IdentificationofHypertension-RelatedGenesThroughanIntegratedGenomic-TranscriptomicApproach
...egenessalt-susceptibilityIntroductionThegeneticbasisofhypertension,acomplexdisease,remainselusive.Geneticmappingofquantitativetraitloci(QTLs),agenomicstrategy,hassuccessfullyyieldedalargenumberofhypertension-relatedQTLs.Asastand-alonetechnology,however,ithasgenerallyfailedtoidentifythedefinitiveseto...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期急性下壁心肌梗死胸前導聯ST段下移對近期預後影響的分析
...eadsinacuteinferiormyocarˉdialinfarction:Concomitantleftanteriordescendingdisease?AmJCarˉdiol,1981,48:1003.3GoldbergHL,BorerJS,JacobsteinJG,etal.AmteriorSTsegmentdeˉpressioninacuteinferiormyocardialinfraction:indicatorofposterolateralinfarction.AmJcardiol,1981,48:1009.4BodenWE,Bou...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第4A期Miscuesonthe“lackofMEF2Amutations“incoronaryarterydisease
...ommentonthereportbyWengetal.thatclaimedlackofMEF2Amutationsincoronaryarterydisease(CAD)(1)andtheaccompanyingcommentarybyAltshulerandHirschhorn(2).Theyanalyzedtheexonsandexon-intronboundariesoftheMEF2Agenein300CADpatientsand300elderlysubjectsbydirectsequenceanalysis.First,thenewreportactuallyfound1pa...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第6期LateDiagnosisDefinesaUniquePopulationofLong-termSurvivorsofCysticFibrosis
...mycobacteriasweatchlorideCysticfibrosis(CF)isthemostcommon,lethal,inheriteddiseaseinwhites,affecting1in2,500individuals(1).WhenCFwasoriginallydescribedbyD.Andersenin1936,theaffectedpopulationwasidentifiedaschildrenwithseverepancreaticinsufficiency,recurrentpulmonaryinfections,andalifeexpectancyofles...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第3期GeneticRiskforIschemicandHemorrhagicStroke
...isfactor(TNF)gene(TNF),andtheGA(Gly243Asp)polymorphismofthepolycystickidneydisease1-likegene(PKD1-like)weresignificantlyassociatedwithsubarachnoidhemorrhage.Conclusions-IL6genotypemaybeusefulinassessingthegeneticriskforatherothromboticcerebralinfarctionandintracerebralhemorrhage,andgenotypesforUCP3,...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第8期CardiovasculardiseaseriskfactorsanddietofFulanipastoralistsofnorthernNigeria
...ttleisknownabouttheirserumlipidprofilesandcorrespondingriskofcardiovasculardisease.Objective:Wemeasuredserumlipid,homocysteine,folate,andvitaminB-12concentrationsinFulanimenandwomenandassessedthenutrientcontentoftheirdiet.Design:Bloodsamplesfrom42men(1864yold)and79women(1577yold)livingin...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2001年74卷第6期Disease-associatedmutationsaffectintracellulartrafficandparacellularMg2+transportfunctionofClaudin-16
...ntswithfamilialhypomagnesemiawithhypercalciuriaandnephrocalcinosis(FHHNC),adiseaseofexcessiverenalMg2+andCa2+excretion.Hereweshowthatdisease-causingmutationscanleadtotheintracellularretentionofCldn16oraffectitscapacitytofacilitateparacellularMg2+transport.Nineofthe21Cldn16mutantswecharacterizedwerer...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第4期DeterminantsofplasmatotalhomocysteineconcentrationintheFraminghamOffspringcohort
...homocysteineconcentrationisassociatedwithanincreasedriskofocclusivevasculardisease(1,2).Establisheddeterminantsoffastingtotalhomocysteine(tHcy)concentrationincludefolateandvitaminB-12status,serumcreatinineconcentration,andrenalfunction.ElevatedfastingtHcyconcentrationsareassociatedwithlowercirculati...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2001年73卷第3期Dietaryadviceinfamilymedicine
...ptualbasisofdietaryadviceinfamilymedicine.Giventhelargenumberofillnessesanddiseasesencounteredinfamilypracticeforwhichdietandnutritionarerelevantinterventions,food-relatedadviceisanimportantpartofdailypractice.Toenhancetheeffectivenessofdiet-relatedadviceandcounselinginfamilypractice,itshouldbelinke...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年77卷第4期一項關於心絞痛患者的研究最新結果顯示,Procoralan(R)(伊伐佈雷定)*可降低心臟病事件發病率
...1).FoxK、FordI、StegPG等。Ivabradineforpatientswithstablecoronaryarterydiseaseandleftventriculardysfunction(Beautiful):arandomized,double-blind,placebo-controlledtrial.Lancet2008,372,807-816.(2).TardifJ-C、FordI、TenderaM等。Efficacyofivabradine,anewselectiveIfinhibitor,comparedwithatenololi...
行業資訊;臨牀快報;心腦血管相關