TetrahydrobiopterinandCardiovascularDisease
...kin-1ß.CytokineactivationmayinvolvecoordinatedactivationofNF-BandtheJak2/Statpathway,8andcanincreaseBH4levelsbyincreasingGTPCH-1expression,9-12reducingGFRPexpression,5andincreasingPTPSexpression.12BH4synthesisisalsostimulatedbyinsulinviaaphosphatidylinositol-3-kinase-dependentactivationofGTPCH...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第11期Effectsofwaterrestrictionongeneexpressioninmouserenalmedulla:identificationof3HSD4asacollectingductprotein
...nsistedofstepwiseincreaseintemperaturefrom72to99°C.Asinglepredominantpeakwasobservedinthedissociationcurveofeachgene,supportingthespecificityofthePCRproduct.Ctnumbers(thresholdvalues)weresetwithintheexponentialphaseofthePCRandwereusedtocalculatetheexpressionlevelsofthegenesofinterestandwerenorma...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第7期DevelopmentandEvaluationofaMultitargetReal-TimeTaqmanReverseTranscription-PCRAssayforDetectionoftheSevereAcuteRespiratorySyndrome-Associated
...nthewestpartofHubeiProvince,People‘sRepublicofChina.INTRODUCTIONTheoutbreakofsevereacuterespiratorysyndrome(SARS)in2003severelyharmedpublichealthandtheglobaleconomy(11).TheetiologicagentofSARSwasidentifiedasanovelcoronavirus,theSARS-associatedcoronavirus(SARS-CoV)(3,11,18),anenveloped,positive-str...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第5期ThesurvivalkinasesAktandPimaspotentialpharmacologicaltargets
...Medicine,UniversityofPennsylvania,Philadelphia,Pennsylvania,USA.AbstractTheAktandPimkinasesarecytoplasmicserine/threoninekinasesthatcontrolprogrammedcelldeathbyphosphorylatingsubstratesthatregulatebothapoptosisandcellularmetabolism.ThePI3K-dependentactivationoftheAktkinasesandtheJAK/STAT–dependent...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第10期Originofatherosclerosisinchildhoodandadolescence
...sianaStateUniversityMedicalCenter,NewOrleans.2PresentedatthesymposiumFatIntakeDuringChildhood,heldinHouston,June89,1998.3SupportedbygrantsfromtheNationalHeart,Lung,andBloodInstituteandothersourcestotheinstitutionscooperatinginthemulticenterstudy,ThePathobiologicalDeterminantsofAtherosclerosisi...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年72卷第5期StatinsDecreaseToll-LikeReceptor4ExpressionandDownstreamSignalinginHumanCD14+Monocytes
...ithuntreatedmonocytes;P0.005),transcriptlevels(68±6.3%;P0.002),decreasedIRAKphosphorylation(37±8.3%;P0.05),andLPS-inducedIL-6,IL-12,tumornecrosisfactor(TNF)-,andB7-1expression(P0.05).FourweeksoftreatmentwithatorvastatinsignificantlyreducedTLR4expressiononcirculatingCD14+monocytesby36.2±4.2%(P0.05...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第7期ANovelAsparticProteinase-LikeGeneExpressedinStratifiedEpitheliaandSquamousCellCarcinomaoftheSkin
...fpatientswithpsoriasis,lichenruber,eczema,andactinickeratoseswereroutinelytakenfordiagnosticpurposeattheDepartmentofDermatology(UniversityofCologne).Theskinlesionshadnotpreviouslyreceivedanylocaltreatmentforatleast1week.SkinbiopsiesfrompatientswithkeratoacanthomaorSCCwereobtainedfromsurgicalexcision...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第4期PlasminTriggersCytokineInductioninHumanMonocyte-DerivedMacrophages
...etramercomposedofannexinA2andS100A10withsubsequentstimulationofJanuskinaseJAK1/TYK2signaling.JAK1/TYK2leadstoSTAT3activation,Akt-dependentNF-Bactivation,andphosphorylationofextracellularsignal-regulatedkinase1/2andmitogen-activatedkinasep38.ThesesignalingpathwaystriggernucleartranslocationofSTAT3and...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第6期Effectsofcalcium,dairyproduct,andvitaminDsupplementationonbonemassaccrualandbodycompositionin10-12-y-oldgirls:a2-yrandomizedtrial
...ngJuWang,MiiaSuuriniemi,HarriSuominen,AnittaMahonen,PatrickHFNicholson,KaisaKIvaska,RiittaKorpela,ClaesOhlsson,KalervoHVäänänenandFrancesTylavsky1FromtheDepartmentsofHealthSciencesandCellBiology,UniversityofJyväskylä,Jyväskylä,Finland(SC,AL,MA,QJW,MS,HS,andPHFN);th...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年82卷第5期Srcfamilykinaseinvolvementinratpreglomerularmicrovascularcontractileand[Ca2+]iresponsestoANGII
...dfromexplantsandstudiedafter35daysinculture.InuntreatedPVSMCs,ANGIIevokedpeak(=293±66nM)andplateau(=23±8nM)increasesin[Ca2+]i.InPVSMCspretreatedwithPP2,baseline[Ca2+]iwasunaltered,butboththepeak(=140±22nM)andplateau(=3±2nM)phasesoftheANGIIresponseweresignificantlyreducedcomparedwithuntreatedcell...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第4期