ActivationoftheFlt3signaltransductioncascaderescuesandenhancestypeIinterferon–producinganddendriticcelldevelopment
...tzerlandFlt3ligand(Flt3L)isanonredundantcytokineintypeIinterferon–producingcell(IPC)anddendriticcell(DC)development,andIPCandDCdifferentiationpotentialisconfinedtoFlt3+hematopoieticprogenitorcells.Here,weshowthatoverexpressionofhumanFlt3inFlt3–(Flt3–Lin–IL-7R–Thy1.1–c-Kit+)andFlt3+(Flt3+...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期HumanPlacentalHypoxia-InducibleFactor-ExpressionCorrelateswithClinicalOutcomesinChronicHypoxiainVivo
...xia-induciblefactor(HIF)mayfacilitateplacentaloxygentransportatHAbyincreasingerythropoiesisandplacentalangiogenesis.WethereforeinvestigatedHIFexpressionanditsregulatorymechanismsinplacentasfromnormalpregnanciesathigh(3100m),moderate(1600m),andsealevel(75m)altitudes.Moderate-altitudeandsealevelplacen...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第6期LowfolatestatusisassociatedwithimpairedcognitivefunctionanddementiaintheSacramentoAreaLatinoStudyonAging
MarisaIRamos1,LindsayHAllen1,DanMMungas1,WilliamJJagust1,MaryNHaan1,RalphGreen1andJoshuaWMiller11FromtheSchoolofMedicine,DepartmentsofMedicalPathologyandLaboratoryMedicine(MIR,RG,andJWM),Neurology(DMM),andNutrition(LHA),UniversityofCalifornia,Davis,CA;theUSDepartmentofAgriculture,ARSWesternHumanNutr...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年82卷第6期CriticalRoleoftheCarboxylTerminusofProline-richTyrosineKinase(Pyk2)intheActivationofHumanNeutrophilsbyTumorNecrosisFactor
...owedananalysisofindividualPyk2domainsnotpossiblewithchemicalinhibitors.Actingasadominantnegative,theCOOHterminusofPyk2fusedtoaTatpeptide(Tat-CT),butnototherregionsofPyk2,specificallyinhibitedtherespiratoryburstofcellsrespondingtotumornecrosisfactor(TNF),Salmonella,orListeria,whilesparingresponsesind...
醫源資料庫;在線期刊;美國病理學雜誌;2003年第162卷第1期松果體、中樞核團與淋巴細胞間信息傳遞的晝夜節律△
...神經遞質是神經內分泌和免疫系統之間的重要橋樑物質。然而,從細胞信使晝夜節律傳導的角度探討中樞核團與免疫細胞間聯繫的研究,文獻中尚未查見。本實驗結果顯示的MT與cAMP/cGMP間的位相性關係,提示二者在介導中樞與外...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學CriticalRoleoftheCarboxylTerminusofProline-richTyrosineKinase(Pyk2)intheActivationofHumanNeutrophilsbyTumorNecrosisFactorSeparationofSig
...owedananalysisofindividualPyk2domainsnotpossiblewithchemicalinhibitors.Actingasadominantnegative,theCOOHterminusofPyk2fusedtoaTatpeptide(Tat-CT),butnototherregionsofPyk2,specificallyinhibitedtherespiratoryburstofcellsrespondingtotumornecrosisfactor(TNF),Salmonella,orListeria,whilesparingresponsesind...
醫源資料庫;在線期刊;實驗醫學雜誌;2003年第197卷第1期99mTc示蹤法初步研究注射NGF家兔藥代動力學
【摘要】目的使用99mTc示蹤初步研究注射用NGF在家兔體內藥代動力學。方法將NGF用99mTc標記,利用同位素示蹤法和TCA沉澱法測得NGF含量與放射性計數的線性關係,並由靜脈注射至家兔體內,通過上述檢測方法得到不同時段血漿中...
醫源資料庫;在線期刊;中華醫學實踐雜誌;2005年第4卷第11期MacrophageColony-StimulatingFactorImprovesCardiacFunctionafterIschemicInjurybyInducingVascularEndothelialGrowthFactorProductionandSurvivalof
【摘要】Macrophagecolony-stimulatingfactor(M-CSF),knownasahematopoieticgrowthfactor,inducesvascularendothelialgrowthfactor(VEGF)productionfromskeletalmuscles.However,theeffectsofM-CSFoncardiomyocyteshavenotbeenreported.Here,weshowM-CSFincreasesVEGFproductionfromcardiomyocytes,protectscardiomyocy...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第10期SelectiveupregulationoftheADP-ribosylcyclasesCD38andCD157byTNFbutnotbyRANK-Lrevealsdifferencesindownstreamsignaling
...ofthesameadaptormolecules.However,despitethesesimilarities,nodefinedsignalingschematichasemergedtoshowhoweachcytokinefavorsparticularpathways.Inthisreport,weinvestigatewhetherTNFandRANK-LdifferentiallyregulateADP-ribosylcyclases-enzymesthatareuniqueinbeingcrucialforimmunologicalfunctionyetdetrimenta...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第9期SMP-534inhibitsTGF--inducedECMproductioninfibroblastcellsandreducesmesangialmatrixaccumulationinexperimentalglomerulonephritis
...ories,SumitomoPharmaceuticalsResearchDivision,Osaka,JapanABSTRACTTransforminggrowthfactor-(TGF-)isapotentfibroticfactorresponsibleforthesynthesisofextracellularmatrix(ECM)andisimplicatedasthemajordeterminantinpathogenesisofchronicfibroses,includingkidney.ThenovelsmallcompoundSMP-534reducedECMproduct...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第11期