RandomizedControlledTrialofanAdjuvantedHumanPapillomavirus(HPV)Type6L2E7Vaccine:InfectionofExternalAnogenitalWartswithMultipleHPVTypesan
...onceptoftherapeuticvaccination.AtherapeuticvaccinecomposedofHPV-6L2E7fusionproteinandAS02Aadjuvantwasevaluatedinconjunctionwithconventionaltherapiesinsubjectswithanogenitalwarts.Methods.Atotalof457subjectswithanogenitalwartswerescreened,ofwhich320withHPV-6and/orHPV-11infectionwereenrolledinto2double...
醫源資料庫;在線期刊;傳染病學雜誌;2005年第191卷第24期TargetingtoC-TerminalMyosinHeavyChainMayExplainMechanotransductionInvolvingFocalAdhesionKinaseinCardiacMyocytes
...cstructureisorganizedbyN-terminaltitinZrepeatslinkedto-actininandassociatedproteinssuchasMLP,ALP,telethonin(T-cap),cypher/Zasp,andmyotilin.4,5Notably,MLPnullmicewereshowntofailtoupregulatebrainandatrialnatriureticfactorsmRNAinresponsetostretch.6Humantitinmutationsaswellasdeletionofthe-actininbinding...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第1期Responseofdescendingvasarectatoluminalpressure
...ts,respectively.AllinvestigationsinvolvinganimalusewereperformedaccordingtoprotocolsapprovedbytheInstitutionalAnimalCareandUseCommitteeoftheUniversityofMaryland.Videomicroscopyandmeasurementofvesseldiameters.Toquantifychangesinvesseldiameter,microperfusionexperimentsweremonitoredwithavideocamera(Dag...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第9期EssentialRoleofaCa2+-Selective,Store-OperatedCurrent(ISOC)inEndothelialCellPermeability
...icregulationofinterendothelialcellgapformationthatincreaseswater,solute,andproteinpermeability.However,Ca2+entryspecificallythroughstore-operatedchannelsprovidesa[Ca2+]isourcethatissufficienttoincreasepermeabilityacrossasubsetofmacrovascular,butnotacrossmicrovascular,endothelialcells.1eC3Similarly,a...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第4期VariabilityofClostridiumdifficileSurfaceProteinsandSpecificSerumAntibodyResponseinPatientswithClostridiumdifficile-AssociatedDisease
...cosalinfections.Thisstepismediatedbyimportantvirulencefactors,suchassurfaceproteins.Clostridiumdifficilesurfaceproteinshavebeenidentifiedas(i)adhesins(theflagellarcapproteinFliD;theflagellinFliC;andthecellwallproteinCwp66withatwodomain-structure[Cw66N-terminalandCwp66C-terminaldomains])and(ii)protea...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第10期DistributionofthetightjunctionproteinsZO-1,occludin,andclaudin-4,-8,and-12inbladderepithelium
...s.UrinarybladderswereobtainedfromfemaleNewZealandWhiterabbits(3-4kg),femaleSwiss-WebsterorC57BL/6Jmice(3-4moold),orfemaleSprague-Dawleyratsweighing275-350g.Allanimalswerefedastandarddietwithfreeaccesstowaterbeforeeuthanization.Rabbitswereeuthanizedwith300mgofpentobarbitalsodium(dissolvedin5mlofwater...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第8期Impairmentofsmallintestinalproteinassimilationinpatientswithend-stagerenaldisease:extendingthemalnutrition-inflammation-atherosclerosisconcept
...en,Belgium.E-mail:pieter.evenepoel{at}uz.kuleuven.ac.be.ABSTRACTBackground:Proteinmalnutritionisacommonfindinginrenaldisease.Recently,weshowedthatimpairedproteinassimilation(digestionandabsorption)maycontributetoproteinmalnutritioninnondiabeticpatientswithchronicrenalfailure.Objective:Theaimofthepre...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第6期Aconsensussequenceintheendothelin-BreceptorsecondintracellularloopisrequiredforNHE3activationbyendothelin-1
...sexpressingtheendothelin-A(ETA)receptor.However,ET-1causessimilarpatternsofproteintyrosinephosphorylation,adenylylcyclaseinhibition,andincreasesincell[Ca2+]inETA-andETB-expressingOKPcells,implyingthatanadditionalmechanismisrequiredforNHE3stimulationbytheETBreceptor.ThepresentstudiesusedETAandETBrece...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第4期InvolvementofNeuron-DerivedOrphanReceptor-1(NOR-1)inLDL-InducedMitogenicStimulusinVascularSmoothMuscleCells:RoleofCREB
...italdelaSantaCreuiSantPau,Barcelona,SpainABSTRACTObjective—Lowdensitylipoproteins(LDLs)modulatetheexpressionofkeygenesinvolvedinatherogenesis.Recently,wehaveshownthatthetranscriptionfactorneuron-derivedorphanreceptor-1(NOR-1)isinvolvedinvascularsmoothmusclecell(VSMC)proliferation.Ouraimwastoanalyz...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2004年第24卷第4期Ficollanddextranvs.globularproteinsasprobesfortestingglomerularpermselectivity:effectsofmolecularsize,shape,charge,anddeformability
...theglomerularcapillarywall(GCW)aremarkedlyhigherthanthoseforneutralglobularproteinsofanequivalentinvitroStokes-Einstein(SE)radius.Physicaldata,obtainedby“crowding“experimentsormeasurementsofintrinsicviscosity,suggestthattheFicollmoleculeexhibitsaratheropen,deformablestructureandthusdeviatesfroma...
醫源資料庫;在線期刊;美國生理學雜誌;2005年第288卷第4期