PKCIsNecessaryforSmad3ExpressionandTransformingGrowthFactorß-InducedFibronectinSynthesisinVascularSmoothMuscleCells
...ective-Thepurposeofthesestudiesistoinvestigatethemechanismbywhichtransforminggrowthfactor(TGF)ß1regulatesthesynthesisoftheextracellularmatrixproteinfibronectin(FN).MethodsandResults-TGFß1elicitedatime-dependentinductionofFNproteinandmRNAinA10rataorticsmoothmusclecells(SMCs).Ectopicexpres...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第4期cAMPInhibitsTransformingGrowthFactor--StimulatedCollagenSynthesisviaInhibitionofExtracellularSignal-RegulatedKinase1/2andSmadSignalinginCard
...diacfibroblastsproduceanddegradeextracellularmatrixandarecriticalinregulatingcardiacremodelingandhypertrophy.Cytokinessuchastransforminggrowthfactor-(TGF-)playafundamentalroleinthedevelopmentoftissuefibrosisbystimulatingmatrixdepositionandotherprofibroticresponses,butlessisknownaboutpathwaysthatmigh...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期InterferonβAugmentsTuberousSclerosisComplex2(TSC2)-DependentInhibitionofTSC2-NullELT3andHumanLymphangioleiomyomatosis-DerivedCellProliferation
【關鍵詞】InterferonβLymphangioleiomyomatosis(LAM),ararepulmonarydisorder,manifestsasanabnormalneoplasticgrowthofsmoothmuscle-likecellswithinthelungs.Mutationalinactivationoftumorsuppressortuberoussclerosiscomplex2(TSC2)inLAMconstitutivelyactivatesthemammaliantargetofrapamycin(mTOR)/p70S6kinas...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期HypovitaminosisDisassociatedwithinsulinresistanceandßcelldysfunction
KenCChiu,AudreyChu,VayLiangWGoandMohammedFSaad1FromtheDivisionofClinicalEpidemiologyandPreventiveMedicine(KCC,AC,MFS)andtheCenterforClinicalNutrition(VLWG),DepartmentofMedicine,UniversityofCalifornia,LosAngeles,SchoolofMedicine,LosAngeles.2SupportedbygrantsMO1RR00865fromtheUSPublicHealthService(toth...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年79卷第5期TransitionfromIntravenousEpoprostenoltoIntravenousTreprostinilinPulmonaryHypertension
...isDukeUniversityMedicalCenter,Durham,NorthCarolinaUniversityofAlabama,Birmingham,AlabamaUniversityofMichigan,AnnArbor,MichiganColumbiaUniversityCollegeofPhysiciansandSurgeons,NewYork,NewYorkABSTRACTRationale:Intravenousepoprostenolimprovesexercisecapacityandsurvivalinpatientswithpulmonaryarterialhyp...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第12期Requirementoftheepidermalgrowthfactorreceptorinrenalepithelialcellproliferationandmigration
...Weshowedthatrenalproximaltubularcells(RPTC)canproliferateandmigratefollowingplatingandoxidantormechanicalinjuryintheabsenceofexogenousgrowthfactors;however,themechanismsofthisresponseremainunclear.Weexaminedwhetherepidermalgrowthfactorreceptor(EGFR)signalingisactivatedfollowingplatingandmechanicalin...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第9期Lipoprotein-AssociatedPhospholipaseA2andPrognosisAfterMyocardialInfarctionintheCommunity
...protein-associatedphospholipaseA2(Lp-PLA2),aninflammatorybiomarker,indefiningriskaftermyocardialinfarction(MI).MethodsandResults-OlmstedCounty,Minn,residentswhoexperiencedanMImeetingstandardizedcriteriabetween2003and2005(n=271)wereprospectivelyidentifiedandfollowed.Lp-PLA2levelsweremeasuredatbaselin...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第11期AnalysisofGas6inHumanPlateletsandPlasma
...andMolecularPathology,MedicalandHealthScienceCenter,UniversityofDebrecen,Hungary.CorrespondencetoBj?rnDahlb?ckMD,PhD,ProfessorofBloodCoagulationResearch,UniversityofLund,DepartmentofLaboratoryMedicine,DivisionofClinicalChemistry,Wallenberglaboratory,UniversityHospital,Malm?,S-20502Malm?,Sweden.E-mai...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第6期高雄激素症狀的先天性腎上腺皮質增生症(附4例報告)
...部有少許白紋,雙側睾丸6ml,陰毛濃。F0.19μmol/L,ACTH115.0ng/L,T7.3nmol/L,P127.2nmol/L,臥位ALD275.3pg/ml,PRA3.82ng/(ml·h),立位ALD353.8pg/ml,PRA5.14ng/(ml·h);K4.07mmol/L,Na142.4mmol/L;MR示垂體形態、大小屬正常範圍,雙側腎上腺結節性...
醫源資料庫;在線期刊;中華現代內科學雜誌;2006年第3卷第7期BiologicalAssessmentofAspirinEfficacyonHealthyIndividuals
...romboxaneB2(11-dTxB2)inallcases.However,variabilityonthepre-aspirinlevel(range72.4to625.9ng/mmolcreatinine)ledtosubstantialdifferencesintheresidualamountofthemetabolitebetweensubjectstreatedwithaspirin(range12.9to118.0ng/mmolcreatinine).Finally,therewasnoinfluenceofplateletglycoproteinIIb/IIIa(Pro33...
醫源資料庫;在線期刊;中風學雜誌;2005年第36卷第2期