗栓藥（溶栓藥、抗凝藥、...

亞健康的微醫學研究

...胞的變形性能、調節紅細胞內離子平衡，致使紅細胞穩定Ca2+的內環境發生改變。紅細胞內Ca2+過多對細胞有損害作用，正常情況下，紅細胞內Ca2+含量極微（48μM），細胞外的濃度（10～15mM）要高得多。由於紅細胞膜受損，Ca2+的透...

何首烏對實驗性衰老大鼠海馬內突觸及突觸素表達的影響

...色法、透射電鏡技術結合圖像分析系統比較各組大鼠海馬CA1、CA3區突觸素表達和突觸體視學變化。結果與模型組相比，何首烏2、4g/kg能顯著降低大鼠水迷宮實驗的平均潛伏期，升高跨越平臺次數及在Ⅳ象限內的游泳時間佔整個遊...

ModulationoftheCa2PermeableCationChannelTRPV4byCytochromeP450EpoxygenasesinVascularEndothelium

TheDepartmentofPhysiology(J.V.,G.O.,A.J.,T.V.,B.N.),CampusGasthuisberg,KULeuven,BelgiumInstitutfeKardiovaskulrePhysiologie(B.F.,I.F.,R.B.),JohannWolfgangGoethe-UniversittTheodor-SternKai7,FrankfurtamMain,GermanyDepartmentofEntomologyandUCDavisCancerCenter(C.M.,B.D.H.),UniversityofCalifornia,DavisJic...

Calciumabsorptionisnotincreasedbycaseinophosphopeptides

...er-tait{at}bbsrc.ac.uk.ABSTRACTBackground:Oneofthesuggestedhealthbenefitsofcaseinophosphopeptides(CPPs)istheirabilitytoenhancecalciumabsorption.ThispossibilityisbasedontheassumptionthattheyresistproteolysisintheuppergastrointestinaltractandmaintaincalciuminasolubleformatalkalinepHinthedistalileum.Ob...

線粒體膜電壓依賴陰離子通道

...閉合時孔道直徑0.4～0.5nm，此時VDAC反而可以允許K+、Na+和Ca2+等小分子陽離子通過。這種選擇性的改變大大減少了陰離子電流。這不僅表現在通道兩邊的靜電荷抑制陰離子的通過，而且通道的孔徑也減小，阻礙陰離子通過通道，特...

Epidemiologyandmolecularanalysisofherpessimplexkeratitisrequiringprimarypenetratingkeratoplasty

...n,CT,USA3FrancisIProctorFoundationandDepartmentofOphthalmology,UniversityofCaliforniaSanFrancisco,SanFrancisco,CA,USAABSTRACTAims:Todeterminewhetherherpessimplexkeratitis(HSK)hasdeclinedasanindicationforpenetratingkeratoplasty(PKP)attheUniversityofCaliforniaSanFrancisco(UCSF)overthepast30years.Metho...