EndotoxinandcisplatinsynergisticallystimulateTNF-productionbyrenalepithelialcells
【摘要】Acuterenalfailureoftenoccursintheclinicalsettingofmultiplerenalinsults.Tumornecrosisfactor-(TNF-)hasbeenimplicatedinthepathogenesisofcisplatinnephrotoxicity,ischemia-reperfusioninjury,andendotoxin-inducedacuterenalfailure.Thecurrentstudiesexaminedtheinteractionsbetweencisplatinandendotox...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第2期VitaminKstatusofhealthyJapanesewomen:age-relatedvitaminKrequirementfor-carboxylationofosteocalcin
...-7)aregenerallyobservedinhumanplasma;however,dataarelimitedontheircirculatingconcentrationsandtheirassociationswithbonemetabolismorwith-carboxylationoftheosteocalcinmolecule.Objectives:TheobjectivesweretomeasurethecirculatingconcentrationsofK1,MK-4,andMK-7inwomenandtoascertainwhethereachformofvitami...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2006年83卷第2期睡眠剝奪對大鼠胃排空及胃腸激素的影響
...鼠胃黏膜中胃泌素含量分別爲(268±118),(306±151),(405±164)ng/L分別與單獨籠養組、對照組及睡眠剝奪1d組比較均明顯升高(t=2.104-4.787,P<0.05-0.01)。胃動素含量分別爲(51±32),(43±28),(36±20)ng/L,分別與單獨籠養組、對照組及睡眠...
行業資訊;臨牀快報;消化系統胰腺癌患者血清可溶性Apo-1/Fas水平變化及其臨牀意義
...清sApo-1/Fas水平。結果胰腺癌患者血清sApo-1/Fas爲(8.37±1.49)ng/L,明顯高於正常對照組(P<0.01)。胰腺癌患者血清sApo-1/Fas水平與臨牀分期有關,Ⅳ期胰腺癌血清sApo-1/Fas水平明顯高於其他各期(P<0.01),Ⅲ期明顯高於Ⅱ期(P<0.01);與胰...
行業資訊;臨牀快報;腫瘤相關酵素誘導抗癲癇藥物與男性維他命D降低有關
...析。 服用酵素誘導AEDs的病患平均25-OH-D3值是19.2ng/mL,服用非種酵素誘導AEDs者是23.8ng/mL(P=.005);服用酵素誘導AEDs病患之血中鈣濃度是8.83mg/dL,服用非種酵素誘導AEDs者是9.16mg/dL(P=.00009);服用酵素誘導AEDs病患之原態副甲狀...
行業資訊;臨牀快報;神經科SelectiveupregulationoftheADP-ribosylcyclasesCD38andCD157byTNFbutnotbyRANK-Lrevealsdifferencesindownstreamsignaling
...ofthesameadaptormolecules.However,despitethesesimilarities,nodefinedsignalingschematichasemergedtoshowhoweachcytokinefavorsparticularpathways.Inthisreport,weinvestigatewhetherTNFandRANK-LdifferentiallyregulateADP-ribosylcyclases-enzymesthatareuniqueinbeingcrucialforimmunologicalfunctionyetdetrimenta...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第9期IL-1receptor–associatedkinaseMisacentralregulatorofosteoclastdifferentiationandactivation
...omthefusionofmacrophagesandtheyplayacentralroleinbonedevelopmentandremodelingviatheresorptionofbone.Therefore,osteoclastsareimportantmediatorsofbonelossthatleads,forexample,toosteoporosis.Interleukin(IL)-1receptor(IL-1R)–associatedkinaseM(IRAK-M)isonlyexpressedincellsofthemyeloidlineageanditinhibi...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第7期EnhancedExpressionofKeratinocyteGrowthFactorandItsReceptorCorrelateswithVenousInvasioninPancreaticCancer
...VEGF-Aexpressioninthecells.KGFRandKGFmayacttopromotevenousinvasionandtumorangiogenesisinPDAC,raisingthepossibilitythattheymayserveasnoveltherapeutictargetsinanti-angiogenicstrategiesinPDAC.--------------------------------------------------------------------------------Pancreaticductaladenocarcinoma(...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第6期ApigeninInhibitsImmunostimulatoryFunctionofDendriticCells:ImplicationofImmunotherapeuticAdjuvant
...asbeenshowntopossessanti-inflammatory,anticarcinogenic,andfreeradical-scavengingproperties.However,theinfluenceofapigeninontheimmunostimulatoryeffectsandmaturationofdendriticcells(DC)remains,forthemostpart,unknown.Inthisstudy,wehaveattemptedtoascertainwhetherapigenininfluencestheexpressionofsurfacem...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第9期中晚期前列腺癌內分泌治療臨牀分析
...%患者臨牀症狀得到改善,血清PSA下降[治療前(107.37±187.67)ng/mL與治療後3月(32.25±123.52)ng/mL,t=3.57,P<0.01;治療前與治療後6月(37.49±172.00)ng/mL,t=3.34,P0.05]。結論內分泌治療是前列腺癌治療的重要手段,可明顯控制疾病進展,改善尿路梗...
醫源資料庫;在線期刊;現代泌尿外科雜誌;2007年第11卷第5期